Jane Smitham
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View article: Histamine H1 Receptor: A potential therapeutic target for pancreatic ductal adenocarcinoma
Histamine H1 Receptor: A potential therapeutic target for pancreatic ductal adenocarcinoma Open
Patients diagnosed with pancreatic ductal adenocarcinoma (PDAC) have a dismal 5-year survival (∼13%). Thus, new, effective, and ideally, less toxic therapies are desperately needed. Epidemiologic studies have found that patients with PDAC …
View article: GPCR signaling measurement and drug profiling with an automated live‐cell microscopy system
GPCR signaling measurement and drug profiling with an automated live‐cell microscopy system Open
Time‐lapse microscopy combined with genetically encoded fluorescent biosensors is a powerful tool for quantitatively measuring live cell signaling dynamics with high spatial and temporal resolution in single cells, providing rich signaling…