Qin He
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View article: Evaluation of the implementation effect of pre-audit of inpatient medical orders: based on the ORTCC model
Evaluation of the implementation effect of pre-audit of inpatient medical orders: based on the ORTCC model Open
Objective This study aimed to evaluate the impact of implementing a pre-audit system for inpatient medical orders based on the ORTCC (Objectives, Rules, Training, Check, Culture) management model in a tertiary hospital in Chengdu, China. T…
View article: The peptide EPFL8 represses embryonic stomatal precursor formation independently of TOO MANY MOUTHS in Arabidopsis
The peptide EPFL8 represses embryonic stomatal precursor formation independently of TOO MANY MOUTHS in Arabidopsis Open
Plants regulate gas exchange through stomata, which are specialized valves on the aerial epidermis. Stomatal development involves tightly controlled transitions orchestrated by basic helix-loop-helix transcription factors, including SPEECH…
View article: Abnormal ac4C modification in metabolic dysfunction associated steatotic liver cells
Abnormal ac4C modification in metabolic dysfunction associated steatotic liver cells Open
The pathogenesis of metabolic dysfunction-associated steatotic liver disease (MASLD) remains unclear due to the complexity of its etiology. The emerging field of the epitranscriptome has shown significant promise in advancing the understan…
View article: The Potential Mechanism of Kushen Decoction in Treating Haemorrhoids: An Integration of Network Pharmacology, Molecular Docking and Molecular Dynamics Simulation
The Potential Mechanism of Kushen Decoction in Treating Haemorrhoids: An Integration of Network Pharmacology, Molecular Docking and Molecular Dynamics Simulation Open
Kushen decoction (KSD), a traditional Chinese medicine, is extensively utilised for haemorrhoid treatment, yet its underlying mechanisms remain elusive. This study employs a systematic approach to elucidate the therapeutic mechanisms of KS…
View article: Practice and application of learning curve theory in improving prescription review skills in standardized training for pharmacists in medical institutions
Practice and application of learning curve theory in improving prescription review skills in standardized training for pharmacists in medical institutions Open
Objective To explore the practice and application of learning curve theory in improving prescription review skills in standardized training for pharmacists in medical institutions, and to provide reference for enhancing the effectiveness o…
View article: Evaluation on outcomes of Diabetes Treatment Education Services (DTES) provided for patient with type 2 diabetes by pharmacists—Exploration on the transformation of service model of pharmacists in tertiary hospitals
Evaluation on outcomes of Diabetes Treatment Education Services (DTES) provided for patient with type 2 diabetes by pharmacists—Exploration on the transformation of service model of pharmacists in tertiary hospitals Open
Objective To provide reference for the transformation of pharmacists’ working mode from the outpatient pharmacists in the public hospitals to community pharmacists by studying the diabetes treatment education services (DTES) working mode o…
View article: Exploring the anti-atherosclerosis mechanism of ginsenoside Rb1 by integrating network pharmacology and experimental verification
Exploring the anti-atherosclerosis mechanism of ginsenoside Rb1 by integrating network pharmacology and experimental verification Open
Ginsenoside Rb1 is the major active constituent of ginseng, which is widely used in traditional Chinese medicine for the atherosclerosis treatment by anti-inflammatory, anti-oxidant and reducing lipid accumulation. We explored cellular tar…
View article: IGFBPL1 inhibits macrophage lipid accumulation by enhancing the activation of IGR1R/LXRα/ABCG1 pathway
IGFBPL1 inhibits macrophage lipid accumulation by enhancing the activation of IGR1R/LXRα/ABCG1 pathway Open
