Explanipedia

RBIO-10. Targeting telomere maintenance sensitizes group 3 medulloblastomas to ionizing radiation Open

Jangham Jung, Bohyeon Yu, Emanuele Filiberto Rosatti, J Costello, Marco Gallus , et al. · 2025

Ionizing radiation (IR) is part of standard care for group 3 (G3) medulloblastomas (MBs), the most aggressive molecular subtype of the most common malignant pediatric brain cancer. However, IR is often not curative and causes debilitating …

STEM-18. GENETIC LINEAGE TRACING OF MEDULLOBLASTOMA UNDER THERAPY WITH SPATIAL CONTEXT Open

Bohyeon Yu, Jangham Jung, Abhinav Jain, Emanuele Filiberto Rosatti, Joanna J. Phillips , et al. · 2025

Recent single-cell studies implicate the glutamatergic lineage of the rhombic lip (RL) as the origin of group (G) 3/4 medulloblastomas (MBs) and a stalled differentiation program as underlying their malignant transformation. It is unknown,…

Developmental Plasticity and Stromal Co-option Shape a Pituitary Neuroendocrine Tumor Transcriptional Continuum Open

Robert C. Osorio, Jun Yeop Oh, Jangham Jung, Alexander J. Ehrenberg, Atul Saha , et al. · 2025

Pituitary neuroendocrine tumors (PitNETs) are common intracranial neoplasms with complex biology underpinned by unresolved cellular origins, molecular heterogeneity, and microenvironment interactions. Here, we employ single-nuclei RNA-sequ…

Tumour-wide RNA splicing aberrations generate actionable public neoantigens Open

Darwin Kwok, Nicholas Stevers, Iñaki Etxeberría, Takahide Nejo, Maggie Colton Cove , et al. · 2025

T cell-based immunotherapies hold promise in treating cancer by leveraging the immune system’s recognition of cancer-specific antigens 1 . However, their efficacy is limited in tumours with few somatic mutations and substantial intratumour…

154 Tumor-wide RNA splicing aberrations generate immunogenic public neoantigens across various cancer types Open

Darwin Kwok, Nicholas Stevers, Iñaki Etxeberría, Takahide Nejo, Maggie Colton Cove , et al. · 2024

155 Sub-clonal antigenic heterogeneity mediates immune evasion in low-grade gliomas Open

Darwin Kwok, Michael Zhang, Cliff Wang, Maggie Colton Cove, Nicholas Stevers , et al. · 2024

TRLS-11. PNOC005: ONCOLYTIC MEASLES VIRUS FOR THE TREATMENT OF CHILDREN AND YOUNG ADULTS WITH RECURRENT MEDULLOBLASTOMA OR ATYPICAL TERATOID RHABDOID TUMOR Open

Cassie Kline, Bohyeon Yu, Truman Knowles, Aeesha Ranavaya, Jane E. Minturn , et al. · 2024

BACKGROUND PNOC005 is a phase 1 clinical trial investigating the safety and tolerability of intratumoral or intrathecal administration of oncolytic measles virus (MV-NIS) in children and young adults with recurrent medulloblastoma (MB) or …

Tumor-wide RNA splicing aberrations generate immunogenic public neoantigens Open

Hideho Okada, Darwin Kwok, Nicholas Stevers, Takahide Nejo, Lee Chen , et al. · 2023

T-cell-based immunotherapies hold promise in treating cancer by leveraging the immune system’s recognition of cancer-specific antigens. 1 However, their efficacy is often limited in tumors with fewer somatic mutations and significant intra…

IMMU-16. PUBLIC TUMOR-WIDE NEOANTIGENS DERIVED FROM CLONAL ABERRANT SPLICING EVENTS DRIVE TUMOR-SPECIFIC T-CELL RESPONSES Open

Darwin Kwok, Nicholas Stevers, Takahide Nejo, Jangham Jung, Lee Chen , et al. · 2023

BACKGROUND Immunotherapy in gliomas is limited by tumor heterogeneity and low mutational burden. We developed a novel comprehensive in silico pipeline for detecting tumor-specific splicing events (neojunctions) across multiple cancer types…

144 Novel public and tumor-wide neoantigens arising from clonal aberrant splicing events drive tumor-specific T-cell responses across diverse cancer types Open

Darwin Kwok, Nicholas Stevers, Takahide Nejo, Jangham Jung, Kaori Okada , et al. · 2023

Background Immunotherapy in gliomas is limited by tumor heterogeneity and low mutational burden. We developed a novel comprehensive in silico pipeline for detecting tumor-specific splicing events (neojunctions) across multiple cance…

Tumor-wide RNA splicing aberrations generate immunogenic public neoantigens Open

Darwin Kwok, Nicholas Stevers, Takahide Nejo, Lee H. Chen, Iñaki Etxeberría , et al. · 2023

Summary T-cell-mediated immunotherapies are limited by the extent to which cancer-specific antigens are homogenously expressed throughout a tumor. We reasoned that recurrent splicing aberrations in cancer represent a potential source of tu…

METB-13. A SINGLE-CELL GENETIC IN VIVO LINEAGE-TRACING PLATFORM FOR MEDULLOBLASTOMA Open

Jangham Jung, Bohyeon Yu, Owen Hoare, Aarón Díaz · 2023

Comparative single-cell studies of group 3/4 medulloblastomas (MBs) and fetal brain have identified a common hierarchy of glutamatergic-lineage cell types and an apparent cell-of-origin in the rhombic lip. An increased understanding of the…

MDB-14. MULTI-OMICS OF HUMAN MEDULLOBLASTOMAS AND GENETIC LINEAGE TRACING IN VIVO IDENTIFY REGULATORS OF STEM-CELL MAINTENANCE Open

