Janne Kaskinoro
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View article: Development and Preclinical Evaluation of a Copper-64-Labeled Antibody Targeting Glycine-Alanine Dipeptides for PET Imaging of C9orf72-Associated Amyotrophic Lateral Sclerosis/Frontotemporal Dementia
Development and Preclinical Evaluation of a Copper-64-Labeled Antibody Targeting Glycine-Alanine Dipeptides for PET Imaging of C9orf72-Associated Amyotrophic Lateral Sclerosis/Frontotemporal Dementia Open
Aggregating poly(glycine-alanine) (poly-GA) is derived from the unconventional translation of the pathogenic intronic hexanucleotide repeat expansion in the C9orf72 gene, which is the most common genetic cause of frontotemporal dementia (F…
View article: Inhibition of Canonical Transient Receptor Potential Channels 4/5 with Highly Selective and Potent Small-Molecule HC-070 Alleviates Mechanical Hypersensitivity in Rat Models of Visceral and Neuropathic Pain
Inhibition of Canonical Transient Receptor Potential Channels 4/5 with Highly Selective and Potent Small-Molecule HC-070 Alleviates Mechanical Hypersensitivity in Rat Models of Visceral and Neuropathic Pain Open
Transient receptor potential channels C4/C5 are widely expressed in the pain pathway. Here, we studied the putative analgesic efficacy of the highly selective and potent TRPC4/C5 antagonist HC-070 in rats. Inhibitory potency on human TRPC4…
View article: Pharmacokinetics of single and repeated oral doses of pregabalin oral solution formulation in cats
Pharmacokinetics of single and repeated oral doses of pregabalin oral solution formulation in cats Open
The study was designed to determine the pharmacokinetic profile and bioavailability of a novel pregabalin 50 mg/ml oral solution formulation (Bonqat ® , Orion Corporation Orion Pharma) in 6 healthy laboratory cats. The cats received pregab…
View article: GABA<sub>B</sub> receptor positive allosteric modulators with different efficacies affect neuroadaptation to and self‐administration of alcohol and cocaine
GABA<sub>B</sub> receptor positive allosteric modulators with different efficacies affect neuroadaptation to and self‐administration of alcohol and cocaine Open
Drugs of abuse induce widespread synaptic adaptations in the mesolimbic dopamine (DA) neurons. Such drug‐induced neuroadaptations may constitute an initial cellular mechanism eventually leading to compulsive drug‐seeking behavior. To evalu…