Lipid accumulation in macrophages plays an important role in atherosclerosis and is the major cause of atherosclerotic cardiovascular disease. Reducing lipid accumulation in macrophages is an effective therapeutic target for atherosclerosi…
View article: Rheumatoid arthritis and heart failure: A bidirectional two-sample Mendelian randomization study
Rheumatoid arthritis and heart failure: A bidirectional two-sample Mendelian randomization study Open
Background: Extensive observational studies suggested an association between rheumatoid arthritis (RA) and heart failure (HF). Nevertheless, whether there was a solid causal association was still unclear because of confounding factors. The…
View article: Exploring the common genetic architecture of autism spectrum disorder using a novel multi-polygenic risk score approach
Exploring the common genetic architecture of autism spectrum disorder using a novel multi-polygenic risk score approach Open
Compared to disorders of similar heritability and contribution of common variants, few genome-wide significant loci have been implicated in autism spectrum disorder (ASD). This undermines the use of polygenic risk scores (PRSs) to investig…
View article: Supplementary Methods, Figures 1-2, Tables 1-3 from Contribution of Beta-HPV Infection and UV Damage to Rapid-Onset Cutaneous Squamous Cell Carcinoma during BRAF-Inhibition Therapy
Supplementary Methods, Figures 1-2, Tables 1-3 from Contribution of Beta-HPV Infection and UV Damage to Rapid-Onset Cutaneous Squamous Cell Carcinoma during BRAF-Inhibition Therapy Open
Supplementary Methods, Figures 1-2, Tables 1-3. Phylogenetic analysis, novel HPV alignment and NGS gene panel. Figure S1 - β-genus HPV38, HPV17 and HPV111 are most frequently found in BRAFi-cSCC; Figure S2: Protein and nucleic acid sequenc…
View article: Supplementary Methods, Figures 1-2, Tables 1-3 from Contribution of Beta-HPV Infection and UV Damage to Rapid-Onset Cutaneous Squamous Cell Carcinoma during BRAF-Inhibition Therapy
Supplementary Methods, Figures 1-2, Tables 1-3 from Contribution of Beta-HPV Infection and UV Damage to Rapid-Onset Cutaneous Squamous Cell Carcinoma during BRAF-Inhibition Therapy Open
Supplementary Methods, Figures 1-2, Tables 1-3. Phylogenetic analysis, novel HPV alignment and NGS gene panel. Figure S1 - β-genus HPV38, HPV17 and HPV111 are most frequently found in BRAFi-cSCC; Figure S2: Protein and nucleic acid sequenc…
View article: Supplementary Tables 1-3 from Cloning and Characterization of a p53 and DNA Damage Down-regulated Gene <i>PIQ</i> that Codes for a Novel Calmodulin-Binding IQ Motif Protein and Is Up-regulated in Gastrointestinal Cancers
Supplementary Tables 1-3 from Cloning and Characterization of a p53 and DNA Damage Down-regulated Gene <i>PIQ</i> that Codes for a Novel Calmodulin-Binding IQ Motif Protein and Is Up-regulated in Gastrointestinal Cancers Open
Supplementary Tables 1-3 from Cloning and Characterization of a p53 and DNA Damage Down-regulated Gene PIQ that Codes for a Novel Calmodulin-Binding IQ Motif Protein and Is Up-regulated in Gastrointestinal Cancers
View article: Supplementary Tables 1-3 from Cloning and Characterization of a p53 and DNA Damage Down-regulated Gene <i>PIQ</i> that Codes for a Novel Calmodulin-Binding IQ Motif Protein and Is Up-regulated in Gastrointestinal Cancers
Supplementary Tables 1-3 from Cloning and Characterization of a p53 and DNA Damage Down-regulated Gene <i>PIQ</i> that Codes for a Novel Calmodulin-Binding IQ Motif Protein and Is Up-regulated in Gastrointestinal Cancers Open
Supplementary Tables 1-3 from Cloning and Characterization of a p53 and DNA Damage Down-regulated Gene PIQ that Codes for a Novel Calmodulin-Binding IQ Motif Protein and Is Up-regulated in Gastrointestinal Cancers
View article: Hatched Eggshell Membrane Can Be a Novel Source of Antioxidant Hydrolysates to Protect against H2O2-Induced Oxidative Stress in Human Chondrocytes
Hatched Eggshell Membrane Can Be a Novel Source of Antioxidant Hydrolysates to Protect against H2O2-Induced Oxidative Stress in Human Chondrocytes Open
Natural antioxidants derived from agricultural by-products have great promise and ecological advantages in the treatment of oxidative stress-related diseases. The eggshell membrane (ESM) from hatched eggs, i.e., the hatched ESM, is a globa…
