Jane Hubert
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View article: From Coffee Waste to Active Ingredient for Cosmetic Applications
From Coffee Waste to Active Ingredient for Cosmetic Applications Open
Coffee silverskin (CS) is the thin epidermis covering and protecting the coffee bean and it represents the main by-product of the coffee roasting process. CS has recently gained attention due to its high content in bioactive molecules and …
View article: Enzymatic Synthesis of α-Glucosyl-Baicalin through Transglucosylation via Cyclodextrin Glucanotransferase in Water
Enzymatic Synthesis of α-Glucosyl-Baicalin through Transglucosylation via Cyclodextrin Glucanotransferase in Water Open
Baicalin is a biologically active flavone glucuronide with poor water solubility that can be enhanced via glucosylation. In this study, the transglucosylation of baicalin was successfully achieved with CGTases from Thermoanaerobacter sp. a…
View article: Anti-<i>Toxoplasma gondii</i> effect of lupane-type triterpenes from the bark of black alder (<i>Alnus glutinosa</i>) and identification of a potential target by reverse docking
Anti-<i>Toxoplasma gondii</i> effect of lupane-type triterpenes from the bark of black alder (<i>Alnus glutinosa</i>) and identification of a potential target by reverse docking Open
Toxoplasmosis is a worldwide parasitosis that is generally benign. The infestation may pose a risk to immunocompromized patients and to fetuses when pregnant women have recently seroconverted. Current treatments have numerous side effects …
View article: Bacterial rhamnolipids and their 3-hydroxyalkanoate precursors activate <i>Arabidopsis</i> innate immunity through two independent mechanisms
Bacterial rhamnolipids and their 3-hydroxyalkanoate precursors activate <i>Arabidopsis</i> innate immunity through two independent mechanisms Open
Significance Activation of plant innate immunity relies on the perception of microorganisms through elicitors. Rhamnolipids and their precursor HAAs are exoproducts produced by bacteria. They are involved in bacterial surface dissemination…
View article: Bio-guided Studies of <i>Lotus maritimus</i> Aerial Parts and Investigation oftheir Antioxidant, Tyrosinase and Elastase Inhibitory Activities
Bio-guided Studies of <i>Lotus maritimus</i> Aerial Parts and Investigation oftheir Antioxidant, Tyrosinase and Elastase Inhibitory Activities Open
Background: Lotus maritimus L. (Fabaceae) is a perennial herb species with yellow flowers, growing in Europe, Asia, Middle East and Maghreb. Some flavones and flavonols have been identified in their leaves and flowers. Their leaf extract w…
View article: The bacterial virulence factors rhamnolipids and their (<i>R</i>)-3-hydroxyalkanoate precursors activate<i>Arabidopsis</i>innate immunity through two independent mechanisms
The bacterial virulence factors rhamnolipids and their (<i>R</i>)-3-hydroxyalkanoate precursors activate<i>Arabidopsis</i>innate immunity through two independent mechanisms Open
Plant innate immunity is activated upon perception of invasion pattern molecules by plant cell-surface immune receptors. Several bacteria of the genera Pseudomonas and Burkholderia produce rhamnolipids (RLs) from L- rhamnose and ( R )-3-hy…
View article: Overall renewal of skin lipids with Vetiver extract for a complete anti‐ageing strategy
Overall renewal of skin lipids with Vetiver extract for a complete anti‐ageing strategy Open
Objective Skin lipids are essential in every compartment of the skin where they play a key role in various biological functions. Interestingly, their role is central in the maintenance of hydration which is related to skin barrier function…
View article: Dereplication of Natural Extracts Diluted in Glycerin: Physical Suppression of Glycerin by Centrifugal Partition Chromatography Combined with Presaturation of Solvent Signals in 13C-Nuclear Magnetic Resonance Spectroscopy
Dereplication of Natural Extracts Diluted in Glycerin: Physical Suppression of Glycerin by Centrifugal Partition Chromatography Combined with Presaturation of Solvent Signals in 13C-Nuclear Magnetic Resonance Spectroscopy Open
For scientific, regulatory, and safety reasons, the chemical profile knowledge of natural extracts incorporated in commercial cosmetic formulations is of primary importance. Many extracts are produced or stabilized in glycerin, a practice …
View article: Chemical Profile and Antimicrobial Activity of the Fungus-Growing Termite Strain Macrotermes Bellicosus Used in Traditional Medicine in the Republic of Benin
Chemical Profile and Antimicrobial Activity of the Fungus-Growing Termite Strain Macrotermes Bellicosus Used in Traditional Medicine in the Republic of Benin Open