Bohyeon Yu, Jangham Jung, Owen Hoare, Karin Shamardani, Aarón Díaz · 2023

Recent studies implicate the glutamatergic lineage of the rhombic lip (RL) as the origin of group 3/4 medulloblastomas (MBs). MB stem cells resemble stalled RL progenitors and targeting common pluripotency factors induces differentiated ph…

IMMU-09. DISSECTING THE INTERPLAY BETWEEN THE ENDOGENOUS IMMUNE RESPONSE AND ONCOLYTIC VIRUS THERAPY IN PEDIATRIC BRAIN TUMORS Open

Owen Hoare, Jangham Jung, Akihito Inagaki, Bohyeon Yu, Sara Collins , et al. · 2023

Oncolytic virus (OV) elicits an antitumor immune response in addition to tumor-cell killing. However, it is unknown if a pre-existing antitumor immune response aids or hinders OV therapy. To study the interplay between the endogenous immun…

Glioblastoma induces the recruitment and differentiation of hybrid neutrophils from skull bone marrow Open

Meeki Lad, Angad Beniwal, Saket Jain, Poojan Shukla, Jangham Jung , et al. · 2023

SUMMARY Tumor-associated neutrophil (TAN) effects on glioblastoma biology remain under-characterized. We show here that ‘hybrid’ neutrophils with dendritic features – including morphological complexity, expression of antigen presentation g…

Glioblastoma Induces the Recruitment and Differentiation of Hybrid Neutrophils from Skull Bone Marrow Open

Meeki Lad, Angad Beniwal, Saket Jain, Poojan Shukla, Jangham Jung , et al. · 2023

Transcriptomic Profiles of Normal Pituitary Cells and Pituitary Neuroendocrine Tumor Cells Open

Jun Yeop Oh, Robert C. Osorio, Jangham Jung, Luis Carrete, Nikita Choudhary , et al. · 2022

The pituitary gland is one of the most cellularly diverse regions of the brain. Recent advancements in transcriptomic biology, such as single-cell RNA sequencing, bring an unprecedented glimpse into the molecular composition of the pituita…

A single-cell atlas of glioblastoma evolution under therapy reveals cell-intrinsic and cell-extrinsic therapeutic targets Open

Lin Wang, Jangham Jung, Husam Babikir, Karin Shamardani, Saket Jain , et al. · 2022

Recent longitudinal studies of glioblastoma (GBM) have demonstrated a lack of apparent selection pressure for specific DNA mutations in recurrent disease. Single-cell lineage tracing has shown that GBM cells possess a high degree of plasti…

PATH-07. MULTIPLATFORM MOLECULAR ANALYSES REFINE CLASSIFICATION AND PROGNOSTICATION OF GLIOMAS ARISING IN PATIENTS WITH NEUROFIBROMATOSIS TYPE 1 Open

Calixto‐Hope G. Lucas, Emily A. Sloan, Jangham Jung, Rohit Gupta, Jasper Wu , et al. · 2022

BACKGROUND Gliomas arising in patients with neurofibromatosis type 1 (NF1) are heterogeneous, occurring from childhood through adulthood, can be histologically low-grade (LG) or high-grade (HG), and follow an indolent or aggressive clinica…

MEDB-59. A draft atlas of medulloblastoma cellular evolution under therapy Open

Lin Wang, Jangham Jung, Husam Babikir, Karin Shamardani, Noriyuki Kasahara , et al. · 2022

How standard care shapes the cellular composition of recurrent medulloblastoma (MB), if therapy selects for specific tumor or immune cell types, is unknown. We report the pilot phase of our ongoing effort to profile human longitudinal MB s…

IQ-Switch is a QF-based innocuous, silencing-free, and inducible gene switch system in zebrafish Open

Jeongkwan Hong, Jae Geun Lee, Kyung‐Cheol Sohn, Kayoung Lee, Seoee Lee , et al. · 2021

2-Photon Imaging of Macrophage-Driven Calcium Responses in Lung Fibroblasts Open

Patricia de la Torre, Arinjita Bhattacharyya, Tsai‐Wen Chen, T. Tsukui, D. Sheppard , et al. · 2021

Kapd Is Essential for Specification of the Dopaminergic Neurogenesis in Zebrafish Embryos Open

Jangham Jung, Eunhee Kim, Myungchull Rhee · 2021

<i>Trim46</i> contributes to the midbrain development via Sonic Hedgehog signaling pathway in zebrafish embryos Open

Jangham Jung, Jae‐Hun Kim, Tae‐Lin Huh, Myungchull Rhee · 2021

TRIM46 is a RING finger E3 ligase which belongs to TRIM (tripartite motif-containing) protein family. TRIM46 is required for neuronal polarity and axon specification by driving the formation of parallel microtubule arrays, whereas its embr…

<i>march5</i> Governs the Convergence and Extension Movement for Organization of the Telencephalon and Diencephalon in Zebrafish Embryos. Open

Jangham Jung, Issac Choi, Hyunju Ro, Tae‐Lin Huh, Joonho Choe , et al. · 2020

MARCH5 is a RING finger E3 ligase involved in mitochondrial integrity, cellular protein homeostasis, and the regulation of mitochondrial fusion and fission. To determine the function of MARCH5 during development, we assessed transcript exp…

Znf76 is associated with development of the eyes, midbrain, MHB, and hindbrain in zebrafish embryos Open

Jangham Jung, S. Udhaya Kumar, Issac Choi, Tea-Lin Huh, Myungchull Rhee · 2019

ZNF76 is a transcriptional repressor that targets the TATA-binding protein (TBP) and plays an essential role during brain development; however, its function during embryogenesis remains unclear. Here, we report the expression pattern and p…

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