Nicola J. Brown
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View article: The CDK4/6 Inhibitor Palbociclib Inhibits Estrogen-Positive and Triple Negative Breast Cancer Bone Metastasis In Vivo
The CDK4/6 Inhibitor Palbociclib Inhibits Estrogen-Positive and Triple Negative Breast Cancer Bone Metastasis In Vivo Open
CDK 4/6 inhibitors have demonstrated significant improved survival for patients with estrogen receptor (ER) positive breast cancer (BC). However, the ability of these promising agents to inhibit bone metastasis from either ER+ve or triple …
View article: Supplementary Figure 1 from Use of Macrophages to Target Therapeutic Adenovirus to Human Prostate Tumors
Supplementary Figure 1 from Use of Macrophages to Target Therapeutic Adenovirus to Human Prostate Tumors Open
Supplementary Figure 1 from Use of Macrophages to Target Therapeutic Adenovirus to Human Prostate Tumors
View article: Supplementary Figure 2 from Use of Macrophages to Target Therapeutic Adenovirus to Human Prostate Tumors
Supplementary Figure 2 from Use of Macrophages to Target Therapeutic Adenovirus to Human Prostate Tumors Open
Supplementary Figure 2 from Use of Macrophages to Target Therapeutic Adenovirus to Human Prostate Tumors
View article: Data from Use of Macrophages to Target Therapeutic Adenovirus to Human Prostate Tumors
Data from Use of Macrophages to Target Therapeutic Adenovirus to Human Prostate Tumors Open
New therapies are required to target hypoxic areas of tumors as these sites are highly resistant to conventional cancer therapies. Monocytes continuously extravasate from the bloodstream into tumors where they differentiate into macrophage…
View article: Supplementary Figure 2 from Use of Macrophages to Target Therapeutic Adenovirus to Human Prostate Tumors
Supplementary Figure 2 from Use of Macrophages to Target Therapeutic Adenovirus to Human Prostate Tumors Open
Supplementary Figure 2 from Use of Macrophages to Target Therapeutic Adenovirus to Human Prostate Tumors
View article: Supplementary Figure 4 from Use of Macrophages to Target Therapeutic Adenovirus to Human Prostate Tumors
Supplementary Figure 4 from Use of Macrophages to Target Therapeutic Adenovirus to Human Prostate Tumors Open
Supplementary Figure 4 from Use of Macrophages to Target Therapeutic Adenovirus to Human Prostate Tumors
View article: Supplementary Figure 3 from Use of Macrophages to Target Therapeutic Adenovirus to Human Prostate Tumors
Supplementary Figure 3 from Use of Macrophages to Target Therapeutic Adenovirus to Human Prostate Tumors Open
Supplementary Figure 3 from Use of Macrophages to Target Therapeutic Adenovirus to Human Prostate Tumors
View article: Supplementary Figure 4 from Use of Macrophages to Target Therapeutic Adenovirus to Human Prostate Tumors
Supplementary Figure 4 from Use of Macrophages to Target Therapeutic Adenovirus to Human Prostate Tumors Open
Supplementary Figure 4 from Use of Macrophages to Target Therapeutic Adenovirus to Human Prostate Tumors
View article: Supplementary Figure 5 from Use of Macrophages to Target Therapeutic Adenovirus to Human Prostate Tumors
Supplementary Figure 5 from Use of Macrophages to Target Therapeutic Adenovirus to Human Prostate Tumors Open
Supplementary Figure 5 from Use of Macrophages to Target Therapeutic Adenovirus to Human Prostate Tumors
View article: Data from Use of Macrophages to Target Therapeutic Adenovirus to Human Prostate Tumors
Data from Use of Macrophages to Target Therapeutic Adenovirus to Human Prostate Tumors Open
New therapies are required to target hypoxic areas of tumors as these sites are highly resistant to conventional cancer therapies. Monocytes continuously extravasate from the bloodstream into tumors where they differentiate into macrophage…
View article: Supplementary Figure 5 from Use of Macrophages to Target Therapeutic Adenovirus to Human Prostate Tumors
Supplementary Figure 5 from Use of Macrophages to Target Therapeutic Adenovirus to Human Prostate Tumors Open
Supplementary Figure 5 from Use of Macrophages to Target Therapeutic Adenovirus to Human Prostate Tumors
View article: Supplementary Figure 3 from Use of Macrophages to Target Therapeutic Adenovirus to Human Prostate Tumors
Supplementary Figure 3 from Use of Macrophages to Target Therapeutic Adenovirus to Human Prostate Tumors Open
Supplementary Figure 3 from Use of Macrophages to Target Therapeutic Adenovirus to Human Prostate Tumors
View article: Supplementary Figure 1 from Use of Macrophages to Target Therapeutic Adenovirus to Human Prostate Tumors
Supplementary Figure 1 from Use of Macrophages to Target Therapeutic Adenovirus to Human Prostate Tumors Open
Supplementary Figure 1 from Use of Macrophages to Target Therapeutic Adenovirus to Human Prostate Tumors
View article: Quality of Life in Post‐Surgical Hypoparathyroidism (PoSH) in Thyroid and Parathyroid Surgery
Quality of Life in Post‐Surgical Hypoparathyroidism (PoSH) in Thyroid and Parathyroid Surgery Open
Background Post‐surgical hypoparathyroidism (PoSH) is often long term, with significant associated morbidity and ongoing treatment. A recent systematic review found impaired quality of life (QoL) in patients with PoSH, despite stable treat…
