Janine H. Santos
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View article: Antiretroviral therapy in the peripartum period impairs post pregnancy cardiac reverse remodeling with early signs of heart failure with preserved ejection fraction
Antiretroviral therapy in the peripartum period impairs post pregnancy cardiac reverse remodeling with early signs of heart failure with preserved ejection fraction Open
Cardiovascular (CV) disease in pregnancy is the leading cause of maternal mortality worldwide, often associated with the cardiometabolic remodeling needed for fetal growth. In healthy pregnancies these changes reverse postpartum with no co…
View article: Gestational exposure to HIV drugs alters intestinal mucosa-associated microbial diversity in adult rat offspring
Gestational exposure to HIV drugs alters intestinal mucosa-associated microbial diversity in adult rat offspring Open
The antiretroviral (ARV) drug combination of abacavir sulfate, dolutegravir, and lamivudine [ABC/DTG/3TC; Tri combination Anti-retroviral therapy (TC-ART)] has revolutionized HIV treatment by effectively targeting different stages of viral…
View article: Chronic PFAS exposure induces chemotherapy resistance by promoting mitochondria-related alterations in ovarian cancer cells
Chronic PFAS exposure induces chemotherapy resistance by promoting mitochondria-related alterations in ovarian cancer cells Open
Resistance to chemotherapy is a major barrier to the effective treatment of ovarian cancer; however, the role of environmental exposures in the onset of chemoresistance remains elusive. Our previous work in ovarian cancer cells suggests th…
View article: Effect of in utero and lactational exposure to antiretroviral therapy on the gut microbial composition and metabolic function in aged rat offspring
Effect of in utero and lactational exposure to antiretroviral therapy on the gut microbial composition and metabolic function in aged rat offspring Open
Despite the highly effective impact of antiretroviral therapy (ART) in reducing mother-to-child transmission of human immunodeficiency virus (HIV), there are concerns of long-term impacts of ART on the health of the offspring. The implicat…
View article: Mitochondrial membrane hyperpolarization modulates nuclear DNA methylation and gene expression through phospholipid remodeling
Mitochondrial membrane hyperpolarization modulates nuclear DNA methylation and gene expression through phospholipid remodeling Open
View article: MICU1 and MICU2 control mitochondrial calcium signaling in the mammalian heart
MICU1 and MICU2 control mitochondrial calcium signaling in the mammalian heart Open
Activating Ca 2+ -sensitive enzymes of oxidative metabolism while preventing calcium overload that leads to mitochondrial and cellular injury requires dynamic control of mitochondrial Ca 2+ uptake. This is ensured by the mitochondrial calc…
View article: Mitochondrial membrane potential regulates nuclear DNA methylation and gene expression through phospholipid remodeling
Mitochondrial membrane potential regulates nuclear DNA methylation and gene expression through phospholipid remodeling Open
Summary Maintenance of the mitochondrial inner membrane potential (ΔΨM) is critical for many aspects of mitochondrial function, including mitochondrial protein import and ion homeostasis. While ΔΨM loss and its consequences are well studie…
View article: Answer to Gerber <i>et al.</i> “<i>Autosomal recessive pathogenic <scp>MSTO1</scp> variants in hereditary optic atrophy</i>”
Answer to Gerber <i>et al.</i> “<i>Autosomal recessive pathogenic <span>MSTO1</span> variants in hereditary optic atrophy</i>” Open
Gal et al address the issues raised by Gerber et al and reiterate that patients in their study showed decreased Misato homolog 1 (MSTO1) mRNA and protein levels, but also confirm finding of Gerber et al that the mutation is in MSTO2p pseud…
View article: Methods to Evaluate Changes in Mitochondrial Structure and Function in Cancer
Methods to Evaluate Changes in Mitochondrial Structure and Function in Cancer Open
Mitochondria are regulators of key cellular processes, including energy production and redox homeostasis. Mitochondrial dysfunction is associated with various human diseases, including cancer. Importantly, both structural and functional ch…
View article: Methods to Evaluate Changes in Mitochondrial Structure and Function in Cancer
Methods to Evaluate Changes in Mitochondrial Structure and Function in Cancer Open
