Janine E. Deakin
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View article: The role of unbalanced segmental duplication in sex chromosome evolution in Australian ridge-tailed goannas
The role of unbalanced segmental duplication in sex chromosome evolution in Australian ridge-tailed goannas Open
Varanids are known for conserved sex chromosomes, but there are differences in the size of the W chromosome among species representing varying stages of sex chromosome evolution. We tested for homology of the ZW sex chromosome system with …
View article: Fixed Allele Differences Associated With the Centromere Reveal Chromosome Morphology and Rearrangements in a Reptile (<i>Varanus acanthurus</i> BOULENGER)
Fixed Allele Differences Associated With the Centromere Reveal Chromosome Morphology and Rearrangements in a Reptile (<i>Varanus acanthurus</i> BOULENGER) Open
Chromosome rearrangements are often implicated with genomic divergence and are proposed to be associated with species evolution. Rearrangements alter the genomic structure and interfere with homologous recombination by isolating a portion …
View article: Unbalanced segmental duplication of W chromosomes in Australian Ridge-tailed goannas
Unbalanced segmental duplication of W chromosomes in Australian Ridge-tailed goannas Open
Sex chromosomes are mostly conserved, but in some cases are variable within species. Varanids are known for conserved sex chromosomes, but there are differences in the size of the W chromosome among species representing varying stages of s…
View article: Principles of 3D chromosome folding and evolutionary genome reshuffling in mammals
Principles of 3D chromosome folding and evolutionary genome reshuffling in mammals Open
Studying the similarities and differences in genomic interactions between species provides fertile grounds for determining the evolutionary dynamics underpinning genome function and speciation. Here, we describe the principles of 3D genome…
View article: Extreme genetic divergence indicated by chromosome rearrangements
Extreme genetic divergence indicated by chromosome rearrangements Open
Chromosomal rearrangements are often associated with local adaptation and speciation because they suppress recombination, and as a result, rearrangements have been implicated in disrupting geneflow. Although there is strong evidence to sug…
View article: Sex-linked markers in an Australian frog <i>Platyplectrum ornatum</i> with a small genome and homomorphic sex chromosomes
Sex-linked markers in an Australian frog <i>Platyplectrum ornatum</i> with a small genome and homomorphic sex chromosomes Open
Amphibians have highly diverse sex-determining modes leading to a notable interest in vertebrate sex determination and sex chromosome evolution. The identification of sex-determining systems in amphibians, however, is often difficult as a …
View article: Sex-specific splicing of Z- and W-borne<i>nr5a1</i>alleles suggests sex determination is controlled by chromosome conformation
Sex-specific splicing of Z- and W-borne<i>nr5a1</i>alleles suggests sex determination is controlled by chromosome conformation Open
Significance Reptiles have an extraordinary variety of mechanisms to determine sex. The best candidate sex-determining gene in our model reptile (the Australian central bearded dragon) is the key vertebrate sex gene nr5a1 (coding for the s…
View article: Sex-linked markers in an Australian frog Platyplectrum ornatum with a small genome and homomorphic sex chromosomes
Sex-linked markers in an Australian frog Platyplectrum ornatum with a small genome and homomorphic sex chromosomes Open
The DArTseq data that used in the investigation for the mode of sex determination in Platyplectrum ornatum.
View article: Limited Introgression between Rock-Wallabies with Extensive Chromosomal Rearrangements
Limited Introgression between Rock-Wallabies with Extensive Chromosomal Rearrangements Open
Chromosome rearrangements can result in the rapid evolution of hybrid incompatibilities. Robertsonian fusions, particularly those with monobrachial homology, can drive reproductive isolation amongst recently diverged taxa. The recent radia…
View article: Identification of Y chromosome markers in the eastern three-lined skink (Bassiana duperreyi) using in silico whole genome subtraction.
Identification of Y chromosome markers in the eastern three-lined skink (Bassiana duperreyi) using in silico whole genome subtraction. Open
Background: Homologous sex chromosomes can differentiate over time because recombination is suppressed in the region of the sex determining locus, leading to the accumulation of repeats, progressive loss of genes that lack differential inf…
View article: Identification of Y chromosome markers in the eastern three-lined skink (Bassiana duperreyi) using in-silico whole genome subtraction.
