Jane J. Border
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View article: SGLT2 Inhibition Protects Cognitive Function in Alzheimer's Disease by Enhancing Brain Perfusion, Independent of Glucose Control
SGLT2 Inhibition Protects Cognitive Function in Alzheimer's Disease by Enhancing Brain Perfusion, Independent of Glucose Control Open
Background SGLT2 inhibitors were initially approved by the FDA to lower blood sugar in type 2 diabetes. Later clinical trials showed significant benefits in treating heart failure, even in patients without uncontrolled diabetes. Recent evi…
View article: Dual Inhibition of sEH and COX-2 Improved Cognition in Alzheimer’s Disease via Enhanced Myogenic Response and Cerebral Artery Distensibility
Dual Inhibition of sEH and COX-2 Improved Cognition in Alzheimer’s Disease via Enhanced Myogenic Response and Cerebral Artery Distensibility Open
Genetic studies have linked EPHX2 (encoding soluble epoxide hydrolase, sEH) and PTGS2 (encoding cyclooxygenase-2, COX-2) to Alzheimer’s disease (AD). Elevated levels of sEH and COX-2 found in AD patients and animals suggest their involveme…
View article: A Soluble Epoxide Hydrolase Inhibitor Improves Cerebrovascular Dysfunction, Neuroinflammation, Amyloid Burden, and Cognitive Impairments in the hAPP/PS1 TgF344-AD Rat Model of Alzheimer’s Disease
A Soluble Epoxide Hydrolase Inhibitor Improves Cerebrovascular Dysfunction, Neuroinflammation, Amyloid Burden, and Cognitive Impairments in the hAPP/PS1 TgF344-AD Rat Model of Alzheimer’s Disease Open
Alzheimer’s disease (AD) is an increasing global healthcare crisis with few effective treatments. The accumulation of amyloid plaques and hyper-phosphorylated tau are thought to underlie the pathogenesis of AD. However, current studies hav…
View article: CD14 in Salt‐Sensitive Hypertension‐Related Cognitive Impairments
CD14 in Salt‐Sensitive Hypertension‐Related Cognitive Impairments Open
Background Hypertension is a leading risk factor for the development of Alzheimer’s disease and Alzheimer’s disease‐related dementia (AD/ADRD), which is closely linked with cerebral vascular inflammation and dysfunction. We previously foun…
View article: Inhibition of Soluble Epoxide Hydrolase Ameliorates Cerebral Blood Flow Autoregulation and Cognition in Alzheimer’s Disease and Diabetes-Related Dementia Rat Models
Inhibition of Soluble Epoxide Hydrolase Ameliorates Cerebral Blood Flow Autoregulation and Cognition in Alzheimer’s Disease and Diabetes-Related Dementia Rat Models Open
Alzheimer’s Disease and Alzheimer’s Disease-related dementias (AD/ADRD) pose major global healthcare challenges, with diabetes mellitus (DM) being a key risk factor. Both AD and DM-related ADRD are characterized by reduced cerebral blood f…
View article: Role of<i>Dusp</i>5 KO on Vascular Properties of Middle Cerebral Artery in Rats
Role of<i>Dusp</i>5 KO on Vascular Properties of Middle Cerebral Artery in Rats Open
Vascular aging influences hemodynamics, elevating risks for vascular diseases and dementia. We recently demonstrated that knockout (KO) of Dusp5 enhances cerebral and renal hemodynamics and cognitive function. This improvement correlates w…
View article: AT1-AA Infusion during Pregnancy Impairs CBF Autoregulation Postpartum
AT1-AA Infusion during Pregnancy Impairs CBF Autoregulation Postpartum Open
Preeclampsia (PE), new-onset hypertension during pregnancy alongside organ dysfunction, is a leading cause of morbidity and mortality for the mother and fetus. PE women have activated B cells that produce agonistic autoantibodies to the an…
View article: Enhanced Cerebral Hemodynamics and Cognitive Function Via Knockout of Dual-Specificity Protein Phosphatase 5
Enhanced Cerebral Hemodynamics and Cognitive Function Via Knockout of Dual-Specificity Protein Phosphatase 5 Open
Alzheimer's Disease (AD) and Alzheimer's Disease-Related Dementias (ADRD) are neurodegenerative disorders. Recent studies suggest that cerebral hypoperfusion is an early symptom of AD/ADRD. Dual-specificity protein phosphatase 5 (DUSP5) ha…
View article: Longitudinal Characterization of Cerebral Hemodynamics in the TgF344-AD Rat Model of Alzheimer’s Disease
Longitudinal Characterization of Cerebral Hemodynamics in the TgF344-AD Rat Model of Alzheimer’s Disease Open
Alzheimer’s Disease (AD) is a global healthcare crisis. The TgF344-AD rat is an AD model exhibiting age-dependent AD pathological hallmarks. We confirmed that AD rats developed cognitive deficits at 6 months without alteration of any other…
View article: Impact of impaired cerebral blood flow autoregulation on cognitive impairment
Impact of impaired cerebral blood flow autoregulation on cognitive impairment Open
Although the causes of cognitive impairment are multifactorial, emerging evidence indicates that cerebrovascular dysfunction plays an essential role in dementia. One of the most critical aspects of cerebrovascular dysfunction is autoregula…
View article: Luseogliflozin, a sodium-glucose cotransporter-2 inhibitor, reverses cerebrovascular dysfunction and cognitive impairments in 18-mo-old diabetic animals
Luseogliflozin, a sodium-glucose cotransporter-2 inhibitor, reverses cerebrovascular dysfunction and cognitive impairments in 18-mo-old diabetic animals Open
This study demonstrates that luseogliflozin, a sodium-glucose cotransporter-2 inhibitor, improved CBF autoregulation in association with reduced vascular oxidative stress and AGEs production in the cerebrovasculature of 18-mo-old DM rats. …