Janina Bahnemann
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View article: Smarter cell sorting: droplet microfluidics meets pick-and-place sorting
Smarter cell sorting: droplet microfluidics meets pick-and-place sorting Open
A microfluidic transfer tool (MTT) was designed to pick objects and store them intermediately in a droplet sequence before placement. Overall system achieved a significantly increased throughput when sorting 50 μm polymer beads or 20 μm pl…
View article: Influence of species composition and cultivation condition on peri-implant biofilm dysbiosis in vitro
Influence of species composition and cultivation condition on peri-implant biofilm dysbiosis in vitro Open
Introduction Changes in bacterial species composition within oral biofilms, known as biofilm dysbiosis, are associated with the development of severe oral diseases. To better understand this process and help establish early detection syste…
View article: Neural network-based image analysis of co-localized microorganisms and human cells on implant materials
Neural network-based image analysis of co-localized microorganisms and human cells on implant materials Open
Dental implant-associated infections increase the risk of implant failure, presenting significant challenges in modern dentistry. The host-microbe interaction plays a crucial role in the development of implant-associated infections. To gai…
View article: Differentiation and identification of commensal and pathogenic oral bacteria at strain level using ATR-FTIR spectroscopy
Differentiation and identification of commensal and pathogenic oral bacteria at strain level using ATR-FTIR spectroscopy Open
The correct identification of different bacteria is a critical task in clinical applications and basic research especially in the oral cavity which has a complex bacterial community. Complementary to a variety of phenotyping and genotyping…
View article: A 3D‐Printed Microfluidic Sensor Platform for Online Bioprocess Monitoring
A 3D‐Printed Microfluidic Sensor Platform for Online Bioprocess Monitoring Open
In order to screen for optimal bioprocess parameters at higher throughput, researchers developing new biopharmaceuticals are increasingly turning to miniaturized cultivation systems with reduced space and media consumption. However, these …
View article: Influence of species composition and cultivation condition on peri-implant biofilm dysbiosis in vitro
Influence of species composition and cultivation condition on peri-implant biofilm dysbiosis in vitro Open
Background Changes in bacterial species composition within oral biofilms, known as biofilm dysbiosis, are associated with the development of severe oral diseases. To better understand this process and help establish early detection systems…
View article: Porous silicon biosensors meet zwitterionic peptides: tackling biofouling from proteins to cells
Porous silicon biosensors meet zwitterionic peptides: tackling biofouling from proteins to cells Open
A zwitterionic peptide-functionalized porous silicon aptasensor enables ultrasensitive biomarker detection in complex biological samples.
View article: Differentiation and identification of commensal and pathogenic oral bacteria at strain level using ATR-FTIR spectroscopy
Differentiation and identification of commensal and pathogenic oral bacteria at strain level using ATR-FTIR spectroscopy Open
FTIR spectroscopy enables the correct identification of different oral bacterial species. Combined with machine learning, the technique is able to classify clinical isolates of oral pathogens at the strain level.
View article: Exploring Endothelial Cell Adhesion to High-Resolution 3D Printing Materials for Advanced Organ-on-Chip Fabrication
Exploring Endothelial Cell Adhesion to High-Resolution 3D Printing Materials for Advanced Organ-on-Chip Fabrication Open
With advancements in resolution, 3D printing is emerging as a transformative technology for the rapid fabrica-tion of cell culture systems, including organ-on-chip platforms. For successful integration into cell culture en-vironments, 3D p…
View article: Automated electrochemical oxygen sensing using a 3D-printed microfluidic lab-on-a-chip system
Automated electrochemical oxygen sensing using a 3D-printed microfluidic lab-on-a-chip system Open
A 3D-printed optical-electrochemical microfluidic device able to automatically flow and measure dissolved oxygen in physiologically relevant levels.
