Janet Newman
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View article: Structural insights into the enzymatic breakdown of azomycin-derived antibiotics by 2-nitroimdazole hydrolase (NnhA)
Structural insights into the enzymatic breakdown of azomycin-derived antibiotics by 2-nitroimdazole hydrolase (NnhA) Open
View article: Vγ9Vδ2 T cells recognize butyrophilin 2A1 and 3A1 heteromers
Vγ9Vδ2 T cells recognize butyrophilin 2A1 and 3A1 heteromers Open
View article: Enhancing PET Degrading Enzymes: A Combinatory Approach
Enhancing PET Degrading Enzymes: A Combinatory Approach Open
Plastic waste has become a substantial environmental issue. A potential strategy to mitigate this problem is to use enzymatic hydrolysis of plastics to depolymerize post‐consumer waste and allow it to be reused. Over the last few decades, …
View article: Characterization of novel mevalonate kinases from the tardigrade <i>Ramazzottius varieornatus</i> and the psychrophilic archaeon <i>Methanococcoides burtonii</i>
Characterization of novel mevalonate kinases from the tardigrade <i>Ramazzottius varieornatus</i> and the psychrophilic archaeon <i>Methanococcoides burtonii</i> Open
Mevalonate kinase is central to the isoprenoid biosynthesis pathway. Here, high-resolution X-ray crystal structures of two mevalonate kinases are presented: a eukaryotic protein from Ramazzottius varieornatus and an archaeal protein from M…
View article: Discovery of a highly potent, selective, orally bioavailable inhibitor of KAT6A/B histone acetyltransferases with efficacy against KAT6A-high ER+ breast cancer
Discovery of a highly potent, selective, orally bioavailable inhibitor of KAT6A/B histone acetyltransferases with efficacy against KAT6A-high ER+ breast cancer Open
View article: Data from A Human Monoclonal Antibody against Insulin-Like Growth Factor-II Blocks the Growth of Human Hepatocellular Carcinoma Cell Lines <i>In vitro</i> and <i>In vivo</i>
Data from A Human Monoclonal Antibody against Insulin-Like Growth Factor-II Blocks the Growth of Human Hepatocellular Carcinoma Cell Lines <i>In vitro</i> and <i>In vivo</i> Open
Elevated expression of insulin-like growth factor-II (IGF-II) is frequently observed in a variety of human malignancies, including breast, colon, and liver cancer. As IGF-II can deliver a mitogenic signal through both IGF-IR and an alterna…
View article: Supplementary Table from A Human Monoclonal Antibody against Insulin-Like Growth Factor-II Blocks the Growth of Human Hepatocellular Carcinoma Cell Lines <i>In vitro</i> and <i>In vivo</i>
Supplementary Table from A Human Monoclonal Antibody against Insulin-Like Growth Factor-II Blocks the Growth of Human Hepatocellular Carcinoma Cell Lines <i>In vitro</i> and <i>In vivo</i> Open
Supplementary Table from A Human Monoclonal Antibody against Insulin-Like Growth Factor-II Blocks the Growth of Human Hepatocellular Carcinoma Cell Lines In vitro and In vivo
View article: Data from A Human Monoclonal Antibody against Insulin-Like Growth Factor-II Blocks the Growth of Human Hepatocellular Carcinoma Cell Lines <i>In vitro</i> and <i>In vivo</i>
Data from A Human Monoclonal Antibody against Insulin-Like Growth Factor-II Blocks the Growth of Human Hepatocellular Carcinoma Cell Lines <i>In vitro</i> and <i>In vivo</i> Open
Elevated expression of insulin-like growth factor-II (IGF-II) is frequently observed in a variety of human malignancies, including breast, colon, and liver cancer. As IGF-II can deliver a mitogenic signal through both IGF-IR and an alterna…
View article: Supplementary Table from A Human Monoclonal Antibody against Insulin-Like Growth Factor-II Blocks the Growth of Human Hepatocellular Carcinoma Cell Lines <i>In vitro</i> and <i>In vivo</i>
Supplementary Table from A Human Monoclonal Antibody against Insulin-Like Growth Factor-II Blocks the Growth of Human Hepatocellular Carcinoma Cell Lines <i>In vitro</i> and <i>In vivo</i> Open
Supplementary Table from A Human Monoclonal Antibody against Insulin-Like Growth Factor-II Blocks the Growth of Human Hepatocellular Carcinoma Cell Lines In vitro and In vivo
View article: Moving beyond MARCO
Moving beyond MARCO Open
The use of imaging systems in protein crystallisation means that the experimental setups no longer require manual inspection to determine the outcome of the trials. However, it leads to the problem of how best to find images which contain …
View article: Moving beyond MARCO
Moving beyond MARCO Open
The use of imaging systems in protein crystallisation means that the experimental setups no longer require manual inspection to determine the outcome of the trials. However, it leads to the problem of how best to find images which contain …
View article: Molecular characterization of cyanobacterial short‐chain prenyltransferases and discovery of a novel <scp>GGPP</scp> phosphatase
Molecular characterization of cyanobacterial short‐chain prenyltransferases and discovery of a novel <span>GGPP</span> phosphatase Open
Cyanobacteria are photosynthetic prokaryotes with strong potential to be used for industrial terpenoid production. However, the key enzymes forming the principal terpenoid building blocks, called short‐chain prenyltransferases (SPTs), are …
View article: Insights Into Drug Repurposing, as Well as Specificity and Compound Properties of Piperidine-Based SARS-CoV-2 PLpro Inhibitors
Insights Into Drug Repurposing, as Well as Specificity and Compound Properties of Piperidine-Based SARS-CoV-2 PLpro Inhibitors Open
The COVID-19 pandemic continues unabated, emphasizing the need for additional antiviral treatment options to prevent hospitalization and death of patients infected with SARS-CoV-2. The papain-like protease (PLpro) domain is part of the SAR…
View article: Design of a methotrexate-controlled chemical dimerization system and its use in bio-electronic devices
Design of a methotrexate-controlled chemical dimerization system and its use in bio-electronic devices Open
Natural evolution produced polypeptides that selectively recognize chemical entities and their polymers, ranging from ions to proteins and nucleic acids. Such selective interactions serve as entry points to biological signaling and metabol…
View article: Submission of structural biology data for review purposes
Submission of structural biology data for review purposes Open
The editors discuss the submission of structural biology data.
