Explanipedia

Electric Acupuncture Mimics Exercise to Promote Myogenesis, Angiogenesis and Neurogenesis Open

Zhen Su, Manshu Yu, Ying Huang, Janet D. Klein, Shuyang Bian , et al. · 2024

Our previous study demonstrated that acupuncture with low frequency electrical stimulation (Acu-LFES) attenuates skeletal muscle atrophy by improving muscle progenitor cell regeneration. The present study examines whether Acu-LFES improves…

Aldosterone Contributes to Vasopressin Escape through Changes in Water and Urea Transport Open

Yanhua Wang, Lauren M. LaRocque, Joseph A. Ruiz, Eva L. Rodriguez, Jeff M. Sands , et al. · 2023

Hyponatremia (hypo-osmolality) is a disorder of water homeostasis due to abnormal renal diluting capacity. The body limits the degree to which serum sodium concentration falls through a mechanism called “vasopressin escape”. Vasopressin es…

Phosphatases Decrease Water and Urea Permeability in Rat Inner Medullary Collecting Ducts Open

Yanhua Wang, Janet D. Klein, Jeff M. Sands · 2023

We previously showed that the phosphatases PP1/PP2A and PP2B dephosphorylate the water channel, AQP2, suggesting their role in water reabsorption. In this study, we investigated whether protein phosphatase 2A (PP2A) and protein phosphatase…

The impact of senescence on muscle wasting in chronic kidney disease Open

Ying Huang, Bin Wang, Faten Hassounah, S. Russ Price, Janet D. Klein , et al. · 2022

Background Muscle wasting is a common complication of chronic kidney disease (CKD) that is associated with higher mortality. Although the mechanisms of myofibre loss in CKD has been widely studied, the contribution of muscle precursor cell…

Effects of home-based leg heat therapy on walking performance in patients with symptomatic peripheral artery disease: a pilot randomized trial Open

Jacob C. Monroe, Byung Joon Pae, Christopher K. Kargl, Timothy P. Gavin, Jason G. Parker , et al. · 2022

This is the first sham-controlled trial to examine the effects of home-based leg heat therapy (HT) on walking performance in patients with peripheral artery disease (PAD). We demonstrate that unsupervised HT using water-circulating trouser…

Downregulation of let-7 by Electrical Acupuncture Increases Protein Synthesis in Mice Open

Ying Huang, Manshu Yu, Akihiro Kuma, Janet D. Klein, Yanhua Wang , et al. · 2021

Background Our previous study found that acupuncture with low frequency electrical stimulation (Acu/LFES) prevents muscle atrophy by attenuation of protein degradation in mice. The current study examines the impact of Acu/LFES on protein s…

An AMPK activator as a therapeutic option for congenital nephrogenic diabetes insipidus Open

Janet D. Klein, Ish Khanna, Ram Pillarisetti, Rachael A. Hagan, Lauren M. LaRocque , et al. · 2021

Nephrogenic diabetes insipidus (NDI) patients produce large amounts of dilute urine. NDI can be congenital, resulting from mutations in the type-2 vasopressin receptor (V2R), or acquired, resulting from medications such as lithium. There a…

Adaptive physiological water conservation explains hypertension and muscle catabolism in experimental chronic renal failure Open

J Kovarík, Norihiko Morisawa, Johannes Wild, Adriana Marton, Kaoru Takase‐Minegishi , et al. · 2021

Aim We have reported earlier that a high salt intake triggered an aestivation ‐like natriuretic‐ureotelic body water conservation response that lowered muscle mass and increased blood pressure. Here, we tested the hypothesis that a similar…

Adrenomedullin Inhibits Osmotic Water Permeability in Rat Inner Medullary Collecting Ducts Open

Fuying Ma, Guangping Chen, Eva L. Rodriguez, Janet D. Klein, Jeff M. Sands , et al. · 2020

Adrenomedullin (ADM) is a vasodilator that causes natriuresis and diuresis. However, the direct effect of ADM on osmotic water permeability in the rat inner medullary collecting duct (IMCD) has not been tested. We investigated whether ADM …

14-3-3γ, a novel regulator of the large-conductance Ca2+-activated K+ channel Open

Shan Chen, Xiuyan Feng, Xinxin Chen, Zhizhi Zhuang, Jia Xiao , et al. · 2020

14-3-3γ is a small protein regulating its target proteins through binding to phosphorylated serine/threonine residues. Sequence analysis of large-conductance Ca 2+ -activated K + (BK) channels revealed a putative 14-3-3 binding site in the…

