Janice Brewer
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View article: Infiltrative lymphocytic hypophysitis successfully treated with rituximab and mycophenolate mofetil
Infiltrative lymphocytic hypophysitis successfully treated with rituximab and mycophenolate mofetil Open
Summary Lymphocytic hypophysitis is a rare neuroendocrine disease characterised by an autoimmune inflammatory disorder of the pituitary gland. We report a 50-year-old woman who presented with headaches and bilateral sixth cranial nerve pal…
View article: Molecular and clonal evolution in recurrent metastatic gliosarcoma
Molecular and clonal evolution in recurrent metastatic gliosarcoma Open
We discuss the molecular evolution of gliosarcoma, a mesenchymal type of glioblastoma (GBM), using the case of a 37-yr-old woman who developed two recurrences and an extracranial metastasis. She was initially diagnosed with isocitrate dehy…
View article: COMP-15. MOLECULAR AND CLONAL EVOLUTION IN RECURRENT METASTATIC GLIOSARCOMA
COMP-15. MOLECULAR AND CLONAL EVOLUTION IN RECURRENT METASTATIC GLIOSARCOMA Open
Gliosarcoma, a World Health Organization grade IV glioma, is a rare variant of glioblastoma (GBM) that contains distinct glial and mesenchymal components. Histologically, the glial component matches criteria for glioblastoma, and both comp…
View article: Lymphocytic Hypophysitis Presenting as Bilateral Abducens Nerve Palsy: A Case Report
Lymphocytic Hypophysitis Presenting as Bilateral Abducens Nerve Palsy: A Case Report Open
Lymphocytic hypophysitis (LYH) is a neuroendocrine disorder characterised by autoimmune inflammation of the pituitary gland with varying degrees of pituitary dysfunction, visual field defects and ocular motility disturbance. The authors re…
View article: ASCIA‐P76: SULPHASALAZINE‐INDUCED DRUG REACTION WITH EOSINOPHILIA AND SYSTEMIC SYMPTOMS (DRESS) ASSOCIATED WITH NECROTISING EOSINOPHILIC MYOSITIS – A NOVEL FINDING
ASCIA‐P76: SULPHASALAZINE‐INDUCED DRUG REACTION WITH EOSINOPHILIA AND SYSTEMIC SYMPTOMS (DRESS) ASSOCIATED WITH NECROTISING EOSINOPHILIC MYOSITIS – A NOVEL FINDING Open
Drug reaction with eosinophilia and systemic symptoms (DRESS) is a rare and potentially life threatening drug hypersensitivity reaction characterised by fever, rash, eosinophilia and/or other haematological abnormalities, and organ involve…
View article: Mutations in <i>HSPB8</i> causing a new phenotype of distal myopathy and motor neuropathy
Mutations in <i>HSPB8</i> causing a new phenotype of distal myopathy and motor neuropathy Open
We expand the understanding of disease mechanisms, tissue involvement, and phenotypic outcome of HSPB8 mutations. HSPB8 is part of the chaperone-assisted selective autophagy (CASA) complex previously only associated with Charcot-Marie-Toot…
View article: Differences in the Pathological Diagnosis and Repeat Craniotomy Rates in Cerebral Tumors Undergoing Biopsy or Resection in an Urban Versus Regional Center
Differences in the Pathological Diagnosis and Repeat Craniotomy Rates in Cerebral Tumors Undergoing Biopsy or Resection in an Urban Versus Regional Center Open
Primary intracranial tumors occur with an incidence of between 2.5 and 6 per 100,000 individuals. They require specialist expertise for investigation and management including input from radiology, pathology, neurosurgery, and oncology. The…