Identification of Y chromosome markers in the eastern three-lined skink (Bassiana duperreyi) using in-silico whole genome subtraction. Open
Background: Homologous sex chromosomes can differentiate over time because recombination is suppressed in the region of the sex determining locus, leading to the accumulation of repeats, progressive loss of genes that lack differential inf…
View article: Identification of Y chromosome markers in the eastern three-lined skink (Bassiana duperreyi) using in-silico whole genome subtraction.
Identification of Y chromosome markers in the eastern three-lined skink (Bassiana duperreyi) using in-silico whole genome subtraction. Open
Background: Homologous sex chromosomes can differentiate over time because recombination is suppressed in the region of the sex determining locus, leading to the accumulation of repeats, progressive loss of genes that lack differential inf…
View article: Identification of Y chromosome markers in the eastern three-lined skink (Bassiana duperreyi) using in-silico whole genome subtraction.
Identification of Y chromosome markers in the eastern three-lined skink (Bassiana duperreyi) using in-silico whole genome subtraction. Open
Background: Homologous sex chromosomes can differentiate over time because recombination is suppressed in the region of the sex determining locus, leading to the accumulation of repeats, progressive loss of genes that lack differential inf…
View article: Identification of Y chromosome markers in the eastern three-lined skink (Bassiana duperreyi) using in-silico whole genome subtraction.
Identification of Y chromosome markers in the eastern three-lined skink (Bassiana duperreyi) using in-silico whole genome subtraction. Open
Background: Homologous sex chromosomes can differentiate over time because recombination is suppressed in the region of the sex determining locus, leading to the accumulation of repeats, progressive loss of genes that lack differential inf…
View article: Comparative Cytogenetic Mapping and Telomere Analysis Provide Evolutionary Predictions for Devil Facial Tumour 2
Comparative Cytogenetic Mapping and Telomere Analysis Provide Evolutionary Predictions for Devil Facial Tumour 2 Open
The emergence of a second transmissible tumour in the Tasmanian devil population, devil facial tumour 2 (DFT2), has prompted questions on the origin and evolution of these transmissible tumours. We used a combination of cytogenetic mapping…
View article: Identification of Y chromosome markers in the eastern three-lined skink (Bassiana duperreyi) using in-silico whole genome subtraction.
Identification of Y chromosome markers in the eastern three-lined skink (Bassiana duperreyi) using in-silico whole genome subtraction. Open
Background: Homologous sex chromosomes can differentiate over time because recombination is suppressed in the region of the sex determining locus, leading to the accumulation of repeats, progressive loss of genes that lack differential inf…
View article: Chromosomics: Bridging the Gap between Genomes and Chromosomes
Chromosomics: Bridging the Gap between Genomes and Chromosomes Open
The recent advances in DNA sequencing technology are enabling a rapid increase in the number of genomes being sequenced. However, many fundamental questions in genome biology remain unanswered, because sequence data alone is unable to prov…
View article: Sexual conflict in action: An antagonistic relationship between maternal and paternal sex allocation in the tammar wallaby, <i>Notamacropus eugenii</i>
Sexual conflict in action: An antagonistic relationship between maternal and paternal sex allocation in the tammar wallaby, <i>Notamacropus eugenii</i> Open
Sex ratio biases are often inconsistent, both among and within species and populations. While some of these inconsistencies may be due to experimental design, much of the variation remains inexplicable. Recent research suggests that an exc…
View article: Chromosome Evolution in Marsupials
Chromosome Evolution in Marsupials Open
Marsupials typically possess very large, distinctive chromosomes that make them excellent subjects for cytogenetic analysis, and the high level of conservation makes it relatively easy to track chromosome evolution. There are two speciose …
View article: Identification of candidate genes for devil facial tumour disease tumourigenesis
Identification of candidate genes for devil facial tumour disease tumourigenesis Open
Devil facial tumour (DFT) disease, a transmissible cancer where the infectious agent is the tumour itself, has caused a dramatic decrease in Tasmanian devil numbers in the wild. The purpose of this study was to take a candidate gene/pathwa…
View article: Chromosomal Speciation in the Genomics Era: Disentangling Phylogenetic Evolution of Rock-wallabies
Chromosomal Speciation in the Genomics Era: Disentangling Phylogenetic Evolution of Rock-wallabies Open
The association of chromosome rearrangements (CRs) with speciation is well established, and there is a long history of theory and evidence relating to "chromosomal speciation." Genomic sequencing has the potential to provide new insights i…