Jane Frederick
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View article: Leveraging chromatin packing domains to target chemoevasion in vivo
Leveraging chromatin packing domains to target chemoevasion in vivo Open
Cancer cells exhibit a remarkable resilience to cytotoxic stress, often adapting through transcriptional changes linked to alterations in chromatin structure. In several types of cancer, these adaptations involve epigenetic modifications a…
View article: Three-color single-molecule localization microscopy in chromatin
Three-color single-molecule localization microscopy in chromatin Open
Super-resolution microscopy has revolutionized our ability to visualize structures below the diffraction limit of conventional optical microscopy and is particularly useful for investigating complex biological targets like chromatin. Chrom…
View article: Chromatin Organization Governs Transcriptional Response and Plasticity of Cancer Stem Cells
Chromatin Organization Governs Transcriptional Response and Plasticity of Cancer Stem Cells Open
Chromatin organization regulates transcription to influence cellular plasticity and cell fate. We explored whether chromatin nanoscale packing domains are involved in stemness and response to chemotherapy. Using an optical spectroscopic na…
View article: Chromatin conformation, gene transcription, and nucleosome remodeling as an emergent system
Chromatin conformation, gene transcription, and nucleosome remodeling as an emergent system Open
In single cells, variably sized nanoscale chromatin structures are observed, but it is unknown whether these form a cohesive framework that regulates RNA transcription. Here, we demonstrate that the human genome is an emergent, self-assemb…
View article: Leveraging chromatin packing domains to target chemoevasion<i>in vivo</i>
Leveraging chromatin packing domains to target chemoevasion<i>in vivo</i> Open
Cancer cells exhibit a remarkable resilience to cytotoxic stress, often adapting through transcriptional changes linked to alterations in chromatin structure. In several types of cancer, these adaptations involve epigenetic modifications a…
View article: Three-color single-molecule localization microscopy in chromatin
Three-color single-molecule localization microscopy in chromatin Open
Super-resolution microscopy has revolutionized our ability to visualize structures below the diffraction limit of conventional optical microscopy and is particularly useful for investigating complex biological targets like chromatin. Chrom…
View article: Formamide denaturation of double-stranded DNA for fluorescence in situ hybridization (FISH) distorts nanoscale chromatin structure
Formamide denaturation of double-stranded DNA for fluorescence in situ hybridization (FISH) distorts nanoscale chromatin structure Open
As imaging techniques rapidly evolve to probe nanoscale genome organization at higher resolution, it is critical to consider how the reagents and procedures involved in sample preparation affect chromatin at the relevant length scales. Her…
View article: Deep learning-based spectroscopic single-molecule localization microscopy
Deep learning-based spectroscopic single-molecule localization microscopy Open
We demonstrate the feasibility of deep learning-based reconstruction for sSMLM imaging applicable to label-free and fluorescence-labeled sSMLM imaging data. We anticipate our technique will be a valuable tool for high-quality super-resolut…
View article: Formamide denaturation of double-stranded DNA for fluorescence<i>in situ</i>hybridization (FISH) distorts nanoscale chromatin structure
Formamide denaturation of double-stranded DNA for fluorescence<i>in situ</i>hybridization (FISH) distorts nanoscale chromatin structure Open
As imaging techniques rapidly evolve to probe nanoscale genome organization at higher resolution, it is critical to consider how the reagents and procedures involved in sample preparation affect chromatin at the relevant length scales. Her…
View article: Spike-in normalization for single-cell RNA-seq reveals dynamic global transcriptional activity mediating anticancer drug response
Spike-in normalization for single-cell RNA-seq reveals dynamic global transcriptional activity mediating anticancer drug response Open
The transcriptional plasticity of cancer cells promotes intercellular heterogeneity in response to anticancer drugs and facilitates the generation of subpopulation surviving cells. Characterizing single-cell transcriptional heterogeneity a…
View article: Chromatin Reprogramming via Contact Guidance-Induced Nuclear Deformation Promotes Stem Cell Differentiation
Chromatin Reprogramming via Contact Guidance-Induced Nuclear Deformation Promotes Stem Cell Differentiation Open
Efficient manipulation of cell fate is important for regenerative engineering applications. Lineage-specific differentiation of stem cells is particularly challenging due to their inherent plasticity. Engineered topographies may alter cell…
View article: Spike-in normalization for single-cell RNA-seq reveals dynamic global transcriptional activity mediating anti-cancer drug response
Spike-in normalization for single-cell RNA-seq reveals dynamic global transcriptional activity mediating anti-cancer drug response Open
The transcriptional plasticity of cancer cells promotes intercellular heterogeneity in response to anti-cancer drugs and facilitates the generation of subpopulation surviving cells. Characterizing single-cell transcriptional heterogeneity …
View article: Nanoscale chromatin imaging and analysis platform bridges 4D chromatin organization with molecular function
Nanoscale chromatin imaging and analysis platform bridges 4D chromatin organization with molecular function Open
nano-ChIA combines multiple nanoimaging modalities to uncover 4D chromatin organization and its relationship to molecular function.
View article: Nanoscale Chromatin Imaging and Analysis (nano-ChIA) platform bridges 4-D chromatin organization with molecular function
Nanoscale Chromatin Imaging and Analysis (nano-ChIA) platform bridges 4-D chromatin organization with molecular function Open
In eukaryotic cells, chromatin structure is linked to transcription processes through the regulation of genome organization. Extending across multiple length-scales - from the nucleosome to higher-order three-dimensional structures - chrom…
View article: Disordered chromatin packing regulates phenotypic plasticity
Disordered chromatin packing regulates phenotypic plasticity Open
The CPMC model demonstrates the regulatory role of chromatin’s physical structure on transcription and phenotypic plasticity.
View article: Tracking Photodynamic- and Chemotherapy-Induced Redox-State Perturbations in 3D Culture Models of Pancreatic Cancer: A Tool for Identifying Therapy-Induced Metabolic Changes
Tracking Photodynamic- and Chemotherapy-Induced Redox-State Perturbations in 3D Culture Models of Pancreatic Cancer: A Tool for Identifying Therapy-Induced Metabolic Changes Open
The metabolic plasticity of cancer cells is considered a highly advantageous phenotype that is crucial for disease progression and acquisition of treatment resistance. A better understanding of cancer metabolism and its adaptability after …
View article: Shape memory polyurethane‐urea foams with improved toughness
Shape memory polyurethane‐urea foams with improved toughness Open
Current vascular aneurysm treatments often require either highly invasive strategy to surgically occlude an aneurysm or endovascular occlusion via metal coils. While endovascular coils are safer, they have limited efficacy. Endovascular co…
View article: Anticardiolipin Antibodies and Lupus Anticoagulants among Women Undergoing In Vitro Fertilization in Jamaica
Anticardiolipin Antibodies and Lupus Anticoagulants among Women Undergoing In Vitro Fertilization in Jamaica Open
The prevalence of positive aCL and/or LA in infertile women seeking IVF in Jamaica is 7.76%. The presence of these antibodies did not affect the pregnancy rate of these women nor did it demonstrate an increased risk for IVF cycle cancellat…