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View article: Fabric integrity, net type and risk index predict attrition of insecticide-treated nets: evidence from a community durability trial of pyrethroid-piperonyl butoxide (PBO) nets in Tanzania
Fabric integrity, net type and risk index predict attrition of insecticide-treated nets: evidence from a community durability trial of pyrethroid-piperonyl butoxide (PBO) nets in Tanzania Open
Fabric integrity was the main driver of rapid ITN attrition and the strongest predictor of loss. Damaged nets were approximately twice as likely to be discarded after one year and at least ten times more likely to be lost in years two and …
Durability study of Veeralin®, Olyset® Plus and MAGNet® insecticide-treated nets (ITNs) in Kurnool district, Andhra Pradesh, India Open
Background India plans to eliminate malaria by 2030, targeting zero local cases by 2027. However, malaria remains prevalent in endemic regions. As a means of addressing this issue, insecticide-treated nets (ITNs) are crucial for prevention…
View article: 157 Accelerating veterinary clinical innovation through biobanking.
157 Accelerating veterinary clinical innovation through biobanking. Open
This session will focus on the ways veterinary biobanking can be leveraged to support clinical innovation and discovery in both the veterinary and the translational medicine spaces. It will provide examples of where biobanking has supporte…
View article: The BiteBarrier transfluthrin emanator demonstrates significant protection against susceptible and resistant malaria and arbovirus vectors in semi-field trials in Tanzania
The BiteBarrier transfluthrin emanator demonstrates significant protection against susceptible and resistant malaria and arbovirus vectors in semi-field trials in Tanzania Open
Controlling mosquito-borne diseases is becoming increasingly challenging due to factors such as insecticide resistance and shifts in mosquito behavior. The increasing proportion of early evening, morning, and outdoor biting reduces the eff…
Volatile pyrethroid spatial repellents for preventing mosquito bites: a systematic review and meta-analysis Open
National Institutes of Health (National Institute of Allergy and Infectious Diseases (K01AI156182)) and "Accelerate to Eliminate Malaria" program.
View article: Controlling malaria mosquito reproduction via the octopamine beta2 receptor
Controlling malaria mosquito reproduction via the octopamine beta2 receptor Open
Mosquito reproduction in a broad sense involves multiple steps from acoustic recognition of mating partners to egg hatching. We show that the octopamine receptor AgOctβ2R controls different aspects of this process in a sexually dimorphic m…
View article: Efficacy of the spatial repellent SC Johnson Mosquito Shield™ against anophelines in free-flight chambers, semi-field systems, experimental huts, and in-home tests
Efficacy of the spatial repellent SC Johnson Mosquito Shield™ against anophelines in free-flight chambers, semi-field systems, experimental huts, and in-home tests Open
Background Evaluation of vector control tools follows a phased approach, progressing from laboratory studies to semi-field trials in experimental huts, and finally to small-scale (in-home test) and large-scale (randomized control trials) f…
View article: Impact of artemether–lumefantrine treatment, circadian rhythm, and serum replacement on the infectiousness of wild Plasmodium falciparum gametocytes to Anopheles gambiae sensu stricto mosquitoes
Impact of artemether–lumefantrine treatment, circadian rhythm, and serum replacement on the infectiousness of wild Plasmodium falciparum gametocytes to Anopheles gambiae sensu stricto mosquitoes Open
Background In the era of asymptomatic gametocytemia, carriers are scarce but serve as key reservoirs for Plasmodium falciparum gametocytes. Transmission-blocking interventions (TBIs) are gaining attention, considering factors such as artem…
View article: Developing a Sustainable Community Health Workforce in Arkansas
Developing a Sustainable Community Health Workforce in Arkansas Open
Arkansas faces significant health disparities, including high rates of chronic diseases and limited healthcare access, especially in rural and underserved communities. Community Health Workers (CHWs) serve as essential links between the he…
View article: SC Johnson Guardian™ spatial repellent shows 1-year efficacy against wild pyrethroid-resistant Anopheles arabiensis, with a similar blood-feeding inhibition efficacy to Mosquito Shield™ in a Tanzanian experimental hut trial
SC Johnson Guardian™ spatial repellent shows 1-year efficacy against wild pyrethroid-resistant Anopheles arabiensis, with a similar blood-feeding inhibition efficacy to Mosquito Shield™ in a Tanzanian experimental hut trial Open
Background Spatial repellents (SRs) that passively emanate airborne concentrations of an active ingredient within a space disrupt mosquito behaviors to reduce human-vector contact. A clinical trial of SC Johnson’s Mosquito Shield™ (Mosquit…
View article: A household randomized-control trial of insecticide-treated screening for malaria control in unimproved houses in Tanzania
A household randomized-control trial of insecticide-treated screening for malaria control in unimproved houses in Tanzania Open
The trial was registered at ClinicalTrials.gov (NCT05125133) on October 2021.
