Jane Munro
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View article: Stochastic epigenetic mutation profiles as biomarkers of clinical activity in juvenile idiopathic arthritis: a multi-omic machine learning approach for gene prioritization
Stochastic epigenetic mutation profiles as biomarkers of clinical activity in juvenile idiopathic arthritis: a multi-omic machine learning approach for gene prioritization Open
Background Juvenile idiopathic arthritis (JIA) is a rare autoimmune disease arising from a complex interplay between genetic and environmental factors. Epigenetic modifications such as DNA methylation (DNAm) have been described as potentia…
View article: Disease modifying anti-rheumatic drug treatment cycles and rates of flare in juvenile idiopathic arthritis—a tale of Sisyphean endeavour?
Disease modifying anti-rheumatic drug treatment cycles and rates of flare in juvenile idiopathic arthritis—a tale of Sisyphean endeavour? Open
Objectives Withdrawal of DMARD therapy to determine need for ongoing medication is common in JIA management. Little is known about how often patients undergo trials of medication discontinuation or the outcomes of successive trials. This s…
View article: Breadth and visibility of children’s lower limb chronic musculoskeletal pain: a scoping review
Breadth and visibility of children’s lower limb chronic musculoskeletal pain: a scoping review Open
Objective To identify the types of conditions reported in peer-reviewed literature that result in chronic musculoskeletal lower limb pain in children and adolescents and explore the alignment of these conditions with the chronic pain repor…
View article: Three‐ and five‐year outcomes of an inception cohort of Australian children with juvenile idiopathic arthritis
Three‐ and five‐year outcomes of an inception cohort of Australian children with juvenile idiopathic arthritis Open
Background To describe the 3‐ and 5‐year outcomes of an inception cohort of Australian children with JIA for whom 1‐year outcomes have previously been published. Methods Data regarding clinical outcomes of the original cohort of 134 patien…
View article: The plasma metabolome of systemic juvenile idiopathic arthritis is different to non-JIA controls and partially explained by chronic inflammation
The plasma metabolome of systemic juvenile idiopathic arthritis is different to non-JIA controls and partially explained by chronic inflammation Open
Background: Diagnosis of juvenile idiopathic arthritis (JIA) is challenging due to shared clinical features between subtypes and with other inflammatory conditions. A molecular signature may therefore be useful for subtype classification i…
View article: Methotrexate for juvenile idiopathic arthritis
Methotrexate for juvenile idiopathic arthritis Open
Oral methotrexate (5 mg/m2/week to 15 mg/m2/week) compared with placebo may increase the number of children and young people achieving treatment response but may have little or no effect on pain or participant global assessment of well-bei…
View article: Factors impacting COVID-19 vaccine decision making in older adults and people with underlying conditions in Victoria, Australia: A cross-sectional survey
Factors impacting COVID-19 vaccine decision making in older adults and people with underlying conditions in Victoria, Australia: A cross-sectional survey Open
Australia's COVID-19 vaccine rollout included prioritizing older adults and those with underlying conditions. However, little was known around the factors impacting their decision to accept the vaccine. This study aimed to assess vaccine i…
View article: Modified Delphi study to identify priority clinical questions for the Australian living guidelines for the management of Juvenile Idiopathic Arthritis
Modified Delphi study to identify priority clinical questions for the Australian living guidelines for the management of Juvenile Idiopathic Arthritis Open
Background Juvenile Idiopathic Arthritis (JIA) is the most common rheumatic inflammatory disease in childhood. Optimal management requires clinicians to be up to date with the rapidly evolving evidence base. ‘Living’ evidence-based clinica…
View article: Identification of Novel Loci Shared by Juvenile Idiopathic Arthritis Subtypes Through Integrative Genetic Analysis
Identification of Novel Loci Shared by Juvenile Idiopathic Arthritis Subtypes Through Integrative Genetic Analysis Open
Objective Juvenile idiopathic arthritis (JIA) is the most common chronic immune‐mediated joint disease among children and encompasses a heterogeneous group of immune‐mediated joint disorders classified into 7 subtypes according to clinical…
View article: Dose reduction and discontinuation of disease-modifying anti-rheumatic drugs (DMARDs) for juvenile idiopathic arthritis
Dose reduction and discontinuation of disease-modifying anti-rheumatic drugs (DMARDs) for juvenile idiopathic arthritis Open
This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To assess the benefits and harms of dose reduction or discontinuation of disease‐modifying anti‐rheumatic drugs in children and young people with clini…
