Jane E. Preston
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View article: The Hydrocephalus Association Patient-Powered Interactive Engagement Registry (HAPPIER): Design and Initial Baseline Report
The Hydrocephalus Association Patient-Powered Interactive Engagement Registry (HAPPIER): Design and Initial Baseline Report Open
HAPPIER is a novel database that addresses gaps in data on non-clinical outcomes of hydrocephalus, which are critical to clinical care and understanding hydrocephalus. Patient perspectives and outcomes remain historically underrepresented.…
View article: The Hydrocephalus Association Patient-Powered Interactive Engagement Registry (HAPPIER): Design and Initial Baseline Report
The Hydrocephalus Association Patient-Powered Interactive Engagement Registry (HAPPIER): Design and Initial Baseline Report Open
Objective Hydrocephalus is a neurological condition characterized by an accumulation of cerebrospinal fluid with no cure and limited treatments. There is a significant gap in hydrocephalus research where patients lack opportunities to voic…
View article: CoQ10 Deficient Endothelial Cell Culture Model for the Investigation of CoQ10 Blood–Brain Barrier Transport
CoQ10 Deficient Endothelial Cell Culture Model for the Investigation of CoQ10 Blood–Brain Barrier Transport Open
Primary coenzyme Q10 (CoQ10) deficiency is unique among mitochondrial respiratory chain disorders in that it is potentially treatable if high-dose CoQ10 supplements are given in the early stages of the disease. While supplements improve pe…
View article: Cerebrospinal fluid dynamics modulation by diet and cytokines in rats
Cerebrospinal fluid dynamics modulation by diet and cytokines in rats Open
Background Idiopathic intracranial hypertension (IIH) is a neurological disorder characterised by raised cerebrospinal fluid (CSF) pressure in the absence of any intracranial pathology. IIH mainly affects women with obesity between the age…
View article: The role of brain barriers in fluid movement in the CNS: is there a ‘glymphatic’ system?
The role of brain barriers in fluid movement in the CNS: is there a ‘glymphatic’ system? Open
Brain fluids are rigidly regulated to provide stable environments for neuronal function, e.g., low K+, Ca2+, and protein to optimise signalling and minimise neurotoxicity. At the same time, neuronal and astroglial waste must be promptly re…
View article: Amyloid β synaptotoxicity is Wnt‐PCP dependent and blocked by fasudil
Amyloid β synaptotoxicity is Wnt‐PCP dependent and blocked by fasudil Open
Introduction Synapse loss is the structural correlate of the cognitive decline indicative of dementia. In the brains of Alzheimer's disease sufferers, amyloid β (Aβ) peptides aggregate to form senile plaques but as soluble peptides are tox…
View article: Improved Method for the Establishment of an <em>In Vitro</em> Blood-Brain Barrier Model Based on Porcine Brain Endothelial Cells
Improved Method for the Establishment of an <em>In Vitro</em> Blood-Brain Barrier Model Based on Porcine Brain Endothelial Cells Open
The aim of this protocol presents an optimized procedure for the purification and cultivation of pBECs and to establish in vitro blood-brain barrier (BBB) models based on pBECs in mono-culture (MC), MC with astrocyte-conditioned medium (AC…
View article: Chemotactic synthetic vesicles: Design and applications in blood-brain barrier crossing
Chemotactic synthetic vesicles: Design and applications in blood-brain barrier crossing Open
Brain homing nanoswimmers: Glucose-fueled propulsion combined with blood-brain barrier crossing enhances brain delivery.
View article: Effects of transthyretin on thyroxine and β‐amyloid removal from cerebrospinal fluid in mice
Effects of transthyretin on thyroxine and β‐amyloid removal from cerebrospinal fluid in mice Open
Summary Transthyretin ( TTR ) is a binding protein for the thyroid hormone thyroxine (T 4 ), retinol and β‐amyloid peptide. TTR aids the transfer of T 4 from the blood to the cerebrospinal fluid ( CSF ), but also prevents T 4 loss from the…
View article: Kinetics of functionalised carbon nanotube distribution in mouse brain after systemic injection: Spatial to ultra-structural analyses
Kinetics of functionalised carbon nanotube distribution in mouse brain after systemic injection: Spatial to ultra-structural analyses Open
Earlier studies proved the success of using chemically functionalised multi-walled carbon nanotubes (f-MWNTs) as nanocarriers to the brain. Little insight into the kinetics of brain distribution of f-MWNTs in vivo has been reported. This s…