Mitochondria are regulators of key cellular processes, including energy production and redox homeostasis. Mitochondrial dysfunction is associated with various human diseases, including cancer. Importantly, both structural and functional ch…
View article: Photochemical Targeting of Mitochondria to Overcome Chemoresistance in Ovarian Cancer<sup>†</sup>
Photochemical Targeting of Mitochondria to Overcome Chemoresistance in Ovarian Cancer<sup>†</sup> Open
Ovarian cancer is the most lethal gynecologic malignancy with a stubborn mortality rate of ~65%. The persistent failure of multiline chemotherapy, and significant tumor heterogeneity, has made it challenging to improve outcomes. A target o…
View article: Emerging mitochondrial signaling mechanisms in cardio-oncology: beyond oxidative stress
Emerging mitochondrial signaling mechanisms in cardio-oncology: beyond oxidative stress Open
Many anticancer therapies (CTx) have cardiotoxic side effects that limit their therapeutic potential and cause long-term cardiovascular complications in cancer survivors. This has given rise to the field of cardio-oncology, which recognize…
View article: NRF2 Alters Mitochondrial Gene Expression in Neonate Mice Exposed to Hyperoxia
NRF2 Alters Mitochondrial Gene Expression in Neonate Mice Exposed to Hyperoxia Open
Approximately 1 in 10 newborns are born preterm and require supplemental oxygen (O2) in an extrauterine environment following birth. Supplemental O2 can induce oxidative stress that can impair mitochondrial function, resulting in lung inju…
View article: Mitochondrial DNA damage as driver of cellular outcomes
Mitochondrial DNA damage as driver of cellular outcomes Open
Mitochondria are primarily involved in energy production through the process of oxidative phosphorylation (OXPHOS). Increasing evidence has shown that mitochondrial function impacts a plethora of different cellular activities, including me…
View article: Correction: A brain-specific PGC1a fusion transcript affects gene expression and behavioral outcomes in mice
Correction: A brain-specific PGC1a fusion transcript affects gene expression and behavioral outcomes in mice Open
It came to our attention that the Gene Chip utilized for microarray analysis wrongly indicated the Human GeneChip. Instead, the microarrays used the Affymetrix Mouse GeneChip as below. We apologize for the inconvenience; this correction be…
View article: A brain-specific pgc1α fusion transcript affects gene expression and behavioural outcomes in mice
A brain-specific pgc1α fusion transcript affects gene expression and behavioural outcomes in mice Open
PGC1α is a transcriptional coactivator in peripheral tissues, but its function in the brain remains poorly understood. Various brain-specific Pgc1α isoforms have been reported in mice and humans, including two fusion transcripts (FTs) with…
View article: A brain-specific <i>pgc1</i>α fusion transcript affects gene expression and behavioural outcomes in mice
A brain-specific <i>pgc1</i>α fusion transcript affects gene expression and behavioural outcomes in mice Open
PGC1α is a transcriptional coactivator in peripheral tissues, but its function in the brain remains poorly understood. Various brain-specific Pgc1 α isoforms have been reported in mice and humans, including two fusion transcripts (FTs) wit…
View article: Mitochondria signaling to the epigenome: A novel role for an old organelle
Mitochondria signaling to the epigenome: A novel role for an old organelle Open
View article: Mitochondrial DNA lesions and copy number are strain dependent in endurance‐trained mice
Mitochondrial DNA lesions and copy number are strain dependent in endurance‐trained mice Open
In this pilot work, we selected two inbred strains that respond well to endurance training (ET) (FVB/NJ, and SJL/J strains), and two strains that respond poorly (BALB/cByJ and NZW/LacJ), to determine the effect of a standardized ET treadmi…
View article: Mutations on a novel brain-specific isoform of PGC1α leads to extensive upregulation of neurotransmitter-related genes and sexually dimorphic motor deficits in mice
Mutations on a novel brain-specific isoform of PGC1α leads to extensive upregulation of neurotransmitter-related genes and sexually dimorphic motor deficits in mice Open
The peroxisome proliferator-activated receptor gamma co-activator 1 alpha (PGC1α) is known as a transcriptional co-activator in peripheral tissues but its function in the brain remains poorly understood. Various brain-specific Pgc1α isofor…
