Janine Lützkendorf
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View article: Myosin 15 participates in assembly and remodeling of the presynapse.
Myosin 15 participates in assembly and remodeling of the presynapse. Open
The assembly and remodeling of presynaptic specializations are of crucial importance for circuit development and adaptive behaviors. However, the mechanisms by which presynaptic material is locally distributed within synaptic terminals and…
View article: Autophagy-driven Presynaptic Reorganization as a Molecular Signature of Brain Resilience
Autophagy-driven Presynaptic Reorganization as a Molecular Signature of Brain Resilience Open
Neural circuits must remain functionally stable while responding flexibly to changing demands, stressors, and aging-related decline. While this balance is thought to be maintained through plasticity programs that integrate molecular, metab…
View article: Condensate dynamics at the synapse: Phase separation tunes presynaptic function
Condensate dynamics at the synapse: Phase separation tunes presynaptic function Open
A new study in PLOS Biology shows that Liprin-α and RIM form condensates which not only scaffold presynaptic protein architectures but also fine-tune vesicle priming and release dynamics.
View article: Blobby is a synaptic active zone assembly protein required for memory in Drosophila
Blobby is a synaptic active zone assembly protein required for memory in Drosophila Open
View article: Identification and characterization of a synaptic active zone assembly protein
Identification and characterization of a synaptic active zone assembly protein Open
At presynaptic active zones (AZs), scaffold proteins play a crucial role in coordinating synaptic vesicle (SV) release and forming intricate nanoarchitectures essential for synaptic function. Despite their suspected importance, factors gov…
View article: An antagonism between Spinophilin and Syd-1 operates upstream of memory-promoting presynaptic long-term plasticity
An antagonism between Spinophilin and Syd-1 operates upstream of memory-promoting presynaptic long-term plasticity Open
We still face fundamental gaps in understanding how molecular plastic changes of synapses intersect with circuit operation to define behavioral states. Here, we show that an antagonism between two conserved regulatory proteins, Spinophilin…
View article: Author response: An antagonism between Spinophilin and Syd-1 operates upstream of memory-promoting presynaptic long-term plasticity
Author response: An antagonism between Spinophilin and Syd-1 operates upstream of memory-promoting presynaptic long-term plasticity Open
View article: Interactive nanocluster compaction of the ELKS scaffold and Cacophony Ca <sup>2+</sup> channels drives sustained active zone potentiation
Interactive nanocluster compaction of the ELKS scaffold and Cacophony Ca <sup>2+</sup> channels drives sustained active zone potentiation Open
At presynaptic active zones (AZs), conserved scaffold protein architectures control synaptic vesicle (SV) release by defining the nanoscale distribution and density of voltage-gated Ca 2+ channels (VGCCs). While AZs can potentiate SV relea…
View article: An antagonism between Spinophilin and Syd-1 operates upstream of memory-promoting presynaptic long-term plasticity
An antagonism between Spinophilin and Syd-1 operates upstream of memory-promoting presynaptic long-term plasticity Open
We still face fundamental gaps in understanding how molecular plastic changes of synapses intersect with circuit operation to define behavioral states. Here we show that an antagonism between two conserved regulatory proteins, Spinophilin …
View article: An active zone state switch concentrates and immobilizes voltage-gated Ca2+ channels to promote long-term plasticity
An active zone state switch concentrates and immobilizes voltage-gated Ca2+ channels to promote long-term plasticity Open
A molecularly diverse spectrum of plasticity mechanisms orchestrates brain information processing and storage via positive (“Hebbian”) and negative (“homeostatic”) feedbacks, which, however, mechanistically converge and functionally intera…
View article: eIF5A hypusination, boosted by dietary spermidine, protects from premature brain aging and mitochondrial dysfunction
eIF5A hypusination, boosted by dietary spermidine, protects from premature brain aging and mitochondrial dysfunction Open
Mitochondrial function declines during brain aging and is suspected to play a key role in age-induced cognitive decline and neurodegeneration. Supplementing levels of spermidine, a body-endogenous metabolite, has been shown to promote mito…
View article: Rab2 regulates presynaptic precursor vesicle biogenesis at the trans-Golgi
Rab2 regulates presynaptic precursor vesicle biogenesis at the trans-Golgi Open
Reliable delivery of presynaptic material, including active zone and synaptic vesicle proteins from neuronal somata to synaptic terminals, is prerequisite for successful synaptogenesis and neurotransmission. However, molecular mechanisms c…
View article: Presynaptic precursor vesicles originate from the<i>trans</i>-Golgi network, promoted by the small GTPase RAB2
Presynaptic precursor vesicles originate from the<i>trans</i>-Golgi network, promoted by the small GTPase RAB2 Open
Summary Reliable delivery of presynaptic material, including active zone and synaptic vesicle proteins from neuronal somata to synaptic terminals is prerequisite for faithful synaptogenesis and neurotransmission. However, molecular mechani…
View article: RIM-binding protein couples synaptic vesicle recruitment to release sites
RIM-binding protein couples synaptic vesicle recruitment to release sites Open
At presynaptic active zones, arrays of large conserved scaffold proteins mediate fast and temporally precise release of synaptic vesicles (SVs). SV release sites could be identified by clusters of Munc13, which allow SVs to dock in defined…
View article: Phosphorylation of the Bruchpilot N-terminus in <i>Drosophila</i> unlocks axonal transport of active zone building blocks
Phosphorylation of the Bruchpilot N-terminus in <i>Drosophila</i> unlocks axonal transport of active zone building blocks Open
Protein scaffolds at presynaptic active zone membranes control information transfer at synapses. For scaffold biogenesis and maintenance, scaffold components must be safely transported along axons. A spectrum of kinases has been suggested …
View article: Active zone scaffolds differentially accumulate Unc13 isoforms to tune Ca2+ channel–vesicle coupling
Active zone scaffolds differentially accumulate Unc13 isoforms to tune Ca2+ channel–vesicle coupling Open
View article: Presynaptic spinophilin tunes neurexin signalling to control active zone architecture and function
Presynaptic spinophilin tunes neurexin signalling to control active zone architecture and function Open