Katrina Williams
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View article: Effectiveness of lifestyle interventions for preventing or managing the adverse cardiometabolic and other physical health effects of antipsychotic medications in children and adolescents: systematic review and meta-analysis
Effectiveness of lifestyle interventions for preventing or managing the adverse cardiometabolic and other physical health effects of antipsychotic medications in children and adolescents: systematic review and meta-analysis Open
Background An increasing number of children and adolescents are prescribed second-generation antipsychotic medications, which may lead to cardiometabolic or other physical health impairments. It is unknown whether lifestyle interventions c…
View article: Utilising linked administrative data to model the impact of stacked early childhood interventions on developmental inequities
Utilising linked administrative data to model the impact of stacked early childhood interventions on developmental inequities Open
ObjectiveTo demonstrate how linked administrative data can be utilised to examine the extent to which stacking multiple policy-relevant hypothetical interventions across early childhood could potentially reduce socioeconomic inequities in …
View article: Sensitivity and Specificity of Developmental Surveillance and Autism Screening in an Australian Multicultural Cohort: The Watch Me Grow Study
Sensitivity and Specificity of Developmental Surveillance and Autism Screening in an Australian Multicultural Cohort: The Watch Me Grow Study Open
To examine accuracy of two-tiered surveillance to detect developmental disability and autism in a multicultural birth cohort; a subset of the Watch Me Grow Study. Surveillance tools were used at or soon after 18 months of age, including th…
View article: Deep developmental phenotyping in children with tuberous sclerosis complex, with and without autism
Deep developmental phenotyping in children with tuberous sclerosis complex, with and without autism Open
Aim To characterize autism and co‐occurring tuberous sclerosis‐associated neuropsychiatric disorders (TAND) in children with tuberous sclerosis complex (TSC), addressing evidence gaps by using deep developmental phenotyping in a single coh…
View article: Epigenomic newborn screening for conditions with intellectual disability and autistic features in Australian newborns
Epigenomic newborn screening for conditions with intellectual disability and autistic features in Australian newborns Open
This study describes a protocol to assess a novel workflow called Epi-Genomic Newborn Screening (EpiGNs) on 100,000 infants from the state of Victoria, Australia. The workflow uses a first-tier screening approach called methylation-specifi…
View article: Simulation-based education for teaching aggression management skills to healthcare providers in acute healthcare settings: A systematic review
Simulation-based education for teaching aggression management skills to healthcare providers in acute healthcare settings: A systematic review Open
Simulation-based education improved acute healthcare clinician knowledge and confidence in managing aggression.
View article: Language growth in verbal autistic children from 5 to 11 years
Language growth in verbal autistic children from 5 to 11 years Open
To examine predictors and growth in language for verbal autistic and non‐autistic children with/without low language from 4 to 11 years. Receptive and expressive language trajectories were compared in a community sample of 1026 children at…
View article: Patterns of Psychotropic Prescribing Practices in Autistic Children and Adolescents: An Australian Perspective of Two Cohorts Five Years Apart
Patterns of Psychotropic Prescribing Practices in Autistic Children and Adolescents: An Australian Perspective of Two Cohorts Five Years Apart Open
This study aims to describe the utilisation of psychotropic medications in Australian autistic children and adolescents. All children and adolescents with available Pharmaceutical Benefits Scheme data who endorsed an autism diagnosis in Th…
View article: Comprehensive care programmes for children with medical complexity
Comprehensive care programmes for children with medical complexity Open
The findings of this review should be treated with caution due to the limited amount and quality of the published research that was available to be included. Overall, the certainty of the evidence for the effectiveness of comprehensive car…
View article: Difficult Toddler Temperament – Prevalence and Associated Factors at 18-Month Follow-Up of a Birth Cohort
Difficult Toddler Temperament – Prevalence and Associated Factors at 18-Month Follow-Up of a Birth Cohort Open
Toddlers with difficult temperament were less likely to have received stimulatory experiences, and their families were more likely to be under greater stress. The findings emphasize the importance of parental support and anticipatory guida…
View article: Fetal alcohol spectrum disorder and attention deficit hyperactivity disorder stimulant trial in children: an N-of-1 pilot trial to compare stimulant to placebo (FASST): protocol
Fetal alcohol spectrum disorder and attention deficit hyperactivity disorder stimulant trial in children: an N-of-1 pilot trial to compare stimulant to placebo (FASST): protocol Open
Introduction Fetal alcohol spectrum disorder (FASD) is a neurodevelopmental disorder caused by alcohol exposure during pregnancy. FASD is associated with neurodevelopmental deviations, and 50%–94% of children with FASD meet the Diagnostic …
View article: Diagnostic findings and yield of investigations for children with developmental regression
Diagnostic findings and yield of investigations for children with developmental regression Open
Childhood conditions that feature developmental regression are poorly understood. Phenotype–genotype characterization and diagnostic yield data are needed to inform clinical decision‐making. The aim of this study was to report the conditio…
View article: A Preliminary Trial of an Early Surveillance Program for Autism and Developmental Delays within General Practices
A Preliminary Trial of an Early Surveillance Program for Autism and Developmental Delays within General Practices Open
There are inequities in engagement with established early childhood developmental surveillance programs, eclipsing disadvantaged families. The current study sought to address this by dovetailing developmental surveillance with immunization…
View article: Developmental Regression in Children: A Scoping Review of Definitions and Measures
Developmental Regression in Children: A Scoping Review of Definitions and Measures Open
BACKGROUND Developmental regression in children is a concerning symptom as may be an early indication of a neurodevelopmental or neurodegenerative condition or a developmental epileptic encephalopathy. The heterogeneity of conditions that …
