Jane E. Norman
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View article: Antenatal Corticosteroids and Infectious Diseases Throughout Childhood
Antenatal Corticosteroids and Infectious Diseases Throughout Childhood Open
Importance International guidelines recommend the use of antenatal corticosteroids (ACS) in pregnancies at risk of imminent preterm birth before 34 weeks’ gestation. However, whether ACS leads to long-term risk of infection from childhood …
View article: Hidden costs of unaffordable housing: Exploring the multidimensional and intersecting health effects on Black Americans
Hidden costs of unaffordable housing: Exploring the multidimensional and intersecting health effects on Black Americans Open
Background: Housing, a key health determinant, is increasingly unaffordable. Black/African-American communities are disproportionately affected due to a long, documented history of structural racism in housing. To date, much unaffordable h…
View article: ABO blood group antigens influence host–microbe interactions and risk of early spontaneous preterm birth
ABO blood group antigens influence host–microbe interactions and risk of early spontaneous preterm birth Open
The mechanisms by which vaginal microbiota shape spontaneous preterm birth (sPTB) risk remain poorly defined. Using electronic clinical records data from 74,913 maternities in conjunction with metaxanomic ( n = 596) and immune profiling ( …
View article: Integration of Quality into Operations Planning
Integration of Quality into Operations Planning Open
View article: <scp>CD19</scp> chimeric antigen receptor T‐cell efficacy and toxicity in adults with Richter's transformation and response to bridging therapy
<span>CD19</span> chimeric antigen receptor T‐cell efficacy and toxicity in adults with Richter's transformation and response to bridging therapy Open
View article: 326 | GLOFITAMAB AND EPCORITAMAB FOR LARGE B CELL LYMPHOMA IN 319 REAL WORLD PATIENTS: A RETROSPECTIVE UK ANALYSIS OF EFFICACY, TOLERABILITY AND PRACTICAL IMPLICATIONS
326 | GLOFITAMAB AND EPCORITAMAB FOR LARGE B CELL LYMPHOMA IN 319 REAL WORLD PATIENTS: A RETROSPECTIVE UK ANALYSIS OF EFFICACY, TOLERABILITY AND PRACTICAL IMPLICATIONS Open
View article: 782 | GAME SET AND MATCH FOR CAR‐T IN DLBCL? WHY TREATMENT BIAS AGAINST BISPECIFIC ANTIBODIES MAY MAKE MATCHED REAL‐WORLD COMPARISONS UNINTERPRETABLE
782 | GAME SET AND MATCH FOR CAR‐T IN DLBCL? WHY TREATMENT BIAS AGAINST BISPECIFIC ANTIBODIES MAY MAKE MATCHED REAL‐WORLD COMPARISONS UNINTERPRETABLE Open
View article: 459 | OUTCOMES OF SECOND‐LINE AXICABTAGENE CILOLEUCEL FOR LARGE B‐CELL LYMPHOMA IN THE UK
459 | OUTCOMES OF SECOND‐LINE AXICABTAGENE CILOLEUCEL FOR LARGE B‐CELL LYMPHOMA IN THE UK Open
View article: 15 | EARLY PET RESPONSE PREDICTS RISK OF RELAPSE AFTER 2L AXI‐CEL IN LARGE B‐CELL LYMPHOMA
15 | EARLY PET RESPONSE PREDICTS RISK OF RELAPSE AFTER 2L AXI‐CEL IN LARGE B‐CELL LYMPHOMA Open
View article: Treatment outcomes in patients with large B‐cell lymphoma after progression to chimeric antigen receptor T‐cell therapy
Treatment outcomes in patients with large B‐cell lymphoma after progression to chimeric antigen receptor T‐cell therapy Open
Over 60% of relapsed/refractory (R/R) large B‐cell lymphoma (LBCL) patients who receive chimeric antigen receptor (CAR) T cells will experience disease progression. There is no standard next line of therapy and information in this setting …
View article: Outcomes after chimeric antigen receptor T-cell therapy across large B-cell lymphoma subtypes
Outcomes after chimeric antigen receptor T-cell therapy across large B-cell lymphoma subtypes Open
Not available.
