Janesh Gupta
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View article: Effect of pregnancy hormones on pain perception in the peripartum period: A narrative review
Effect of pregnancy hormones on pain perception in the peripartum period: A narrative review Open
Pregnancy is a period marked by significant hormonal fluctuations, which can influence pain perception. There are only a limited number of analgesic options that are considered safe for newborns and mothers. Understanding the impact of pre…
View article: Preventing recurrence of endometriosis-related pain by means of long-acting progestogen therapy: the PRE-EMPT RCT
Preventing recurrence of endometriosis-related pain by means of long-acting progestogen therapy: the PRE-EMPT RCT Open
Background Endometriosis affects 1 in 10 women, many of whom have surgery for persistent pain. Recurrence of symptoms following an operation is common. Although hormonal treatment can reduce this risk, there is uncertainty about the best o…
View article: Surgery and minimally invasive treatments for uterine fibroids
Surgery and minimally invasive treatments for uterine fibroids Open
This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To assess the effects of surgery and minimally invasive treatments for uterine fibroids.
View article: Diagnosis and management of endometrial hyperplasia: A UK national audit of adherence to national guidance 2012–2020
Diagnosis and management of endometrial hyperplasia: A UK national audit of adherence to national guidance 2012–2020 Open
Background Endometrial hyperplasia (EH) is a precusor lesion for endometrial cancer (EC), the commonest gynaecological malignancy in high-income countries. EH is a proliferation of glandular tissue, classified as either non-atypical endome…
View article: Rates of medical or surgical treatment for women with heavy menstrual bleeding: the ECLIPSE trial 10-year observational follow-up study
Rates of medical or surgical treatment for women with heavy menstrual bleeding: the ECLIPSE trial 10-year observational follow-up study Open
Background Heavy menstrual bleeding is a common problem that can significantly affect women’s lives until menopause. There is a lack of evidence on longer-term outcomes after seeking health care and treatment for heavy menstrual bleeding. …
View article: Prodigy Long-Established Solution in Degenerative Musculoskeletal Disease as Vishwachi with Special Reference to Cervical Spondylosis - A Novel Case Report
Prodigy Long-Established Solution in Degenerative Musculoskeletal Disease as Vishwachi with Special Reference to Cervical Spondylosis - A Novel Case Report Open
A rectifier that is a unique merger of the two utterly non-identical therapeutic procedures, namely Viddhakarma (piercing) and Agnikarma(thermal cauterization), collectively termed "Viddhagnikarma." It is a modification of the concept by t…
View article: An Extracellular/Membrane-Bound S100P Pool Regulates Motility and Invasion of Human Extravillous Trophoblast Lines and Primary Cells
An Extracellular/Membrane-Bound S100P Pool Regulates Motility and Invasion of Human Extravillous Trophoblast Lines and Primary Cells Open
Whilst S100P has been shown to be a marker for carcinogenesis, we have shown, in non-physio-pathological states, that its expression promotes trophoblast motility and invasion but the mechanisms explaining these cellular processes are unkn…
View article: Improving trustworthiness in research in women's health: A collective effort by OBGYN Editors
Improving trustworthiness in research in women's health: A collective effort by OBGYN Editors Open
status: Published
View article: Improving trustworthiness in research in women's health: A collective effort by OBGYN Editors
Improving trustworthiness in research in women's health: A collective effort by OBGYN Editors Open
Overall, more than 1.7 million entries were added to PubMed in 2022. Over 35 000 Obstetrics articles alone have been added per year since 2020, with that number reaching over 40 000 in 2021 and 2022.1 As the volume of published medical res…
View article: Improving trustworthiness in research in women's health: A collective effort by OBGYN editors
Improving trustworthiness in research in women's health: A collective effort by OBGYN editors Open
Overall, more than 1.7 million entries were added to PubMed in 2022. Over 35 000 Obstetrics articles alone have been added per year since 2020, with that number reaching over 40 000 in 2021 and 2022.1 As the volume of published medical res…
View article: Lymphedema Praecox a subtle exigent case study through endogenic avenue W.S.R. to Urustambha
Lymphedema Praecox a subtle exigent case study through endogenic avenue W.S.R. to Urustambha Open
The lymphatic system has historically been disregarded, undervalued, and poorly understood. As it mimics chronic venous insufficiency, it leaves patients in a terrible condition. One such congenital condition where aberrant protein-rich fl…
View article: Ezrin and Its Phosphorylated Thr567 form Are Key Regulators of Human Extravillous Trophoblast Motility and Invasion
Ezrin and Its Phosphorylated Thr567 form Are Key Regulators of Human Extravillous Trophoblast Motility and Invasion Open
The protein ezrin has been shown to enhance cancer cell motility and invasion leading to malignant behaviours in solid tumours, but a similar regulatory function in the early physiological reproduction state is, however, much less clear. W…
View article: Medical treatment for heavy menstrual bleeding in primary care: 10-year data from the ECLIPSE trial
Medical treatment for heavy menstrual bleeding in primary care: 10-year data from the ECLIPSE trial Open
Background Heavy menstrual bleeding (HMB) is a common problem that can significantly affect women’s lives. There is a lack of evidence on long-term outcomes after seeking treatment. Aim To assess continuation rates of medical treatments an…
View article: Synthetic osmotic dilators (Dilapan-S) or dinoprostone vaginal inserts (Propess) for inpatient induction of labour: A UK cost-consequence model
Synthetic osmotic dilators (Dilapan-S) or dinoprostone vaginal inserts (Propess) for inpatient induction of labour: A UK cost-consequence model Open
The model indicates that adoption of Dilapan-S is likely to be cost-neutral and reduce staff workload in comparison to Propess. Results require support from real-world data and further exploration of Dilapan-S is to be encouraged.
View article: Trophoblast uptake of DBP regulates intracellular actin and promotes matrix invasion
Trophoblast uptake of DBP regulates intracellular actin and promotes matrix invasion Open
Early pregnancy is characterised by elevated circulating levels of vitamin D binding protein (DBP). The impact of this on maternal and fetal health is unclear but DBP is present in the placenta, and DBP gene variants have been linked to ma…
View article: The INTEGRITY Trial: Preservation of Uterine-Wall Integrity 12 Months After Transcervical Fibroid Ablation with the Sonata System
The INTEGRITY Trial: Preservation of Uterine-Wall Integrity 12 Months After Transcervical Fibroid Ablation with the Sonata System Open
Objective: The aim of this research was to evaluate uterine-wall integrity 12 months after transcervical fibroid ablation (TFA) of uterine fibroids with the Sonata® system (Gynesonics Inc., Redwood City, CA). Materials and Methods: INTEGRI…
View article: An overview of the past, current and future trends for cervical ripening in induction of labour
An overview of the past, current and future trends for cervical ripening in induction of labour Open
Key content The advantages and disadvantages of pharmacological methods and mechanical methods (such as the osmotic cervical dilator Dilapan‐S ® and Foley catheter) for labour induction are discussed. This article looks at the internationa…
View article: Position in the second stage of labour for women without epidural anaesthesia
Position in the second stage of labour for women without epidural anaesthesia Open
The findings of this review suggest several possible benefits for upright posture in women without epidural anaesthesia, such as a very small reduction in the duration of second stage of labour (mainly from the primigravid group), reductio…