The fungus growing termite species Macrotermes bellicosus (M. bellicosus) is used in nutrition and traditional medicine in the Republic of Benin for the treatment of infectious and inflammatory diseases. Previous findings demonstrated evid…
View article: Abundant Extractable Metabolites from Temperate Tree Barks: The Specific Antimicrobial Activity of Prunus Avium Extracts
Abundant Extractable Metabolites from Temperate Tree Barks: The Specific Antimicrobial Activity of Prunus Avium Extracts Open
Tree barks are mainly considered as wood wastes from forestry activities, but represent valuable resources as they may contain antimicrobial compounds. Here, we aimed to evaluate the possible antimicrobial activities of bark extracts and t…
View article: Investigation of Antioxidant and Elastase Inhibitory Activities of <i>Geum urbanum</i> Aerial Parts, Chemical Characterization of Extracts Guided by Chemical and Biological Assays
Investigation of Antioxidant and Elastase Inhibitory Activities of <i>Geum urbanum</i> Aerial Parts, Chemical Characterization of Extracts Guided by Chemical and Biological Assays Open
This study presents the bioguided chemical investigation of the 80% aqueous methanol extract of Geum urbanum aerial parts. Liquid–liquid partitioning of this extract in solvents of increasing polarity combined with biological screening sho…
View article: In Vitro and In Vivo Activity of Anogeissus leiocarpa Bark Extract and Isolated Metabolites against Toxoplasma gondii
In Vitro and In Vivo Activity of Anogeissus leiocarpa Bark Extract and Isolated Metabolites against Toxoplasma gondii Open
Toxoplasma gondii, belonging to the Apicomplexa phylum, is a cosmopolitan protozoan parasite that affects at least 30% of the worldʼs population. In West Africa, the leaves and bark of the tree species Anogeissus leiocarpa (DC.) Guill. & P…
View article: Chemical characterization, antioxidant, tyrosinase and elastase inhibitory activities of Colutea arborescens aerial parts guided by chemical and biological assays
Chemical characterization, antioxidant, tyrosinase and elastase inhibitory activities of Colutea arborescens aerial parts guided by chemical and biological assays Open
International audience
View article: Gluconeogenesis is essential for trypanosome development in the tsetse fly vector
Gluconeogenesis is essential for trypanosome development in the tsetse fly vector Open
In the glucose-free environment that is the midgut of the tsetse fly vector, the procyclic form of Trypanosoma brucei primarily uses proline to feed its central carbon and energy metabolism. In these conditions, the parasite needs to produ…
View article: GABA and GABA-Alanine from the Red Microalgae Rhodosorus marinus Exhibit a Significant Neuro-Soothing Activity through Inhibition of Neuro-Inflammation Mediators and Positive Regulation of TRPV1-Related Skin Sensitization
GABA and GABA-Alanine from the Red Microalgae Rhodosorus marinus Exhibit a Significant Neuro-Soothing Activity through Inhibition of Neuro-Inflammation Mediators and Positive Regulation of TRPV1-Related Skin Sensitization Open
The aim of the present study was to investigate the neuro-soothing activity of a water-soluble hydrolysate obtained from the red microalgae Rhodosorus marinus Geitler (Stylonemataceae). Transcriptomic analysis performed on ≈100 genes relat…
View article: Reconstruction of HMBC Correlation Networks: A Novel NMR-Based Contribution to Metabolite Mixture Analysis
Reconstruction of HMBC Correlation Networks: A Novel NMR-Based Contribution to Metabolite Mixture Analysis Open
A new in silico method is introduced for the dereplication of natural metabolite mixtures based on HMBC and HSQC spectra that inform about short-range and long-range H-C correlations occurring in the carbon skeleton of individual chemical …
View article: Discovery of New Inhibitors of Toxoplasma gondii via the Pathogen Box
Discovery of New Inhibitors of Toxoplasma gondii via the Pathogen Box Open
Toxoplasma gondii is a cosmopolitan protozoan parasite which affects approximately 30% of the population worldwide. The drugs currently used against toxoplasmosis are few in number and show several limitations, such as drug intolerance, po…
View article: Cytotoxicity of Labruscol, a New Resveratrol Dimer Produced by Grapevine Cell Suspensions, on Human Skin Melanoma Cancer Cell Line HT-144
Cytotoxicity of Labruscol, a New Resveratrol Dimer Produced by Grapevine Cell Suspensions, on Human Skin Melanoma Cancer Cell Line HT-144 Open
A new resveratrol dimer (1) called labruscol, has been purified by centrifugal partition chromatography of a crude ethyl acetate stilbene extract obtained from elicited grapevine cell suspensions of Vitis labrusca L. cultured in a 14-liter…