View article: Topical Reviews in <i>Acta Crystallographica F Structural Biology Communications</i>
Topical Reviews in <i>Acta Crystallographica F Structural Biology Communications</i> Open
Editors of Acta Cryst. F Structural Biology Communications discuss their plans for topical reviews.
View article: Data and Diversity Driven Development of a Shotgun Crystallisation Screen using the Protein Data Bank
Data and Diversity Driven Development of a Shotgun Crystallisation Screen using the Protein Data Bank Open
Protein crystallisation has for decades been a critical and restrictive step in macro-molecular structure determination via X-ray diffraction. Crystallisation typically involves a multi-stage exploration of the available chemical space, be…
View article: Data- and diversity-driven development of a <i>Shotgun</i> crystallisation screen using the Protein Data Bank
Data- and diversity-driven development of a <i>Shotgun</i> crystallisation screen using the Protein Data Bank Open
Protein crystallisation has for decades been a critical and restrictive step in macro-molecular structure determination via X-ray diffraction. Crystallisation typically involves a multi-stage exploration of the available chemical space, be…
View article: C3 Protein Crystallization Dataset
C3 Protein Crystallization Dataset Open
Data-set containing labelled images from crystallization experiments Has both visible light images and UV images. Each image pair is from an unique experiment. Corresponding numbers in the vis and uv datasets are from the same experiment. …
View article: C3 Protein Crystallization Dataset
C3 Protein Crystallization Dataset Open
Data-set containing labelled images from crystallization experiments Has both visible light images and UV images. Each image pair is from an unique experiment. Corresponding numbers in the vis and uv datasets are from the same experiment. …
View article: Structure-guided selection of puromycin N-acetyltransferase mutants with enhanced selection stringency for deriving mammalian cell lines expressing recombinant proteins
Structure-guided selection of puromycin N-acetyltransferase mutants with enhanced selection stringency for deriving mammalian cell lines expressing recombinant proteins Open
View article: The X-ray crystal structure of the N-terminal domain of Ssr4, a <i>Schizosaccharomyces pombe</i> chromatin-remodelling protein
The X-ray crystal structure of the N-terminal domain of Ssr4, a <i>Schizosaccharomyces pombe</i> chromatin-remodelling protein Open
Ssr4 is a yeast protein from Schizosaccharomyces pombe and is an essential part of the chromatin-remodelling [SWI/SNF and RSC (remodelling the structure of chromatin)] complexes found in S. pombe . These complexes (or their homologues) reg…
View article: Contamination or serendipity – doing the wrong thing by chance
Contamination or serendipity – doing the wrong thing by chance Open
To contaminate – definition 2 in the Merriam-Webster (online) dictionary – is to ‘make unfit for use by the introduction of unwholesome or undesirable elements’, and a contaminant is then something that contaminates. As was pointed out in …
View article: Mechanism and inhibition of the papain‐like protease, PLpro, of SARS‐CoV‐2
Mechanism and inhibition of the papain‐like protease, PLpro, of SARS‐CoV‐2 Open
View article: Crystal structures of human ENPP1 in apo and bound forms
Crystal structures of human ENPP1 in apo and bound forms Open
Cancer is one of the leading causes of mortality in humans, and recent work has focused on the area of immuno-oncology, in which the immune system is used to specifically target cancerous cells. Ectonucleotide pyrophosphatase/phosphodieste…
View article: Innovation versus practice in biological crystallization
Innovation versus practice in biological crystallization Open
Edward Snell, of the Hauptmann Woodward Institute in Buffalo, NY has a great introduction to his talks on crystallization Without crystals, there is no crystallography – without crystallography, there are no crystallographers. This succinc…
View article: Mechanism and inhibition of SARS-CoV-2 PLpro
Mechanism and inhibition of SARS-CoV-2 PLpro Open
Coronaviruses, including SARS-CoV-2, encode multifunctional proteases that are essential for viral replication and evasion of host innate immune mechanisms. The papain-like protease PLpro cleaves the viral polyprotein, and reverses inflamm…
View article: Predicting the Effect of Chemical Factors on the pH of Crystallization Trials
Predicting the Effect of Chemical Factors on the pH of Crystallization Trials Open
View article: Tools to Ease the Choice and Design of Protein Crystallisation Experiments
Tools to Ease the Choice and Design of Protein Crystallisation Experiments Open
The process of macromolecular crystallisation almost always begins by setting up crystallisation trials using commercial or other premade screens, followed by cycles of optimisation where the crystallisation cocktails are focused towards a…
View article: Predicting the Effect of Chemical Factors on the pH of Crystallisation Trials
Predicting the Effect of Chemical Factors on the pH of Crystallisation Trials Open