Inhibition of urea transporter ameliorates uremic cardiomyopathy in chronic kidney disease Open

Akihiro Kuma, Xiaonan H. Wang, Janet D. Klein, Lin Tan, Nawazish Naqvi , et al. · 2020

Uremic cardiomyopathy, characterized by hypertension, cardiac hypertrophy, and fibrosis, is a complication of chronic kidney disease (CKD). Urea transporter (UT) inhibition increases the excretion of water and urea, but the effect on uremi…

Aldosterone Decreases Vasopressin-Stimulated Water Reabsorption in Rat Inner Medullary Collecting Ducts Open

Yanhua Wang, Fuying Ma, Eva L. Rodriguez, Janet D. Klein, Jeff M. Sands · 2020

Aldosterone indirectly regulates water reabsorption in the distal tubule by regulating sodium reabsorption. However, the direct effect of aldosterone on vasopressin-regulated water and urea permeability in the rat inner medullary collectin…

UT-A1/A3 knockout mice show reduced fibrosis following unilateral ureteral obstruction Open

Fitra Rianto, Akihiro Kuma, Carla L. Ellis, Faten Hassounah, Eva L. Rodriguez , et al. · 2020

Renal fibrosis is a major contributor to the development and progression of chronic kidney disease. A low-protein diet can reduce the progression of chronic kidney disease and reduce the development of renal fibrosis, although the mechanis…

Exogenous miR-29a Attenuates Muscle Atrophy and Kidney Fibrosis in Unilateral Ureteral Obstruction Mice Open

Bin Wang, Juan Wang, Wei He, Yajie Zhao, Aiqing Zhang , et al. · 2020

Renal fibrosis leads to end-stage renal disease, but antifibrotic drugs are difficult to develop. Chronic kidney disease often results in muscle wasting, and thereby increases morbidity and mortality. In this work, adeno-associated virus (…

Electrical acupuncture increases protein synthesis through downregulation of let-7 Open

Zhen Su, Manshu Yu, Akihiro Kuma, Faten Hassounah, Fuying Ma , et al. · 2020

The authors have requested that this preprint be removed from Research Square.

Aestivation Motifs Explain Hypertension and Muscle Catabolism in Experimental Chronic Renal Failure Open

J Kovarík, Norihiko Morisawa, Johannes Wild, Adriana Marton, Kaoru Takase-Minegishi , et al. · 2020

Exogenous miR‐26a suppresses muscle wasting and renal fibrosis in obstructive kidney disease Open

Aiqing Zhang, Haidong Wang, Bin Wang, Yanggang Yuan, Janet D. Klein , et al. · 2019

Kidney fibrosis occurs in almost every type of chronic kidney disease. We found that microRNA (miR)‐26a was decreased in the kidney, muscle, and exosomes of unilateral ureteral obstruction (UUO) mice. We hypothesized that exogenous miR‐26 …

High glucose reduces expression of podocin in cultured human podocytes by stimulating TRPC6 Open

Xiaoyu Lu, Bingchen Liu, Yuze Cao, Chang Eun Song, Hua Su , et al. · 2019

The transient receptor potential canonical 6 (TRPC6) channel and podocin are colocalized in the glomerular slit diaphragm as an important complex to maintain podocyte function. Gain of TRPC6 function and loss of podocin function induce pod…

SUN-281 Electrically stimulated acupuncture improve muscle function and increases renal blood flow through exosomes-carried miR-181 Open

Z. su, Janet D. Klein · 2019

our previous study found that acupuncture with low frequency electrical stimulation (Acu/LFES) can prevent muscle atrophy by increasing muscle protein anabolism in mouse models of chronic kidney disease and diabetes. Previous other studies…

Exosome-Mediated miR-29 Transfer Reduces Muscle Atrophy and Kidney Fibrosis in Mice Open

Haidong Wang, Bin Wang, Aiqing Zhang, Faten Hassounah, Yiqi Seow , et al. · 2019

Our previous study showed that miR-29 attenuates muscle wasting in chronic kidney disease. Other studies found that miR-29 has anti-fibrosis activity. We hypothesized that intramuscular injection of exosome-encapsulated miR-29 would counte…

miR-26a Limits Muscle Wasting and Cardiac Fibrosis through Exosome-Mediated microRNA Transfer in Chronic Kidney Disease Open

