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Augmented Flow-Induced Outward Remodelling Occurs with Ageing in Mice Open
Outward remodelling of arteries is a feature of cardiovascular pathologies such as atherosclerosis and aneurysm, so a greater understanding of the processes involved in remodelling may aid the development of improved therapies for patients…
In-Situ Vascular Regeneration by Host Cells of Acellular Human Saphenous Vein Implanted in Porcine Carotid Artery Open
Small vascular graft engineering may help reduce early vein graft failure. We assessed the feasibility, safety, and in vivo vascular regeneration potential of the decellularised human saphenous vein (D-hSV) with and without pre-seeding wit…
Understanding and Addressing Procrastination: Analysis from Psychological Research on Factors and Characteristics Associated Open
Exploring factors associated with procrastination is crucial for student life worldwide. This paper examens psychological influences and characteristics related to procrastination, especially focusing on how causal attribution style, emoti…
Establishing a Gynecology Student-Run Free Clinic: A Joint Medical Student and Resident Physician Initiative Open
Dedicated women’s health services are rarely mentioned in the student-run free clinic literature. As society grappled with repeated waves of coronavirus-2019, the number of healthcare professionals decreased across the country and impacted…
A pseudotyped adenovirus serotype 5 vector with serotype 49 fiber knob is an effective vector for vaccine and gene therapy applications Open
Adenoviruses (Ads) have demonstrated significant success as replication-deficient (RD) viral vectored vaccines, as well as broad potential across gene therapy and cancer therapy. Ad vectors transduce human cells via direct interactions bet…
FGL2/FcγRIIB Signalling Mediates Arterial Shear Stress-Mediated Endothelial Cell Apoptosis: Implications for Coronary Artery Bypass Vein Graft Pathogenesis Open
The sudden exposure of venous endothelial cells (vECs) to arterial fluid shear stress (FSS) is thought to be a major contributor to coronary artery bypass vein graft failure (VGF). However, the effects of arterial FSS on the vEC secretome …
WISP-1 Regulates Cardiac Fibrosis by Promoting Cardiac Fibroblasts’ Activation and Collagen Processing Open
Hypertension induces cardiac fibrotic remodelling characterised by the phenotypic switching of cardiac fibroblasts (CFs) and collagen deposition. We tested the hypothesis that Wnt1-inducible signalling pathway protein-1 (WISP-1) promotes C…
Pharmacological Inhibition of MMP-12 Exerts Protective Effects on Angiotensin II-Induced Abdominal Aortic Aneurysms in Apolipoprotein E-Deficient Mice Open
Human abdominal aortic aneurysms (AAAs) are characterized by increased activity of matrix metalloproteinases (MMP), including MMP-12, alongside macrophage accumulation and elastin degradation, in conjunction with superimposed atheroscleros…
The role of FGL2 in vascular smooth muscle cell dysfunction in coronary artery bypass vein graft failure Open
Funding Acknowledgements Type of funding sources: Other. Main funding source(s): British Heart Foundation Rationale The sudden exposure of venous endothelial cells (vECs) to arterial fluid shear stress (FSS) is thought to be a major contri…
Temperature Dependant Mechanical Property Characterisation Using Digital Image Correlation and Infrared Thermography Open
Accurate mechanical property charac-terisation of high-temperature high-performance materials, such as additively manufactured (AM) Inconel 718 (IN718), is crucial to ensure the reliability of components. A sudden drop in strength accompan…
Osteopontin Activation and Microcalcification in Venous Grafts Can Be Modulated by Dexamethasone Open
Background: Osteopontin has been implicated in vascular calcification formation and vein graft intimal hyperplasia, and its expression can be triggered by pro-inflammatory activation of cells. The role of osteopontin and the temporal forma…
Dexamethasone modulate TWIST mediated EndMT changes in venous EC under acute shear stress. Implications for vein grafts disease Open
Background The use of vein grafts in coronary artery surgery is complicated by a high late restenosis rate resulting from the development of intimal hyperplasia, and accelerated atherosclerosis. TGFβ has been implicated in the process of i…
