Jane E. Parker
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View article: The Arabidopsis neutral amino acid transporter UmamiT20 confers <i>Botrytis cinerea</i> susceptibility
The Arabidopsis neutral amino acid transporter UmamiT20 confers <i>Botrytis cinerea</i> susceptibility Open
Plant pathogens rely on host-derived nutrients for proliferation, yet the mechanisms by which hosts supply these nutrients remain incompletely understood. Here, we show that infection of Arabidopsis thaliana by the necrotrophic fungus Botr…
View article: GH25 lysozyme mediates tripartite interkingdom interactions and microbial competition on the plant leaf surface
GH25 lysozyme mediates tripartite interkingdom interactions and microbial competition on the plant leaf surface Open
Microbial communities inhabiting plants have emerged as crucial factors in regulating plant health and defense against disease-causing pathogens. The yeast Moesziomyces bullatus ex. Albugo (MbA) on Arabidopsis produces a glycoside hydrolas…
View article: Coordinated actions of NLR-assembled and glutamate receptor–like calcium channels in plant effector-triggered immunity
Coordinated actions of NLR-assembled and glutamate receptor–like calcium channels in plant effector-triggered immunity Open
The plant immune system utilizes nucleotide-binding/leucine-rich repeat (NLR) proteins to detect pathogen virulence factors (effectors) inside host cells and transduce recognition to rapid defense. In dicotyledenous plants, pathogen activa…
View article: Cooperation between a root fungal endophyte and host‐derived coumarin scopoletin mediates <i>Arabidopsis</i> iron nutrition
Cooperation between a root fungal endophyte and host‐derived coumarin scopoletin mediates <i>Arabidopsis</i> iron nutrition Open
Summary Iron acquisition is a critical challenge for plants, especially in iron‐deficient soils. Recent research underscores the importance of root‐exuded coumarins in modulating the root microbiome community structure and facilitating iro…
View article: Cooperation between a root fungal endophyte and host-derived coumarin scopoletin mediates <i>Arabidopsis</i> iron nutrition
Cooperation between a root fungal endophyte and host-derived coumarin scopoletin mediates <i>Arabidopsis</i> iron nutrition Open
Summary Iron acquisition is a critical challenge for plants, especially in iron-deficient soils. Recent research underscores the importance of root-exuded coumarins in modulating the root microbiome community structure and facilitating iro…
View article: GH25 lysozyme mediates tripartite interkingdom interactions and microbial competition on the plant leaf surface
GH25 lysozyme mediates tripartite interkingdom interactions and microbial competition on the plant leaf surface Open
Microbial communities inhabiting plants have emerged as crucial factors in regulating plant health and defense against disease-causing pathogens. The basidiomycete yeast Moesziomyces bullatus ex. Albugo on Arabidopsis ( MbA) releases Glyco…
View article: Inflammatory profile of lower risk myelodysplastic syndromes
Inflammatory profile of lower risk myelodysplastic syndromes Open
Summary The precise link between inflammation and pathogenesis of myelodysplastic syndrome (MDS) is yet to be fully established. We developed a novel method to measure ASC/NLRP3 protein specks which are specific for the NLRP3 inflammasome …
View article: WITHDRAWN: Immune regulators<i>EDS1</i>and<i>PAD4</i>constrain<i>ADR1</i>-dependent disease resistance in rice
WITHDRAWN: Immune regulators<i>EDS1</i>and<i>PAD4</i>constrain<i>ADR1</i>-dependent disease resistance in rice Open
Withdrawal Statement The authors have withdrawn this manuscript owing to finding inconsistencies in genotyping of kitaake rice eds1 pad4 double mutant lines and to establishing that combined loss of EDS1 and PAD4 does not underlie the stun…
View article: Bacillus cereus NJ01 induces SA- and ABA-mediated immunity against bacterial pathogens through the EDS1-WRKY18 module
Bacillus cereus NJ01 induces SA- and ABA-mediated immunity against bacterial pathogens through the EDS1-WRKY18 module Open
Emerging evidence suggests a beneficial role of rhizobacteria in ameliorating plant disease resistance in an environment-friendly way. In this study, we characterize a rhizobacterium, Bacillus cereus NJ01, that enhances bacterial pathogen …