Bin Wang, Aiqing Zhang, Haidong Wang, Janet D. Klein, Lin Tan , et al. · 2019

Uremic cardiomyopathy and muscle atrophy are associated with insulin resistance and contribute to chronic kidney disease (CKD)-induced morbidity and mortality. We hypothesized that restoration of miR-26a levels would enhance exosome…

Exogenous miR-29a Attenuates Muscle Atrophy and Kidney Fibrosis in UUO Mice Open

Bin Wang, Juan Wang, Wei He, Yaje Zhao, Aiqing Zhang , et al. · 2019

GDE5 inhibition accumulates intracellular glycerophosphocholine and suppresses adipogenesis at a mitotic clonal expansion stage Open

Yuri Okazaki, Keishi Nakamura, Shuto Takeda, Ikumi Yoshizawa, Fumiyo Yoshida , et al. · 2018

Mammalian glycerophosphodiesterases (GDEs) were recently shown to be involved in multiple cellular signaling pathways. This study showed that decreased GDE5 expression results in accumulation of intracellular glycerophosphocholine (GPC), s…

Glucagon infusion alters the hyperpolarized 13C‐urea renal hemodynamic signature Open

Haiyun Qi, Christian Østergaard Mariager, Per Mose Nielsen, Marie Schroeder, Jakob Lindhardt , et al. · 2018

Renal urea handling is central to the urine concentrating mechanism, and as such the ability to image urea transport in the kidney is an important potential imaging biomarker for renal functional assessment. Glucagon levels associated with…

Hyperglycemia promotes microvillus membrane expression of DMT1 in intestinal epithelial cells in a PKCα‐dependent manner Open

Luqing Zhao, Thomas B. Bartnikas, Xiangpeng Chu, Janet D. Klein, C. Chris Yun , et al. · 2018

Excessive iron increases the incidence of diabetes and worsens diabetic complications. Reciprocally, diabetes induces iron loading, partially attributable to elevated intestinal iron export according to a recent report. Herein, we show tha…

Electrically stimulated acupuncture increases renal blood flow through exosome-carried miR-181 Open

Janet D. Klein, Xiaonan H. Wang · 2018

Acupuncture with low-frequency electrical stimulation (Acu/LFES) can prevent muscle atrophy by increasing muscle protein anabolism in mouse models of chronic kidney disease. During the treatment of muscle wasting, we found that Acu/LFES on…

The Role of Intercalated Cell Nedd4–2 in BP Regulation, Ion Transport, and Transporter Expression Open

Masayoshi Nanami, Truyen D. Pham, Young Hee Kim, Baoli Yang, Roy L. Sutliff , et al. · 2018

Background Nedd4–2 is an E3 ubiquitin-protein ligase that associates with transport proteins, causing their ubiquitylation, and then internalization and degradation. Previous research has suggested a correlation between Nedd4–2 and BP. In …

miRNA‐23a/27a attenuates muscle atrophy and renal fibrosis through muscle‐kidney crosstalk Open

Aiqing Zhang, Min Li, Bin Wang, Janet D. Klein, S. Russ Price , et al. · 2018

Background The treatment of muscle wasting is accompanied by benefits in other organs, possibly resulting from muscle–organ crosstalk. However, how the muscle communicates with these organs is less understood. Two microRNAs (miRs), miR‐23a…

Increased glucocorticoid hormone actions induce skin-specific Na+ and water loss in melanocortin 3 receptor knockout mice Open

Kento Kitada, Xiaoyan Zhang, Janet D. Klein, Adriana Marton, Steffen Daub , et al. · 2018

Backgrounds: We recently reported that the body differentially controls its body fluid content by natriuretic-ureotelic regulation, which is characterized by a balance between aldosterone/Na+-driven or glucocorticoid/urea-driven water reab…

Increased glucocorticoid hormone actions induce skin-specific Na+ and water loss in melanocortin 3 receptor knockout mice Open

Kento Kitada, Xiaoyan Zhang, Janet D. Klein, Adriana Marton, Steffen Daub , et al. · 2018

Backgrounds: We recently reported that the body differentially controls its body fluid content by natriuretic-ureotelic regulation, which is characterized by a balance between aldosterone/Na+-driven or glucocorticoid/urea-driven water reab…

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