Jane C. Stinchcombe
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View article: Ectocytosis renders T cell receptor signaling self-limiting at the immune synapse
Ectocytosis renders T cell receptor signaling self-limiting at the immune synapse Open
Cytotoxic T lymphocytes (CTLs) kill virus-infected and cancer cells through T cell receptor (TCR) recognition. How CTLs terminate signaling and disengage to allow serial killing has remained a mystery. TCR activation triggers membrane spec…
View article: Deletion of SNX9 alleviates CD8 T cell exhaustion for effective cellular cancer immunotherapy
Deletion of SNX9 alleviates CD8 T cell exhaustion for effective cellular cancer immunotherapy Open
Tumor-specific T cells are frequently exhausted by chronic antigenic stimulation. We here report on a human antigen-specific ex vivo model to explore new therapeutic options for T cell immunotherapies. T cells generated with this model res…
View article: Super‐killer CTLs are generated by single gene deletion of Bach2
Super‐killer CTLs are generated by single gene deletion of Bach2 Open
Bach2 codes for a transcriptional regulator exerting major influences on T cell‐mediated immune regulation. Effector CTLs derived from in vitro activation of murine CD8 + T cells showed increased proliferative and cytolytic capacity in the…
View article: Mitochondrial translation is required for sustained killing by cytotoxic T cells
Mitochondrial translation is required for sustained killing by cytotoxic T cells Open
Mitochondria drive CTLs’ killer instinct Cytotoxic T lymphocytes (CTLs) can terminate both virally infected cells and cancer cells by secreting cytolytic proteins such as perforin and granzyme B. CTLs are particularly effective because the…
View article: Teasing out function from morphology: Similarities between primary cilia and immune synapses
Teasing out function from morphology: Similarities between primary cilia and immune synapses Open
Immune synapses are formed between immune cells to facilitate communication and coordinate the immune response. The reorganization of receptors involved in recognition and signaling creates a transient area of plasma membrane specialized i…
View article: Loss of ARPC1B impairs cytotoxic T lymphocyte maintenance and cytolytic activity.
Loss of ARPC1B impairs cytotoxic T lymphocyte maintenance and cytolytic activity. Open
CD8 cytotoxic T lymphocytes (CTLs) rely on rapid reorganization of the branched F-actin network to drive the polarized secretion of lytic granules, initiating target cell death during the adaptive immune response. Branched F-actin is gener…
View article: Loss of ARPC1B impairs cytotoxic T lymphocyte maintenance and cytolytic activity
Loss of ARPC1B impairs cytotoxic T lymphocyte maintenance and cytolytic activity Open
CD8 cytotoxic T lymphocytes (CTLs) rely on rapid reorganization of the branched F-actin network to drive the polarized secretion of lytic granules, initiating target cell death during the adaptive immune response. Branched F-actin is gener…
View article: Inducible T Cell Kinase Regulates the Acquisition of Cytolytic Capacity and Degranulation in CD8+ CTLs
Inducible T Cell Kinase Regulates the Acquisition of Cytolytic Capacity and Degranulation in CD8+ CTLs Open
Patients with mutations in inducible T cell kinase (ITK) are susceptible to viral infections, particularly EBV, suggesting that these patients have defective function of CD8+ CTLs. In this study, we evaluated the effects of ITK deficiency …
View article: The cytotoxic T lymphocyte immune synapse at a glance
The cytotoxic T lymphocyte immune synapse at a glance Open
The immune synapse provides an important structure for communication with immune cells. Studies on immune synapses formed by cytotoxic T lymphocytes (CTLs) highlight the dynamic changes and specialised mechanisms required to facilitate foc…