View article: DENV-2 Circulation and Host Preference Among Highly Anthropophilic, Outdoor-Biting Aedes aegypti in Dar es Salaam, Tanzania
DENV-2 Circulation and Host Preference Among Highly Anthropophilic, Outdoor-Biting Aedes aegypti in Dar es Salaam, Tanzania Open
In Tanzania, dengue outbreaks have occurred almost annually over the past decade, with each new outbreak becoming more severe. This study investigated the prevalence of dengue virus (DENV) serotypes in the wild Aedes aegypti and their bloo…
View article: Nanobody-mediated targeting of Plasmodium falciparum PfPIMMS43 can block malaria transmission in mosquitoes
Nanobody-mediated targeting of Plasmodium falciparum PfPIMMS43 can block malaria transmission in mosquitoes Open
The transition from ookinete to oocyst is a critical step in the Plasmodium falciparum lifecycle and an important target for malaria transmission-blocking strategies. PfPIMMS43, a surface protein of P. falciparum ookinetes and sporozoites,…
View article: DENV-2 Circulation and Host Preference Among Highly Anthropophilic, Outdoor-Biting <em>Aedes aegypti</em> in Dar es Salaam, Tanzania
DENV-2 Circulation and Host Preference Among Highly Anthropophilic, Outdoor-Biting <em>Aedes aegypti</em> in Dar es Salaam, Tanzania Open
In Tanzania, dengue outbreaks have occurred almost annually over the past decade, with each new outbreak becoming more severe. This study investigated the prevalence of dengue virus (DENV) serotypes in the wild Aedes aegypti and their bloo…
Do long-lasting insecticidal nets retain their efficacy after three years of usage in Afghanistan? Findings from a study on survivorship, physical integrity, insecticidal activity and wash resistance Open
LLIN survivorship and functional net survival in this setting was excellent, while only a minority of LLINs retained sufficient insecticidal activity after three years of usage. This study underlines the need for evaluation of real-life LL…
View article: A household randomised-control trial of insecticide-treated screening for malarial control in unimproved houses in Tanzania
A household randomised-control trial of insecticide-treated screening for malarial control in unimproved houses in Tanzania Open
Background Insecticide-treated screening of gaps, including open eaves, windows, and holes in walls of unimproved houses, prevents mosquitoes' indoor entry, and induces lethal and sub-lethal effects to malaria vectors, and may potentially …
Estimating the hole surface area of insecticide-treated nets using image analysis, manual hole counting and exact hole measurements Open
Images coupled with manual segmentation contain sufficient information to calculate hole surface area. This lays the groundwork for incorporating automatic hole detection, and then assessing whether this method will offer a fast and object…
View article: PRONet Duo insecticide-treated net incorporated with chlorfenapyr and bifenthrin is superior to Interceptor® G2 nets against pyrethroid-resistant Anopheles gambiae sensu lato: a randomized experimental hut trial in Côte d’Ivoire and Tanzania using non-inferiority design
PRONet Duo insecticide-treated net incorporated with chlorfenapyr and bifenthrin is superior to Interceptor® G2 nets against pyrethroid-resistant Anopheles gambiae sensu lato: a randomized experimental hut trial in Côte d’Ivoire and Tanzania using non-inferiority design Open
Background The widespread development of pyrethroid-resistant Anopheles populations, has reduced the efficacy of pyrethroid insecticide-treated nets (ITNs), hindering malaria control efforts. This study tested PRONet Duo, a new ITN with tw…
View article: Community perceptions and acceptability of insecticide-treated screens for mosquito proofing of unimproved houses in Chalinze district, Tanzania: a mixed-methods study
Community perceptions and acceptability of insecticide-treated screens for mosquito proofing of unimproved houses in Chalinze district, Tanzania: a mixed-methods study Open
Background Unimproved housing is a risk factor for malaria. Therefore, netting incorporated with deltamethrin and piperonyl butoxide, supplied as a roll to screen opened eaves, windows, and holes in the walls of unimproved houses, could of…
View article: Cascades of effectiveness of new-generation insecticide-treated nets against malaria, from entomological trials to real-life conditions
Cascades of effectiveness of new-generation insecticide-treated nets against malaria, from entomological trials to real-life conditions Open
As insecticide resistance spreads in Africa, new-generation insecticide-treated nets (ITNs) are increasingly being deployed to protect vulnerable populations against malaria. While these nets provide greater entomological efficacy against …
View article: Elevating larval source management as a key strategy for controlling malaria and other vector-borne diseases in Africa
Elevating larval source management as a key strategy for controlling malaria and other vector-borne diseases in Africa Open
Larval source management (LSM) has a long history of advocacy and successes but is rarely adopted where funds are limited. The World Health Organization (WHO) guidelines on malaria prevention recommend the use of LSM as a supplementary int…
View article: A matter of timing: Biting by malaria-infected Anopheles mosquitoes and the use of interventions during the night in rural south-eastern Tanzania
A matter of timing: Biting by malaria-infected Anopheles mosquitoes and the use of interventions during the night in rural south-eastern Tanzania Open
Knowing when and where infected mosquitoes bite is required for estimating accurate measures of malaria risk, assessing outdoor exposure, and designing intervention strategies. This study combines secondary analyses of a human behaviour su…