View article: Single Nucleotide Resolution Analysis Reveals Pervasive, Long-Lasting DNA Methylation Changes by Developmental Exposure to a Mitochondrial Toxicant
Single Nucleotide Resolution Analysis Reveals Pervasive, Long-Lasting DNA Methylation Changes by Developmental Exposure to a Mitochondrial Toxicant Open
Mitochondrial-driven alterations of the epigenome have been reported, but whether they are relevant at the organismal level remains unknown. The viable yellow agouti mouse (Avy) is a powerful epigenetic biosensor model that repo…
View article: Mitochondrial-related effects of pentabromophenol, tetrabromobisphenol A, and triphenyl phosphate on murine BV-2 microglia cells
Mitochondrial-related effects of pentabromophenol, tetrabromobisphenol A, and triphenyl phosphate on murine BV-2 microglia cells Open
View article: Locus coeruleus neurons are most sensitive to chronic neuroinflammation-induced neurodegeneration
Locus coeruleus neurons are most sensitive to chronic neuroinflammation-induced neurodegeneration Open
View article: Maternal exposure to a mitochondrial toxicant results in life-long alterations in DNA methylation and gene expression in the offspring
Maternal exposure to a mitochondrial toxicant results in life-long alterations in DNA methylation and gene expression in the offspring Open
Mitochondrial-driven alterations of the epigenome have been reported but whether they are relevant at the organismal level remain unknown. The viable yellow agouti mouse ( A vy ) is a powerful epigenetic biosensor model that reports on the…
View article: Mitochondrial Oxidative Phosphorylation defect in the Heart of Subjects with Coronary Artery Disease
Mitochondrial Oxidative Phosphorylation defect in the Heart of Subjects with Coronary Artery Disease Open
View article: Telomerase Impinges on the Cellular Response to Oxidative Stress Through Mitochondrial ROS-Mediated Regulation of Autophagy
Telomerase Impinges on the Cellular Response to Oxidative Stress Through Mitochondrial ROS-Mediated Regulation of Autophagy Open
Telomerase has cellular functions beyond telomere stabilization, including a role in mitochondria. The function of the catalytic component—TERT—in mitochondria is still unknown, but it seems to play a role in the response to oxidative stre…
View article: Mitochondrial acetyl-CoA reversibly regulates locus-specific histone acetylation and gene expression
Mitochondrial acetyl-CoA reversibly regulates locus-specific histone acetylation and gene expression Open
The impact of mitochondrial dysfunction in epigenetics is emerging, but our understanding of this relationship and its effect on gene expression remains incomplete. We previously showed that acute mitochondrial DNA (mtDNA) loss leads to hi…
View article: Mitochondrial acetyl-CoA reversibly regulates locus-specific histone acetylation and gene expression
Mitochondrial acetyl-CoA reversibly regulates locus-specific histone acetylation and gene expression Open
The impact of mitochondria in epigenetics is emerging but our understanding of this relationship and its impact on gene expression remain incomplete. We previously showed that acute mitochondrial DNA (mtDNA) loss leads to histone hypoacety…
View article: A Leveraged Signal-to-Noise Ratio (LSTNR) Method to Extract Differentially Expressed Genes and Multivariate Patterns of Expression From Noisy and Low-Replication RNAseq Data
A Leveraged Signal-to-Noise Ratio (LSTNR) Method to Extract Differentially Expressed Genes and Multivariate Patterns of Expression From Noisy and Low-Replication RNAseq Data Open
To life scientists, one important feature offered by RNAseq, a next-generation sequencing tool used to estimate changes in gene expression levels, lies in its unprecedented resolution. It can score countable differences in transcript numbe…
View article: Mitochondrial nicotinamide adenine dinucleotide reduced (NADH) oxidation links the tricarboxylic acid (TCA) cycle with methionine metabolism and nuclear DNA methylation
Mitochondrial nicotinamide adenine dinucleotide reduced (NADH) oxidation links the tricarboxylic acid (TCA) cycle with methionine metabolism and nuclear DNA methylation Open
Mitochondrial function affects many aspects of cellular physiology, and, most recently, its role in epigenetics has been reported. Mechanistically, how mitochondrial function alters DNA methylation patterns in the nucleus remains ill defin…