View article: Cytoplasmic calcium influx mediated by plant MLKLs confers TNL-triggered immunity
Cytoplasmic calcium influx mediated by plant MLKLs confers TNL-triggered immunity Open
The plant homolog of vertebrate necroptosis inducer mixed-lineage kinase domain-like (MLKL) contributes to downstream steps in Toll-interleukin-1 receptor domain NLR (TNL)-receptor-triggered immunity. Here, we show that Arabidopsis MLKL1 (…
View article: Substrate-induced condensation activates plant TIR domain proteins
Substrate-induced condensation activates plant TIR domain proteins Open
Plant nucleotide-binding leucine-rich repeat (NLR) immune receptors with an N-terminal Toll/interleukin-1 receptor (TIR) domain mediate recognition of strain-specific pathogen effectors, typically via their C-terminal ligand-sensing domain…
View article: Plant NLR immunity activation and execution: a biochemical perspective
Plant NLR immunity activation and execution: a biochemical perspective Open
Plants deploy cell-surface and intracellular receptors to detect pathogen attack and trigger innate immune responses. Inside host cells, families of nucleotide-binding/leucine-rich repeat (NLR) proteins serve as pathogen sensors or downstr…
View article: Venetoclax–based low intensity therapy in molecular failure of <i>NPM1</i>-mutated AML
Venetoclax–based low intensity therapy in molecular failure of <i>NPM1</i>-mutated AML Open
Molecular failure in NPM1-mutated acute myeloid leukemia (AML) inevitably progresses to frank relapse if untreated. Recently published small case series show that venetoclax combined with low-dose cytarabine or azacitidine can reduce or el…
View article: Arabidopsis PHYTOALEXIN DEFICIENT 4 promotes the maturation and nuclear accumulation of immune-related cysteine protease RD19
Arabidopsis PHYTOALEXIN DEFICIENT 4 promotes the maturation and nuclear accumulation of immune-related cysteine protease RD19 Open
Arabidopsis PHYTOALEXIN DEFICIENT 4 (PAD4) has an essential role in pathogen resistance as a heterodimer with ENHANCED DISEASE SUSCEPTIBILITY 1 (EDS1). Here we investigated an additional PAD4 role in which it associates with and promotes t…
View article: New Biochemical Principles for NLR Immunity in Plants
New Biochemical Principles for NLR Immunity in Plants Open
While working for the United States Department of Agriculture on the North Dakota Agricultural College campus in Fargo, North Dakota, in the 1940s and 1950s, Harold H. Flor formulated the genetic principles for coevolving plant host-pathog…
View article: Arabidopsis Topless‐related 1 mitigates physiological damage and growth penalties of induced immunity
Arabidopsis Topless‐related 1 mitigates physiological damage and growth penalties of induced immunity Open
Summary Transcriptional corepressors of the Topless (TPL) family regulate plant hormone and immunity signaling. The lack of a genome‐wide profile of their chromatin associations limits understanding of the TPL family roles in transcription…
View article: TIR-domain enzymatic activities at the heart of plant immunity
TIR-domain enzymatic activities at the heart of plant immunity Open
Toll/interleukin-1/resistance (TIR) domain proteins contribute to innate immunity in all cellular kingdoms. TIR modules are activated by self-association and in plants, mammals and bacteria, some TIRs have enzymatic functions that are cruc…
View article: Oligomerization of a plant helper NLR requires cell-surface and intracellular immune receptor activation
Oligomerization of a plant helper NLR requires cell-surface and intracellular immune receptor activation Open
Plant disease resistance involves both detection of microbial molecular patterns by cell-surface pattern recognition receptors and detection of pathogen effectors by intracellular NLR immune receptors. NLRs are classified as sensor NLRs, i…
View article: Effector XopQ-induced stromule formation in<i>Nicotiana benthamiana</i>depends on ETI signaling components ADR1 and NRG1
Effector XopQ-induced stromule formation in<i>Nicotiana benthamiana</i>depends on ETI signaling components ADR1 and NRG1 Open
In Nicotiana benthamiana, the expression of the Xanthomonas effector XANTHOMONAS OUTER PROTEIN Q (XopQ) triggers RECOGNITION OF XOPQ1 (ROQ1)-dependent effector-triggered immunity (ETI) responses accompanied by the accumulation of plastids …