The Role of Preservation Solutions upon Saphenous Vein Endothelial Integrity and Function: Systematic Review and UK Practice Survey Open
The long saphenous vein is the most used conduit in cardiac surgery, but its long-term patency is limited by vein graft disease (VGD). Endothelial dysfunction is a key driver of VGD; its aetiology is multi-factorial. However emerging evide…
Disturbed flow increases endothelial inflammation and permeability via a Frizzled-4-β-catenin-dependent pathway Open
Multidirectional or disturbed flow promotes endothelial dysfunction and is associated with early atherogenesis. Here we investigated the role of Wnt signalling in flow-mediated endothelial dysfunction. The expression of Frizzled-4 was high…
School Of Nursing (S.O.N.), Yola. 2023/2024 Admission form, ☎[070-66280862](2347066280862) Dr (Mrs.) Anita. GENERAL NURSING PROGRAMME Candidates for admission into the General Nursing Education ☎[070-66280862] Programme of the Nursing and Council of Nigeria ☎[070-66280862]must posses the Senior Secondary School Certificate or its equivalent with five credits to include English Language and either Physics, Chemistry, Biology/Health Science at not more than 2 sittings. Duration of Study Three (3) calendar years.☎[070-66280862 Open
School Of Nursing (S.O.N.), Yola. 2023/2024 Admission form, ☎️[070-66280862](2347066280862) Dr (Mrs.) Anita.\nGENERAL NURSING PROGRAMME\nCandidates for admission into the General Nursing Education ☎️[070-66280862] Programme of the Nu…
Inhibition of Intimal Thickening By PRH (Proline-Rich Homeodomain) in Mice Open
Background: Late vein graft failure is caused by intimal thickening resulting from endothelial cell (EC) damage and inflammation which promotes vascular smooth muscle cell (VSMC) dedifferentiation, migration, and proliferation. Nonphosphor…
2023/2024 School of Nursing, Mkar ,Application Form, is out Call ☎[07066280862](07066280862) Dr (Mrs.) Anita. MIDWIFERY FORM: PERIOPERATIVE NURSING, CARDIOTHERACIC NURSING, OPTHAMIC NURSING,ANAESTHETIC NURSING For Registration Guidelines and how to obtain your form Contact the School HELP LINE/ADMIN. Open
2023/2024 School of Nursing, Mkar ,Application Form, is out Call ☎️[07066280862](07066280862) Dr (Mrs.) Anita. MIDWIFERY FORM: PERIOPERATIVE NURSING, CARDIOTHERACIC NURSING, OPTHAMIC NURSING,ANAESTHETIC NURSING For Registration Guidelines …
Pro-inflammatory role of Wnt/β-catenin signaling in endothelial dysfunction Open
Background Endothelial dysfunction is a critical component of both atherosclerotic plaque formation and saphenous vein graft failure. Crosstalk between the pro-inflammatory TNF-α-NFκB signaling axis and the canonical Wnt/β-catenin signalin…
Development and Preliminary Testing of Porcine Blood-Derived Endothelial-like Cells for Vascular Tissue Engineering Applications: Protocol Optimisation and Seeding of Decellularised Human Saphenous Veins Open
Functional endothelial cells (EC) are a critical interface between blood vessels and the thrombogenic flowing blood. Disruption of this layer can lead to early thrombosis, inflammation, vessel restenosis, and, following coronary (CABG) or …
BS17 Glycocalyx depth assessment in pig blood vessels for vein graft applications Open
Introduction Human saphenous veins (hSV) are routinely used during coronary artery bypass grafting, however around 50% of grafted veins occlude 5–10 years post-surgery, often due to platelet aggregation and restenosis. All blood vessels ar…
Next-Generation and Single-Cell Sequencing Approaches to Study Atherosclerosis and Vascular Inflammation Pathophysiology: A Systematic Review Open
Background and Aims Atherosclerosis is a chronic inflammatory disease that remains the leading cause of morbidity and mortality worldwide. Despite decades of research into the development and progression of this disease, current management…
International Journal on AdHoc Networking System (IJANS) Open
In recent years, AdHoc networks have been attracting much interest in both academic and industrial communities. International Journal on AdHoc Networking Systems is an open access peer-reviewed journal that serves as a forum to discuss ong…
New Launch Professional-Cloud-Network-Engineer Dumps - (2022) Professional-Cloud-Network-Engineer Exam Question Open
Mock4solutions Professional-Cloud-Network-Engineer Exam Dumps\n\nThe Professional-Cloud-Network-Engineer exam is one of the hardest exams you can take. Using dumps and practice exams are the best ways to pass. The questions are updated and…