View article: Ibrutinib as first-line therapy for mantle cell lymphoma: a multicenter, real-world UK study
Ibrutinib as first-line therapy for mantle cell lymphoma: a multicenter, real-world UK study Open
During the COVID-19 pandemic, ibrutinib with or without rituximab was approved in England for initial treatment of mantle cell lymphoma (MCL) instead of immunochemotherapy. Because limited data are available in this setting, we conducted a…
View article: P1413: DOES TOCILIZUMAB INCREASE THE RISK OF INFECTIONS IN PATIENTS UNDERGOING CAR-T THERAPY?
P1413: DOES TOCILIZUMAB INCREASE THE RISK OF INFECTIONS IN PATIENTS UNDERGOING CAR-T THERAPY? Open
Topic: 25. Gene therapy, cellular immunotherapy and vaccination - Clinical Background: Chimeric antigen receptor T-cell (CAR-T) therapy has emerged as a promising treatment option for patients with relapsed/refractory large B-cell lymphoma…
View article: PROMPT: Prospective Meta-analysis for Pessary Trials Study Protocol
PROMPT: Prospective Meta-analysis for Pessary Trials Study Protocol Open
Objective Preterm birth, defined as birth before 37 weeks of gestation, is a leading cause of perinatal and infant mortality throughout the world. Preterm birth is also associated with long-term neurological disabilities and other signific…
View article: RADIOTHERAPY BRIDGING IN LARGE B‐CELL LYMPHOMA PATIENTS RECEIVING CD19 CAR‐T – THE UK EXPERIENCE
RADIOTHERAPY BRIDGING IN LARGE B‐CELL LYMPHOMA PATIENTS RECEIVING CD19 CAR‐T – THE UK EXPERIENCE Open
Background: Radiotherapy (RT) has potential synergistic effects with CAR T but is not widely used as bridging therapy for lymphoma patients due to logistical challenges, uncertainty about patient selection and lack of standardised protocol…
View article: <scp>CAR</scp> T in patients with large B‐cell lymphoma not fit for autologous transplant
<span>CAR</span> T in patients with large B‐cell lymphoma not fit for autologous transplant Open
Summary Large B‐cell lymphoma (LBCL) patients with comorbidities and/or advanced age are increasingly considered for treatment with CD19 CAR T, but data on the clinical benefit of CAR T in the less fit patient population are still limited.…
View article: The need for appropriate language in the debate on medicalisation of pregnancy
The need for appropriate language in the debate on medicalisation of pregnancy Open
View article: Implementation of a novel ultrasound training programme for midwives in Malawi: A mixed methods evaluation using the RE-AIM framework
Implementation of a novel ultrasound training programme for midwives in Malawi: A mixed methods evaluation using the RE-AIM framework Open
Introduction Despite recommendation that all women receive an ultrasound in pregnancy prior to 24 weeks', this remains unavailable to many women in low-income countries where trained practitioners are scarce. Although many programmes have …
View article: Protocol for a multi-site randomised controlled feasibility study investigating intermittently scanned blood glucose monitoring for gestational diabetes- the RECOGNISE study
Protocol for a multi-site randomised controlled feasibility study investigating intermittently scanned blood glucose monitoring for gestational diabetes- the RECOGNISE study Open
Abstract Background: Incidence of gestational diabetes mellitus (GDM) is increasing and is associated with adverse perinatal outcomes including macrosomia, pre-eclampsia and pre-term delivery. Optimum glycaemic control is associated with r…
View article: Monofilament suture versus braided suture thread to improve pregnancy outcomes after vaginal cervical cerclage (C-STICH): a pragmatic randomised, controlled, phase 3, superiority trial
Monofilament suture versus braided suture thread to improve pregnancy outcomes after vaginal cervical cerclage (C-STICH): a pragmatic randomised, controlled, phase 3, superiority trial Open
National Institute of Health Research Health Technology Assessment Programme.