View article: Shepherding parents to prepare for end-of-life decision-making: a critical phenomenological study of the communication approach of paediatricians caring for children with life-limiting conditions in Australia
Shepherding parents to prepare for end-of-life decision-making: a critical phenomenological study of the communication approach of paediatricians caring for children with life-limiting conditions in Australia Open
Background/objectives Shared decision-making is widely accepted as the best approach for end-of-life decision-making for children with life-limiting conditions. Both paediatricians and parents find benefit in preparing for such decisions. …
View article: Age at diagnosis and diagnostic delay across attention-deficit hyperactivity and autism spectrums
Age at diagnosis and diagnostic delay across attention-deficit hyperactivity and autism spectrums Open
Background: Despite the known benefits of accurate and timely diagnosis for children with attention-deficit hyperactivity disorder and autism spectrum disorders (autism), for some children this goal is not always achieved. Existing researc…
View article: Difficult toddler temperament – Prevalence and associated factors at 18-month follow-up of a birth cohort
Difficult toddler temperament – Prevalence and associated factors at 18-month follow-up of a birth cohort Open
Background A difficult temperament, when coupled with other risk factors, may lead to mental health problems in childhood, adolescence, and adulthood. The aim of this study was to investigate the prevalence of parental perception of diffic…
View article: Effectiveness of lifestyle interventions for improving the physical health of children and adolescents taking antipsychotic medications: protocol for a systematic review and meta-analysis
Effectiveness of lifestyle interventions for improving the physical health of children and adolescents taking antipsychotic medications: protocol for a systematic review and meta-analysis Open
Introduction Children and adolescents are increasingly prescribed antipsychotic medications off-label in the treatment of behavioural disorders. While antipsychotic medications are effective in managing behavioural issues, they carry a sig…
View article: Is Simulation as an Investigative Method as Good as Reality?
Is Simulation as an Investigative Method as Good as Reality? Open
Clinical simulation offers an alternative to naturalistic inquiry of phenomena in health care that are ethically and logistically difficult for researchers to access firsthand. However, whether it is a similar experience, and the extent si…
View article: P008 Pilot and Feasibility of Bright Light Therapy in Improving Sleep and Quality of Life in Children with Acute Lymphoblastic Leukaemia
P008 Pilot and Feasibility of Bright Light Therapy in Improving Sleep and Quality of Life in Children with Acute Lymphoblastic Leukaemia Open
Introduction Bright light therapy (BLT) improves sleep and quality of life (QOL) in adults with cancer and adolescents with mood disorders. Children with acute lymphoblastic leukaemia (ALL) are vulnerable to poor sleep, related to their ne…
View article: Developmental regression in children: Current and future directions
Developmental regression in children: Current and future directions Open
Developmental regression describes when a child loses previously established skills, such as the ability to speak words and is most recognised in neurodevelopmental conditions including Autism; Developmental Epileptic Encephalopathies, suc…
View article: Qualitative Study of Paediatric Advance Care Planning Through Simulation: How we did it and the Lessons Learned
Qualitative Study of Paediatric Advance Care Planning Through Simulation: How we did it and the Lessons Learned Open
Simulation is a well-established experiential educational tool in health care, which allows clinicians to learn and practise skills via a replication of reality. However, its use as a research tool is novel and emerging. As we designed a p…
View article: Prediction of obstructive sleep apnoea in children and adolescents with Down syndrome
Prediction of obstructive sleep apnoea in children and adolescents with Down syndrome Open
Background Obstructive sleep apnoea (OSA) is common in children and adolescents with Down syndrome (DS). Clinical guidelines recommend that all children with DS have polysomnography (PSG) for assessment of OSA by the age of 4 years, but ac…
View article: Acetylcholinesterase inhibitors for autistic spectrum disorders
Acetylcholinesterase inhibitors for autistic spectrum disorders Open
Evidence about the effectiveness of acetylcholinesterase inhibitors as a medication to improve outcomes for autistic adults is lacking, and for autistic children is very uncertain. There is a need for more evidence of improvement in outcom…
View article: The Australian evidence-based clinical practice guideline for attention deficit hyperactivity disorder
The Australian evidence-based clinical practice guideline for attention deficit hyperactivity disorder Open
Objective: The objective of this article was to provide an overview of the development and recommendations from the Australian evidence-based clinical practice guideline for attention deficit hyperactivity disorder (ADHD). The guideline ai…
View article: Addressing Child Mental Health Inequities Through Parental Mental Health and Preschool Attendance
Addressing Child Mental Health Inequities Through Parental Mental Health and Preschool Attendance Open
BACKGROUND Prevention is key to reducing socioeconomic inequities in children’s mental health problems, especially given limited availability and accessibility of services. We investigated the potential to reduce inequities for disadvantag…
View article: A prospective, longitudinal, case–control study to evaluate the neurodevelopment of children from birth to adolescence exposed to COVID-19 in utero
A prospective, longitudinal, case–control study to evaluate the neurodevelopment of children from birth to adolescence exposed to COVID-19 in utero Open
Background The Coronavirus disease (COVID-19) pandemic has created unprecedented acute global health challenges. However, it also presents a set of unquantified and poorly understood risks in the medium to long term, specifically, risks to…
View article: Is language ability associated with behaviors of concern in autism? A systematic review
Is language ability associated with behaviors of concern in autism? A systematic review Open
This review systematically synthesized evidence on the association between structural language ability and behaviors of concern (BoC) in autism. Four databases were searched for studies that included >10 autistic participants, measures of …