Jane Clark
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View article: 50% body weight loading reduces stature increases and lumbar disc expansion from 4 h hyper‐buoyancy floatation versus 15 min sitting upright
50% body weight loading reduces stature increases and lumbar disc expansion from 4 h hyper‐buoyancy floatation versus 15 min sitting upright Open
Microgravity is associated with stature increases, back pain and post‐flight intervertebral disc (IVD) herniation. This study aims to determine whether 30 s seated 50% body weight (BW) axial loading is comparable to 15 min sitting upright …
View article: Bivalent RSVpreF Vaccine in Adults 18 to <60 Years Old With High-Risk Conditions
Bivalent RSVpreF Vaccine in Adults 18 to <60 Years Old With High-Risk Conditions Open
Background Older individuals and adults with certain chronic or immunocompromising health conditions are at increased risk of severe respiratory syncytial virus (RSV) disease. Methods In this phase 3 randomized trial of RSVpreF safety and …
View article: Correction: Ruchaya et al. Transplantation of Skeletal Muscle-Derived Sca-1+/PW1+/Pax7− Interstitial Cells (PICs) Improves Cardiac Function and Attenuates Remodeling in Mice Subjected to Myocardial Infarction. Cells 2022, 11, 4050
Correction: Ruchaya et al. Transplantation of Skeletal Muscle-Derived Sca-1+/PW1+/Pax7− Interstitial Cells (PICs) Improves Cardiac Function and Attenuates Remodeling in Mice Subjected to Myocardial Infarction. Cells 2022, 11, 4050 Open
In the original publication [...]
View article: Perfusion-Independent Tissue Hypoxia in Cardiac Hypertrophy in Mice Measured by<sup>64</sup>Cu-CTS PET Imaging
Perfusion-Independent Tissue Hypoxia in Cardiac Hypertrophy in Mice Measured by<sup>64</sup>Cu-CTS PET Imaging Open
Background Hypoxia is central to many cardiac pathologies, but clinically its presence can only be inferred by indirect biomarkers including hypoperfusion and energetic compromise. Imaging hypoxia directly could offer new opportunities for…
View article: Transient Receptor Potential Canonical 5 (TRPC5): Regulation of Heart Rate and Protection against Pathological Cardiac Hypertrophy
Transient Receptor Potential Canonical 5 (TRPC5): Regulation of Heart Rate and Protection against Pathological Cardiac Hypertrophy Open
TRPC5 is a non-selective cation channel that is expressed in cardiomyocytes, but there is a lack of knowledge of its (patho)physiological role in vivo. Here, we examine the role of TRPC5 on cardiac function under basal conditions and durin…
View article: Proposed treatment strategy for reactive hypoglycaemia
Proposed treatment strategy for reactive hypoglycaemia Open
Background/aim Managing reactive hypoglycaemia (RH) poses challenges due to limited and often ineffective treatment options. We report a case series and draw on this to propose a stepwise treatment approach consisting of lifestyle modifica…
View article: Cyclin D-CDK4 Disulfide Bond Attenuates Pulmonary Vascular Cell Proliferation
Cyclin D-CDK4 Disulfide Bond Attenuates Pulmonary Vascular Cell Proliferation Open
BACKGROUND: Pulmonary hypertension (PH) is a chronic vascular disease characterized, among other abnormalities, by hyperproliferative smooth muscle cells and a perturbed cellular redox and metabolic balance. Oxidants induce cell cycle arre…
View article: Transplantation of Skeletal Muscle-Derived Sca-1+/PW1+/Pax7− Interstitial Cells (PICs) Improves Cardiac Function and Attenuates Remodeling in Mice Subjected to Myocardial Infarction
Transplantation of Skeletal Muscle-Derived Sca-1+/PW1+/Pax7− Interstitial Cells (PICs) Improves Cardiac Function and Attenuates Remodeling in Mice Subjected to Myocardial Infarction Open
We have previously shown that skeletal muscle-derived Sca-1+/PW1+/Pax7− interstitial cells (PICs) are multi-potent and enhance endogenous repair and regeneration. Here, we investigated the regenerative potential of PICs following intramyoc…
View article: Reported outcome measures for colorectal cancer patients during the COVID‐19 pandemic
Reported outcome measures for colorectal cancer patients during the COVID‐19 pandemic Open
None of the authors have any conflicting interest to declare.
