Janet L. Pitman
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View article: Correction: Sczelecki, S.; Pitman, J.L. The Validation of a Precursor Lesion of Epithelial Ovarian Cancer in Fancd2-KO Mice. Cancers 2023, 15, 2595
Correction: Sczelecki, S.; Pitman, J.L. The Validation of a Precursor Lesion of Epithelial Ovarian Cancer in Fancd2-KO Mice. Cancers 2023, 15, 2595 Open
There was an error in the original publication [...]
View article: A novel antibody treatment reduces deformed wing virus loads in the western honey bee ( <i>Apis mellifera</i> )
A novel antibody treatment reduces deformed wing virus loads in the western honey bee ( <i>Apis mellifera</i> ) Open
The deformed wing virus ( Iflavirus aladeformis ) (DWV) is a key driver of colony loss in the western honey bee ( Apis mellifera ). Here, we demonstrate that orally delivered anti-DWV antibodies can act systemically to reduce DWV loads in …
View article: Molecular forms of BMP15 and GDF9 in mammalian species that differ in litter size
Molecular forms of BMP15 and GDF9 in mammalian species that differ in litter size Open
View article: The Validation of a Precursor Lesion of Epithelial Ovarian Cancer in Fancd2-KO Mice
The Validation of a Precursor Lesion of Epithelial Ovarian Cancer in Fancd2-KO Mice Open
Ovarian cancer (OC) has the highest mortality rate of all gynaecological malignancies. The asymptomatic nature and limited understanding of early disease hamper research into early-stage OC. Therefore, there is an urgent need for models of…
View article: CCDC 2191714: Experimental Crystal Structure Determination
CCDC 2191714: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2191715: Experimental Crystal Structure Determination
CCDC 2191715: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2191713: Experimental Crystal Structure Determination
CCDC 2191713: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: The discovery of 12β-methyl-17-epi-18-nor-bile acids as potent and selective TGR5 agonists
The discovery of 12β-methyl-17-epi-18-nor-bile acids as potent and selective TGR5 agonists Open
View article: A comparison between oestradiol aptamers as receptors in CNT FET biosensors
A comparison between oestradiol aptamers as receptors in CNT FET biosensors Open
Two oestradiol aptamers as receptors on carbon nanotube sensors are compared. We show differences in sensor behaviour between the aptamers that are not explained by published KD values, which aid in understanding and optimising these senso…
View article: Validation of a molecular assay to detect SARS-CoV-2 in saliva
Validation of a molecular assay to detect SARS-CoV-2 in saliva Open
AIM: To validate a reverse transcriptase-quantitative polymerase chain reaction (RT-qPCR) assay to detect SARS-CoV-2 in saliva in two independent Aotearoa New Zealand laboratories. METHODS: An RT-qPCR assay developed at University of Illin…
View article: CCDC 2115801: Experimental Crystal Structure Determination
CCDC 2115801: Experimental Crystal Structure Determination Open
View article: CCDC 2115802: Experimental Crystal Structure Determination
CCDC 2115802: Experimental Crystal Structure Determination Open
View article: CCDC 2115803: Experimental Crystal Structure Determination
CCDC 2115803: Experimental Crystal Structure Determination Open
View article: CCDC 2115800: Experimental Crystal Structure Determination
CCDC 2115800: Experimental Crystal Structure Determination Open
View article: CCDC 2115804: Experimental Crystal Structure Determination
CCDC 2115804: Experimental Crystal Structure Determination Open
View article: CCDC 2115798: Experimental Crystal Structure Determination
CCDC 2115798: Experimental Crystal Structure Determination Open
View article: CCDC 2115799: Experimental Crystal Structure Determination
CCDC 2115799: Experimental Crystal Structure Determination Open
View article: Synthesis of 12β-methyl-18-<i>nor</i>-avicholic acid analogues as potential TGR5 agonists
Synthesis of 12β-methyl-18-<i>nor</i>-avicholic acid analogues as potential TGR5 agonists Open
A series of 12β-methyl-18- nor -avicholic acid analogues was prepared and evaluated for activity at TGR5 and FXR. Compounds 46 and 53 emerged as low-micromolar TGR5 agonists, providing potential new templates for further development.
View article: The microenvironment of ovarian follicles in fertile dairy cows is associated with high oocyte quality
The microenvironment of ovarian follicles in fertile dairy cows is associated with high oocyte quality Open
View article: The ovarian follicle of ruminants: the path from conceptus to adult
The ovarian follicle of ruminants: the path from conceptus to adult Open
This review resulted from an international workshop and presents a consensus view of critical advances over the past decade in our understanding of follicle function in ruminants. The major concepts covered include: (1) the value of major …
View article: The follicular microenvironment in low (++) and high (I+B+) ovulation rate ewes
The follicular microenvironment in low (++) and high (I+B+) ovulation rate ewes Open
Ewes with single copy mutations in GDF9 , BMP15 or BMPR1B have smaller preovulatory follicles containing fewer granulosa cells (GC), while developmental competency of the oocyte appears to be maintained. We hypothesised that similarities a…
View article: Molecular forms of ruminant BMP15 and GDF9 and putative interactions with receptors
Molecular forms of ruminant BMP15 and GDF9 and putative interactions with receptors Open
Bone morphogenetic factor 15 (BMP15) and growth differentiation factor 9 (GDF9) are oocyte-secreted factors with demonstrable effects on ovarian follicular development and ovulation rate. However, the molecular forms of BMP15 and GDF9 prod…
View article: Ovarian characteristics in sheep with multiple fecundity genes
Ovarian characteristics in sheep with multiple fecundity genes Open
Ewes heterozygous for combinations of the Inverdale (FecX I ; I+), Booroola (FecB; B+) and Woodlands (FecX2 W ; W+) mutations have ovulation rates higher than each mutation separately. The aims of the experiments described herein were to e…