View article: Computer‐aided Dereplication and Structure Elucidation of Natural Products at the University of Reims
Computer‐aided Dereplication and Structure Elucidation of Natural Products at the University of Reims Open
Natural product chemistry began in Reims, France, in a pharmacognosy research laboratory whose main emphasis was the isolation and identification of bioactive molecules, following the guidelines of chemotaxonomy. The structure elucidation …
View article: Computer-Aided <sup>13</sup>C NMR Chemical Profiling of Crude Natural Extracts without Fractionation
Computer-Aided <sup>13</sup>C NMR Chemical Profiling of Crude Natural Extracts without Fractionation Open
A computer-aided, 13C NMR-based dereplication method is presented for the chemical profiling of natural extracts without any fractionation. An algorithm was developed in order to compare the 13C NMR chemical shifts obtained from a single r…
View article: Anti-Cancer Activity of Resveratrol and Derivatives Produced by Grapevine Cell Suspensions in a 14 L Stirred Bioreactor
Anti-Cancer Activity of Resveratrol and Derivatives Produced by Grapevine Cell Suspensions in a 14 L Stirred Bioreactor Open
In the present study, resveratrol and various oligomeric derivatives were obtained from a 14 L bioreactor culture of elicited grapevine cell suspensions (Vitis labrusca L.). The crude ethyl acetate stilbene extract obtained from the cultur…
View article: An integrated process for the recovery of high added-value compounds from olive oil using solid support free liquid-liquid extraction and chromatography techniques
An integrated process for the recovery of high added-value compounds from olive oil using solid support free liquid-liquid extraction and chromatography techniques Open
An integrated extraction and purification process for the direct recovery of high added value compounds from extra virgin olive oil (EVOO) is proposed by using solid support free liquid-liquid extraction and chromatography techniques. Two …
View article: Isolation and characterisation of cytotoxic compounds from <i>Euphorbia clementei</i> Boiss.
Isolation and characterisation of cytotoxic compounds from <i>Euphorbia clementei</i> Boiss. Open
A new phorbol-type diterpene ester, 4,20-dideoxy-4α-phorbol-12β-acetate-13α-isobutyrate, in addition to 11 known compounds were isolated from the latex and roots of Euphorbia clementei Boiss. Structure elucidation was performed by comprehe…
View article: Bio-Guided Isolation of Methanol-Soluble Metabolites of Common Spruce (Picea abies) Bark by-Products and Investigation of Their Dermo-Cosmetic Properties
Bio-Guided Isolation of Methanol-Soluble Metabolites of Common Spruce (Picea abies) Bark by-Products and Investigation of Their Dermo-Cosmetic Properties Open
Common spruce (Picea abies L.) is a fast-growing coniferous tree, widely used in several countries for the production of sawn wood, timber and pulp. During this industrial exploitation, large quantities of barks are generated as waste mate…
View article: In Vitro Dermo-Cosmetic Evaluation of Bark Extracts from Common Temperate Trees
In Vitro Dermo-Cosmetic Evaluation of Bark Extracts from Common Temperate Trees Open
Wood residues produced from forestry activities represent an interesting source of biologically active, high value-added secondary metabolites. In this study, 30 extracts from 10 barks of deciduous and coniferous tree species were investig…
View article: Fast Identification of Radical Scavengers from Securigera varia by Combining 13C-NMR-Based Dereplication to Bioactivity-Guided Fractionation
Fast Identification of Radical Scavengers from Securigera varia by Combining 13C-NMR-Based Dereplication to Bioactivity-Guided Fractionation Open
Securigera varia (Fabaceae) is a common herbaceous perennial plant widely growing in Europe and Asia and purposely established for erosion control, roadside planting, and soil rehabilitation. The aim of this study was to determine the radi…
View article: Exploiting the Complementarity between Dereplication and Computer-Assisted Structure Elucidation for the Chemical Profiling of Natural Cosmetic Ingredients:<i>Tephrosia purpurea</i>as a Case Study
Exploiting the Complementarity between Dereplication and Computer-Assisted Structure Elucidation for the Chemical Profiling of Natural Cosmetic Ingredients:<i>Tephrosia purpurea</i>as a Case Study Open
The aqueous-ethanolic extract of Tephrosia purpurea seeds is currently exploited in the cosmetic industry as a natural ingredient of skin lotions. The aim of this study was to chemically characterize this ingredient by combining centrifuga…