View article: p38γ MAPK contributes to left ventricular remodeling after pathologic stress and disinhibits calpain through phosphorylation of calpastatin
p38γ MAPK contributes to left ventricular remodeling after pathologic stress and disinhibits calpain through phosphorylation of calpastatin Open
Despite the high and preferential expression of p38γ MAPK in the myocardium, little is known about its function in the heart. The aim of the current study was to elucidate the physiologic and biochemical roles of p38γ in the heart. Express…
View article: The POU4F2/Brn-3b transcription factor is required for the hypertrophic response to angiotensin II in the heart
The POU4F2/Brn-3b transcription factor is required for the hypertrophic response to angiotensin II in the heart Open
Adult hearts respond to increased workload such as prolonged stress or injury, by undergoing hypertrophic growth. During this process, the early adaptive responses are important for maintaining cardiac output whereas at later stages, patho…
View article: Aged‐senescent cells contribute to impaired heart regeneration
Aged‐senescent cells contribute to impaired heart regeneration Open
Aging leads to increased cellular senescence and is associated with decreased potency of tissue‐specific stem/progenitor cells. Here, we have done an extensive analysis of cardiac progenitor cells (CPCs) isolated from human subjects with c…
View article: Dynamic heart rate response to multi‐day unsupported ultra‐endurance cycle racing: a case report
Dynamic heart rate response to multi‐day unsupported ultra‐endurance cycle racing: a case report Open
New Findings What is the main observation in this case? Ultra‐endurance cycle racing is known to lead to suppressed heart rates as a product of time spent racing. This case report identifies a racer who experienced this phenomenon initiall…
View article: The TAB1-p38α complex aggravates myocardial injury and can be targeted by small molecules
The TAB1-p38α complex aggravates myocardial injury and can be targeted by small molecules Open
Inhibiting MAPK14 (p38α) diminishes cardiac damage in myocardial ischemia. During myocardial ischemia, p38α interacts with TAB1, a scaffold protein, which promotes p38α autoactivation; active p38α (pp38α) then transphosphorylates TAB1. Pre…
View article: Aged-senescent cells contribute to impaired heart regeneration
Aged-senescent cells contribute to impaired heart regeneration Open
Aging leads to increased cellular senescence and is associated with decreased potency of tissue-specific stem/progenitor cells. Here we have done an extensive analysis of cardiac progenitor cells (CPCs) isolated from human subjects with ca…
View article: Pravastatin therapy during preeclampsia prevents long-term adverse health effects in mice
Pravastatin therapy during preeclampsia prevents long-term adverse health effects in mice Open
Preeclampsia (PE), associates with long-term increased risk for cardiovascular disease in women, suggesting that PE is not an isolated disease of pregnancy. It is not known if increased risk for long-term diseases is due to PE-specific fac…
View article: Beer, hyponatraemia and cardiac conduction defects
Beer, hyponatraemia and cardiac conduction defects Open
The authors report a case of a 68-year-old man who was diagnosed with an irreversible second-degree atrioventricular (AV) Mobitz II 2:1 block temporally associated with profound hyponatraemia. The cause of the hyponatraemia was beer potoma…
View article: Cardioprotection by an anti-MASP-2 antibody in a murine model of myocardial infarction
Cardioprotection by an anti-MASP-2 antibody in a murine model of myocardial infarction Open
Background Myocardial ischaemia–reperfusion injury is a major cause of mortality and morbidity in the developed world. Many approaches have been investigated to counteract the pathological consequences associated with acute myocardial infa…
View article: Delayed diagnosis of severe secondary hypothyroidism in a patient presenting with mixed hyperlipidaemia and metabolic myositis
Delayed diagnosis of severe secondary hypothyroidism in a patient presenting with mixed hyperlipidaemia and metabolic myositis Open
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
View article: Loss of Protein Kinase Novel 1 (PKN1) is associated with mild systolic and diastolic contractile dysfunction, increased phospholamban Thr17 phosphorylation, and exacerbated ischaemia-reperfusion injury
Loss of Protein Kinase Novel 1 (PKN1) is associated with mild systolic and diastolic contractile dysfunction, increased phospholamban Thr17 phosphorylation, and exacerbated ischaemia-reperfusion injury Open
Aims PKN1 is a stress-responsive protein kinase acting downstream of small GTP-binding proteins of the Rho/Rac family. The aim was to determine its role in endogenous cardioprotection. Methods and results Hearts from PKN1 knockout (KO) or …