View article: P1141: IBRUTINIB AND RITUXIMAB AS FIRST LINE THERAPY FOR MANTLE CELL LYMPHOMA: A MULTICENTRE, REAL-WORLD UK STUDY
P1141: IBRUTINIB AND RITUXIMAB AS FIRST LINE THERAPY FOR MANTLE CELL LYMPHOMA: A MULTICENTRE, REAL-WORLD UK STUDY Open
Background: Ibrutinib (IBR) is an oral covalent Bruton tyrosine kinase inhibitor (BTKi), licensed for treatment of relapsed or refractory mantle cell lymphoma (MCL). Under NHS interim Covid-19 agreements in England, IBR with or without rit…
View article: After the Ockenden review: a chance to reset maternal and perinatal care in the UK?
After the Ockenden review: a chance to reset maternal and perinatal care in the UK? Open
View article: Training in Ultrasound to Determine Gestational Age (TUDA): Evaluation of a Novel Education Package to Teach Ultrasound-Naive Midwives Basic Obstetric Ultrasound in Malawi
Training in Ultrasound to Determine Gestational Age (TUDA): Evaluation of a Novel Education Package to Teach Ultrasound-Naive Midwives Basic Obstetric Ultrasound in Malawi Open
Introduction Although ultrasound to determine gestational age is fundamental to the optimum management of pregnancy and is recommended for all women by the World Health Organisation, it remains unavailable to many women in low-income count…
View article: Awareness of fetal movements and care package to reduce fetal mortality (AFFIRM): a trial-based and model-based cost-effectiveness analysis from a stepped wedge, cluster-randomised trial
Awareness of fetal movements and care package to reduce fetal mortality (AFFIRM): a trial-based and model-based cost-effectiveness analysis from a stepped wedge, cluster-randomised trial Open
View article: Training in Ultrasound to Determine Gestational Age in Low- and Middle- Income Countries: A Systematic Review
Training in Ultrasound to Determine Gestational Age in Low- and Middle- Income Countries: A Systematic Review Open
Introduction Establishing an accurate gestational age is essential for the optimum management of pregnancy, delivery and neonatal care, with improved estimates of gestational age considered a public health priority by the World Health Orga…
View article: My Baby's Movements: A Stepped-Wedge Cluster-Randomised Controlled Trial of a Fetal Movement Awareness Intervention to Reduce Stillbirths
My Baby's Movements: A Stepped-Wedge Cluster-Randomised Controlled Trial of a Fetal Movement Awareness Intervention to Reduce Stillbirths Open
(Abstracted from BJOG 2022;129:29–41) Decreased fetal movement (DFM) can indicate that a pregnancy is at risk for stillbirth. Maternal awareness and monitoring of fetal movement have been considered to be a simple, low-cost stillbirth prev…
View article: Microbial-driven preterm labour involves crosstalk between the innate and adaptive immune response
Microbial-driven preterm labour involves crosstalk between the innate and adaptive immune response Open
View article: The Arabin Pessary to Prevent Preterm Birth in Women With a Twin Pregnancy and a Short Cervix: The STOPPIT 2 RCT
The Arabin Pessary to Prevent Preterm Birth in Women With a Twin Pregnancy and a Short Cervix: The STOPPIT 2 RCT Open
(Abstracted from Health Technol Assess 2021;25:1–66) In England and Wales, approximately 16 of every 1000 women have a multiple gestation. Multiple pregnancies are associated with higher rates of stillbirth and neonatal and infant mortalit…
View article: Interventions to reduce preterm birth and stillbirth, and improve outcomes for babies born preterm in low- and middle-income countries: A systematic review
Interventions to reduce preterm birth and stillbirth, and improve outcomes for babies born preterm in low- and middle-income countries: A systematic review Open
Evidence supports the implementation of several low-cost interventions with the potential to deliver reductions in preterm birth and stillbirth and improve outcomes for preterm babies in LMICs. These, however, must be complemented by overa…
View article: Direct on-swab metabolic profiling of vaginal microbiome host interactions during pregnancy and preterm birth
Direct on-swab metabolic profiling of vaginal microbiome host interactions during pregnancy and preterm birth Open