View article: Variation in plant Toll/Interleukin-1 receptor domain protein dependence on <i>ENHANCED DISEASE SUSCEPTIBILITY 1</i>
Variation in plant Toll/Interleukin-1 receptor domain protein dependence on <i>ENHANCED DISEASE SUSCEPTIBILITY 1</i> Open
Toll/Interleukin-1 receptor (TIR) domains are integral to immune systems across all kingdoms. In plants, TIRs are present in nucleotide-binding leucine-rich repeat (NLR) immune receptors, NLR-like, and TIR-only proteins. Although TIR-NLR a…
View article: <scp>EDS1</scp> complexes are not required for <scp>PRR</scp> responses and execute <scp>TNL‐ETI</scp> from the nucleus in <i>Nicotiana benthamiana</i>
<span>EDS1</span> complexes are not required for <span>PRR</span> responses and execute <span>TNL‐ETI</span> from the nucleus in <i>Nicotiana benthamiana</i> Open
Summary Heterodimeric complexes incorporating the lipase‐like proteins EDS1 with PAD4 or SAG101 are central hubs in plant innate immunity. EDS1 functions encompass signal relay from TIR domain‐containing intracellular NLR‐type immune recep…
View article: Oligomerisation of a plant helper NLR requires cell-surface and intracellular immune receptor activation
Oligomerisation of a plant helper NLR requires cell-surface and intracellular immune receptor activation Open
Plant disease resistance involves both detection of microbial molecular patterns by cell-surface pattern recognition receptors and detection of pathogen effectors by intracellular NLR immune receptors. NLRs are classified as sensor NLRs, i…
View article: TIR-catalyzed ADP-ribosylation reactions produce signaling molecules for plant immunity
TIR-catalyzed ADP-ribosylation reactions produce signaling molecules for plant immunity Open
Plant pathogen-activated immune signaling by nucleotide-binding leucine-rich repeat (NLR) receptors with an N-terminal Toll/Interleukin-1 receptor (TIR) domain converges on Enhanced Disease Susceptibility 1 (EDS1) and its direct partners P…
View article: Identification and receptor mechanism of TIR-catalyzed small molecules in plant immunity
Identification and receptor mechanism of TIR-catalyzed small molecules in plant immunity Open
Plant nucleotide-binding leucine-rich-repeat receptors (NLRs) with an N-terminal toll/interleukin-1 receptor (TIR) domain sense pathogen effectors to enable TIR-encoded NADase activity for immune signaling. TIR-NLR (TNL) signaling requires…
View article: Cavity surface residues of <scp>PAD4</scp> and <scp>SAG101</scp> contribute to <scp>EDS1</scp> dimer signaling specificity in plant immunity
Cavity surface residues of <span>PAD4</span> and <span>SAG101</span> contribute to <span>EDS1</span> dimer signaling specificity in plant immunity Open
SUMMARY Arabidopsis pathogen effector‐triggered immunity (ETI) is controlled by a family of three lipase‐like proteins (EDS1, PAD4, and SAG101) and two subfamilies of HET‐S/LOB‐B (HeLo)‐domain “helper” nucleotide‐binding/leucine‐rich repea…
View article: Molecular innovations in plant TIR-based immunity signaling
Molecular innovations in plant TIR-based immunity signaling Open
A protein domain (Toll and Interleukin-1 receptor [TIR]-like) with homology to animal TIRs mediates immune signaling in prokaryotes and eukaryotes. Here, we present an overview of TIR evolution and the molecular versatility of TIR domains …
View article: A new biochemistry connecting pathogen detection to induced defense in plants
A new biochemistry connecting pathogen detection to induced defense in plants Open
Summary Plant cell surface and intracellular immune receptors recognizing pathogen attack utilize the same defense machineries to mobilize resistance. New genetic, protein structural and biochemical information on receptor activation and s…
View article: Differential requirement for the EDS1 catalytic triad in<i>A. thaliana</i>and<i>N. benthamiana</i>
Differential requirement for the EDS1 catalytic triad in<i>A. thaliana</i>and<i>N. benthamiana</i> Open
Summary Heterodimeric complexes incorporating the lipase-like proteins EDS1 with PAD4 or SAG101 are central hubs in plant innate immunity. EDS1 functions encompass signal relay from TIR domain-containing intracellular NLR-type immune recep…