Janine M. May
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View article: The Antibiotic Novobiocin Binds and Activates the ATPase That Powers Lipopolysaccharide Transport
The Antibiotic Novobiocin Binds and Activates the ATPase That Powers Lipopolysaccharide Transport Open
Novobiocin is an orally active antibiotic that inhibits DNA gyrase by binding the ATP-binding site in the ATPase subunit. Although effective against Gram-positive pathogens, novobiocin has limited activity against Gram-negative organisms d…
View article: Identification of Residues in the Lipopolysaccharide ABC Transporter That Coordinate ATPase Activity with Extractor Function
Identification of Residues in the Lipopolysaccharide ABC Transporter That Coordinate ATPase Activity with Extractor Function Open
The surface of most Gram-negative bacteria is covered with lipopolysaccharide (LPS), creating a permeability barrier against toxic molecules, including many antimicrobials. To assemble LPS on their surface, Gram-negative bacteria must extr…
View article: An antibiotic binds to the ATPase that powers lipopolysaccharide transport
An antibiotic binds to the ATPase that powers lipopolysaccharide transport Open
The spread of antibiotic resistance has created an urgent need for new antibiotics. The situation is particularly serious for Gram-negative bacteria because they possess an outer membrane (OM) that prevents many antibiotics from entering t…