View article: Changes in dynamics of tumor/endothelial cell adhesive interactions depending on endothelial cell growth state and elastic properties
Changes in dynamics of tumor/endothelial cell adhesive interactions depending on endothelial cell growth state and elastic properties Open
Cancer cell adhesion to the endothelium is a crucial process in hematogenous metastasis, but how the integrity of the endothelial barrier and endothelial cell (EC) mechanical properties influence the adhesion between metastatic cancer cell…
View article: Effects of Telephone-Based Peer Support in Patients With Type 2 Diabetes Mellitus Receiving Integrated Care: A Randomized Clinical Trial
Effects of Telephone-Based Peer Support in Patients With Type 2 Diabetes Mellitus Receiving Integrated Care: A Randomized Clinical Trial Open
IMPORTANCE In type 2 diabetes mellitus (T2DM), team management using protocols with regular feedback improves clinical outcomes, although suboptimal self-management and psychological distress remain significant challenges. OBJECTIVE To inv…
View article: Atomic force microscopy reveals the mechanical properties of breast cancer bone metastases
Atomic force microscopy reveals the mechanical properties of breast cancer bone metastases Open
Mechanically dependent processes are essential in cancer metastases. However, reliable mechanical characterisation of metastatic cancer remains challenging whilst maintaining the tissue complexity and an intact sample. Using atomic force m…
View article: Antecedents of creativity: testing a new psychometric measure of creative motivation
Antecedents of creativity: testing a new psychometric measure of creative motivation Open
This study offers evidence for the validity of a new psychometric measure in assessing an individual’s creative motivation and helping to predict their creative performance. The aim of this study was to examine the relationship of this new…
View article: Antecedents of creativity: testing a new psychometric measure of creative motivation
Antecedents of creativity: testing a new psychometric measure of creative motivation Open
This study offers evidence for the validity of a new psychometric measure in assessing an individual’s creative motivation and helping to predict their creative performance. The aim of this study was to examine the relationship of this new…
View article: Osteoblast-Derived Paracrine and Juxtacrine Signals Protect Disseminated Breast Cancer Cells from Stress
Osteoblast-Derived Paracrine and Juxtacrine Signals Protect Disseminated Breast Cancer Cells from Stress Open
Metastatic breast cancer in bone is incurable and there is an urgent need to develop new therapeutic approaches to improve survival. Key to this is understanding the mechanisms governing cancer cell survival and growth in bone, which invol…
View article: Atomic force microscopy reveals the mechanical properties of breast cancer bone metastases
Atomic force microscopy reveals the mechanical properties of breast cancer bone metastases Open
The metastatic tumour growing in bone is mechanically distinct from both its surrounding environment and in vitro models.
View article: The impact of signposting and group support pathways on a community-based physical activity intervention grounded in motivational interviewing
The impact of signposting and group support pathways on a community-based physical activity intervention grounded in motivational interviewing Open
Background: Brief advice is recommended to increase physical activity (PA) within primary care. This study assessed change in PA levels and mental wellbeing after a motivational interviewing (MI) community-based PA intervention and the imp…
View article: The impact of participant pathways on the effectiveness of a community-based physical activity intervention grounded in motivational interviewing
The impact of participant pathways on the effectiveness of a community-based physical activity intervention grounded in motivational interviewing Open
Background: Brief advice is recommended to increase physical activity (PA) within primary care. This study assessed change in PA levels and mental wellbeing after a motivational interviewing (MI) community-based PA intervention and the imp…
View article: Bioengineering bacterial outer membrane vesicles as delivery system for RNA therapeutics targeted to lung epithelial cytosols
Bioengineering bacterial outer membrane vesicles as delivery system for RNA therapeutics targeted to lung epithelial cytosols Open
Intact epithelia lining the airways and alveoli in the lung are essential to maintain lung function. Structural or functional damage of epithelial cells leads in severe diseases, including COPD/emphysema, ibrosis or ALI/ARDS. This central …
View article: Mechanical Heterogeneity in the Bone Microenvironment as Characterised by Atomic Force Microscopy
Mechanical Heterogeneity in the Bone Microenvironment as Characterised by Atomic Force Microscopy Open
Bones are structurally heterogeneous organs with diverse functions that undergo mechanical stimuli across multiple length scales. Mechanical characterisation of the bone microenvironment is important for understanding how bones function in…