View article: 3D-printed microfluidic cell culture devices and hydrogel integration: Trends, challenges and solutions
3D-printed microfluidic cell culture devices and hydrogel integration: Trends, challenges and solutions Open
3D cell cultures are increasingly being used in a variety of contexts – including for drug discovery, disease modelling, and tissue engineering – because they offer the potential to increase physiological relevance compared to …
View article: Optically accessible, 3D-printed flow chamber with integrated sensors for the monitoring of oral multispecies biofilm growth in vitro
Optically accessible, 3D-printed flow chamber with integrated sensors for the monitoring of oral multispecies biofilm growth in vitro Open
The formation of pathogenic multispecies biofilms in the human oral cavity can lead to implant-associated infections, which may ultimately result in implant failure. These infections are neither easily detected nor readily treated. Due to …
View article: 3D Printing in Biocatalysis and Biosensing: From General Concepts to Practical Applications
3D Printing in Biocatalysis and Biosensing: From General Concepts to Practical Applications Open
3D printing has matured into a versatile technique that offers researchers many different printing methods and materials with varying properties. Nowadays, 3D printing is deployed within a myriad of different applications, ranging from che…
View article: Design and Fabrication of 3D‐Printed Lab‐On‐A‐Chip Devices for Fiber‐Based Optical Chromatography and Sorting
Design and Fabrication of 3D‐Printed Lab‐On‐A‐Chip Devices for Fiber‐Based Optical Chromatography and Sorting Open
Microfluidic lab‐on‐a‐chip (LOC) devices have become essential tools for multitudes of applications in various research fields. 3D printing of microfluidic LOC devices offers many advantages over more traditional manufacturing processes, i…
View article: Microfluidic Transfection System and Temperature Strongly Influence the Efficiency of Transient Transfection
Microfluidic Transfection System and Temperature Strongly Influence the Efficiency of Transient Transfection Open
For the process of transient transfection (TTF), DNA is often transported into the cells using polyplexes. The polyplex uptake and the subsequent transient expression of the gene of interest are of great importance for a successful transfe…
View article: Enhancing porous silicon biosensors performance: the interplay of nanostructure design and microfluidic integration
Enhancing porous silicon biosensors performance: the interplay of nanostructure design and microfluidic integration Open
In this article, we investigate mass transfer acceleration approaches aimed at enhancing the performance of porous silicon (PSi)-based biosensors. PSi biosensors tend to suffer from relatively poor sensitivity due to mass transfer limitati…
View article: A Novel 3D-Printed and Miniaturized Periodic Counter Current Chromatography System for Continuous Purification of Monoclonal Antibodies
A Novel 3D-Printed and Miniaturized Periodic Counter Current Chromatography System for Continuous Purification of Monoclonal Antibodies Open
Continuous chromatography has emerged as one of the most attractive methods for protein purification. Establishing such systems involves installing several chromatographic units in series to enable continuous separation processes and reduc…
View article: Photonic Si microwell architectures for rapid antifungal susceptibility determination of <i>Candida auris</i>
Photonic Si microwell architectures for rapid antifungal susceptibility determination of <i>Candida auris</i> Open
The application of a photonic silicon chip-based optical sensor system for expeditious and phenotypic antifungal susceptibility testing of Candida auris is presented.
View article: 3D-Printed Microfluidic Perfusion System for Parallel Monitoring of Hydrogel-Embedded Cell Cultures
3D-Printed Microfluidic Perfusion System for Parallel Monitoring of Hydrogel-Embedded Cell Cultures Open
The use of three-dimensional (3D) cell cultures has become increasingly popular in the contexts of drug discovery, disease modelling, and tissue engineering, as they aim to replicate in vivo-like conditions. To achieve this, new hydrogels …
View article: Establishment of a Perfusion Process with Antibody-Producing CHO Cells Using a 3D-Printed Microfluidic Spiral Separator with Web-Based Flow Control
Establishment of a Perfusion Process with Antibody-Producing CHO Cells Using a 3D-Printed Microfluidic Spiral Separator with Web-Based Flow Control Open
Monoclonal antibodies are increasingly dominating the market for human therapeutic and diagnostic agents. For this reason, continuous methods—such as perfusion processes—are being explored and optimized in an ongoing effort to increase pro…
View article: 3D-Druck zur Miniaturisierung von chromatographischen Anwendungen
3D-Druck zur Miniaturisierung von chromatographischen Anwendungen Open
3D printing as a tool for prototyping is already well established in many areas of biotechnology. Whether for the production of individual laboratory devices, for the development of biocompatible devices for cell cultivation or even lab-on…
View article: Enhancing stability of recombinant CHO cells by CRISPR/Cas9-mediated site-specific integration into regions with distinct histone modifications
Enhancing stability of recombinant CHO cells by CRISPR/Cas9-mediated site-specific integration into regions with distinct histone modifications Open
Chinese hamster ovary (CHO) cells are the most important platform for producing biotherapeutics. Random integration of a transgene into epigenetically instable regions of the genome results in silencing of the gene of interest and loss of …
View article: 3D‐printed autoclavable plant holders to facilitate large‐scale protein production in plants
3D‐printed autoclavable plant holders to facilitate large‐scale protein production in plants Open
The Australian tobacco plant Nicotiana benthamiana is becoming increasingly popular as a platform for protein production and metabolic engineering. In this system, gene expression is achieved transiently by infiltrating N. benthamiana plan…
View article: Optimization of a mAb production process with regard to robustness and product quality using quality by design principles
Optimization of a mAb production process with regard to robustness and product quality using quality by design principles Open
Quality by Design principles are well described and widely used in biopharmaceutical industry. The characterization of a monoclonal antibody (mAb) production process is crucial for novel process development and control. Yet, the applicatio…