View article: Factors Influencing Australian Healthcare Workers’ COVID-19 Vaccine Intentions across Settings: A Cross-Sectional Survey
Factors Influencing Australian Healthcare Workers’ COVID-19 Vaccine Intentions across Settings: A Cross-Sectional Survey Open
Healthcare workers’ COVID-19 vaccination coverage is important for staff and patient safety, workforce capacity and patient uptake. We aimed to identify COVID-19 vaccine intentions, factors associated with uptake and information needs for …
View article: High levels of psychosocial distress among Australian frontline healthcare workers during the COVID-19 pandemic: a cross-sectional survey
High levels of psychosocial distress among Australian frontline healthcare workers during the COVID-19 pandemic: a cross-sectional survey Open
Background The coronavirus disease 2019 (COVID-19) pandemic has had a profound and prolonged impact on healthcare services and healthcare workers. Aims The Australian COVID-19 Frontline Healthcare Workers Study aimed to investigate the sev…
View article: Movement Through Disorientation: The De-stress Through Movement Activity Pack Created for Music in Detention
Movement Through Disorientation: The De-stress Through Movement Activity Pack Created for Music in Detention Open
Movement through Disorientation” is a visual essay that presents images from—and discusses the co-authorship of—the activity pack De-Stress through Movement. The essay is a reflection, sometimes through interview format with a co-facilitat…
View article: Gender Equity in Australian Health Leadership
Gender Equity in Australian Health Leadership Open
Objective: To ascertain the gender distribution across public health boards in Australia. Design & Setting: Analysis of data and information obtained from a cross sectional audit of online publicly listed health boards within Australia fro…
View article: Integrative Genetics Analysis of Juvenile Idiopathic Arthritis Identifies Novel Loci
Integrative Genetics Analysis of Juvenile Idiopathic Arthritis Identifies Novel Loci Open
Juvenile Idiopathic Arthritis (JIA) is the most common type of arthritis among children, encompassing a highly heterogeneous group of immune-mediated joint disorders, being classified into seven subtypes based on clinical presentation. To …
View article: Genomic risk scores for juvenile idiopathic arthritis and its subtypes
Genomic risk scores for juvenile idiopathic arthritis and its subtypes Open
Aims Juvenile idiopathic arthritis (JIA) is an autoimmune disease and a common cause of chronic disability in children. Diagnosis of JIA is based purely on clinical symptoms, leading to treatment delays. Despite JIA having substantial heri…
View article: Establishing an Updated Core Domain Set for Studies in Juvenile Idiopathic Arthritis: A Report from the OMERACT 2018 JIA Workshop
Establishing an Updated Core Domain Set for Studies in Juvenile Idiopathic Arthritis: A Report from the OMERACT 2018 JIA Workshop Open
Objective. The current Juvenile Idiopathic Arthritis (JIA) Core Set used in randomized controlled trials (RCT) and longitudinal observational studies (LOS) was developed without the input of patients/parents. At the Outcome Measures in Rhe…
View article: 260 Globalisation of Paediatric Musculoskeletal Matters (PMM)
260 Globalisation of Paediatric Musculoskeletal Matters (PMM) Open
Background: Paediatric musculoskeletal matters (PMM-www.pmmonline.org) is a free, evidence-based and peer reviewed open e-resource for paediatric musculoskeletal (MSK) medicine targeting non-MSK specialists. Since launch (Nov-2014) PMM has…
View article: 054. Globalisation of Paediatric Musculoskeletal Matters’ (PMM)
054. Globalisation of Paediatric Musculoskeletal Matters’ (PMM) Open
Background: Paediatric musculoskeletal matters (PMM-www.pmmonline.org) is a free, evidence-based and peer reviewed open e-resource for paediatric musculoskeletal (MSK) medicine targeting non-MSK specialists. Since launch (Nov-2014) PMM has…
View article: Evidence for Updating the Core Domain Set of Outcome Measures for Juvenile Idiopathic Arthritis: Report from a Special Interest Group at OMERACT 2016
Evidence for Updating the Core Domain Set of Outcome Measures for Juvenile Idiopathic Arthritis: Report from a Special Interest Group at OMERACT 2016 Open
Objective. The current Juvenile Idiopathic Arthritis (JIA) Core Set was developed in 1997 to identify the outcome measures to be used in JIA clinical trials using statistical and consensus-based techniques, but without patient involvement.…
View article: ASCIA‐P74: AUSTRALIAN AUTOINFLAMMATORY DISEASES REGISTRY (AADRY): A NATIONAL APPROACH TO THE GENETIC AND IMMUNOLOGICAL EVALUATION OF PATIENTS WITH SUSPECTED AUTOINFLAMMATORY DISEASE
ASCIA‐P74: AUSTRALIAN AUTOINFLAMMATORY DISEASES REGISTRY (AADRY): A NATIONAL APPROACH TO THE GENETIC AND IMMUNOLOGICAL EVALUATION OF PATIENTS WITH SUSPECTED AUTOINFLAMMATORY DISEASE Open
Traditionally defined as periodic fever syndromes lacking markers of autoimmunity such as high titre self-reactive T cells and auto-antibodies, the spectrum of monogenic autoinflammatory diseases has broadened substantially in recent years…