View article: The Application of Implicit Stratified Teaching to English Reading Teaching in Junior Middle School
The Application of Implicit Stratified Teaching to English Reading Teaching in Junior Middle School Open
Under the current teaching system in China, teachers are still adopting the same teaching contents, teaching objectives, teaching activities and the same evaluation methods to all the students in one class.This will probably make highlevel…
View article: Characterization of the blood and neutrophil‐specific microbiomes and exploration of potential bacterial biomarkers for sepsis in surgical patients
Characterization of the blood and neutrophil‐specific microbiomes and exploration of potential bacterial biomarkers for sepsis in surgical patients Open
Introduction Recent studies have demonstrated the presence of a circulating microbiome in the blood of healthy subjects and chronic inflammatory patients. However, our knowledge regarding the blood microbiome and its potential roles in sur…
View article: Additional file 1 of FOXC1 promotes HCC proliferation and metastasis by Upregulating DNMT3B to induce DNA Hypermethylation of CTH promoter
Additional file 1 of FOXC1 promotes HCC proliferation and metastasis by Upregulating DNMT3B to induce DNA Hypermethylation of CTH promoter Open
Additional file 1: Supplementary Table S1. List of genes differentially expressed in Huh7-FOXC1 versus Huh7-control cells using a human amino acid metabolism PCR array. Supplementary Table S2. List of genes differentially expressed in MHCC…
View article: Additional file 2 of FOXC1 promotes HCC proliferation and metastasis by Upregulating DNMT3B to induce DNA Hypermethylation of CTH promoter
Additional file 2 of FOXC1 promotes HCC proliferation and metastasis by Upregulating DNMT3B to induce DNA Hypermethylation of CTH promoter Open
Additional file 2: Supplementary Figure S1, Supplementary Figure S2, Supplementary Figure S3, Supplementary Figure S4, Supplementary Figure S5.
View article: Conserved Imprinted Genes between Intra-Subspecies and Inter-Subspecies Are Involved in Energy Metabolism and Seed Development in Rice
Conserved Imprinted Genes between Intra-Subspecies and Inter-Subspecies Are Involved in Energy Metabolism and Seed Development in Rice Open
Genomic imprinting is an epigenetic phenomenon in which a subset of genes express dependent on the origin of their parents. In plants, it is unclear whether imprinted genes are conserved between subspecies in rice. Here we identified impri…
View article: MicroRNA-21 Mediates a Positive Feedback on Angiotensin II-Induced Myofibroblast Transformation
MicroRNA-21 Mediates a Positive Feedback on Angiotensin II-Induced Myofibroblast Transformation Open
Dongjiu Li,1,* Chengyu Mao,1,* En Zhou,1,* Jiayin You,2,* Erhe Gao,3 Zhihua Han,1 Yuqi Fan,1 Qing He,1 Changqian Wang1 1Department of Cardiology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai …
View article: Transcriptomic Changes Resulting From STK32B Overexpression Identify Pathways Potentially Relevant to Essential Tremor
Transcriptomic Changes Resulting From STK32B Overexpression Identify Pathways Potentially Relevant to Essential Tremor Open
Objective: Essential tremor (ET) is a common movement disorder that has a high heritability. A number of genetic studies have associated different genes and loci with ET, but few have investigated the biology of any of these genes. STK32B …
View article: Long‐term safety, efficacy, and quality of life outcomes with adjunctive brivaracetam treatment at individualized doses in patients with epilepsy: An up to 11‐year, open‐label, follow‐up trial
Long‐term safety, efficacy, and quality of life outcomes with adjunctive brivaracetam treatment at individualized doses in patients with epilepsy: An up to 11‐year, open‐label, follow‐up trial Open
Objective To evaluate long‐term safety/tolerability of brivaracetam at individualized doses ≤200 mg/d (primary) and maintenance of efficacy over time (secondary) in adults with focal seizures or primary generalized seizures (PGS) enrolled …