Janne Nieminen
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View article: <scp>HLA</scp>‐Region Genetic Association Analysis of Breast Cancer Patients With and Without Persistent Postsurgical Neuropathic Pain
<span>HLA</span>‐Region Genetic Association Analysis of Breast Cancer Patients With and Without Persistent Postsurgical Neuropathic Pain Open
Background Surgical nerve injuries lead to persistent neuropathic pain (NP) in up to 30% of patients. Among many other factors, polymorphisms in the human leukocyte antigen (HLA) genes have been suggested to contribute to the development o…
View article: Epstein-Barr Virus in the Cerebrospinal Fluid and Blood Compartments of Patients With Multiple Sclerosis and Controls
Epstein-Barr Virus in the Cerebrospinal Fluid and Blood Compartments of Patients With Multiple Sclerosis and Controls Open
EBV-DNA is equally detectable in the CSF cells of both patients with MS and controls with ddPCR, and the probabilistic approach indicates that the true positivity rate approaches 100% in EBV-positive individuals. The proportion of EBV-posi…
View article: Cultured lymphocytes’ mitochondrial genome integrity is not altered by cladribine
Cultured lymphocytes’ mitochondrial genome integrity is not altered by cladribine Open
Cladribine tablets are a treatment for multiple sclerosis with effects on lymphocytes, yet its mode of action has not been fully established. Here, we analyzed the effects of cladribine on mitochondrial DNA integrity in lymphocytes. We tre…
View article: Lymphocyte mitochondrial genome integrity is not altered by cladribine
Lymphocyte mitochondrial genome integrity is not altered by cladribine Open
Cladribine tablets are a treatment for multiple sclerosis (MS) with effects on lymphocytes’, yet its mode of action has not been fully established. Here, we evaluated the effects of cladribine on mitochondrial DNA integrity in human lympho…
View article: Immune response to a conserved enteroviral epitope of the major capsid VP1 protein is associated with lower risk of cardiovascular disease
Immune response to a conserved enteroviral epitope of the major capsid VP1 protein is associated with lower risk of cardiovascular disease Open
View article: Distribution of perfluoroalkyl acids in fish species from the Baltic Sea and freshwaters in Finland
Distribution of perfluoroalkyl acids in fish species from the Baltic Sea and freshwaters in Finland Open
Occurrence and distribution of perfluoroalkyl acids (PFAAs), a sub-category of per- and polyfluoroalkyl substances (PFASs), is widespread in the environment. Food, especially fish meat, is a major pathway via which humans are exposed to PF…
View article: Immunomodulatory Effects of Rhinovirus and Enterovirus Infections During the First Year of Life
Immunomodulatory Effects of Rhinovirus and Enterovirus Infections During the First Year of Life Open
Early childhood infections have been implicated in the development of immune-mediated diseases, such as allergies, asthma, and type 1 diabetes. We set out to investigate the immunomodulatory effects of early viral infections experienced be…
View article: Identification of two highly antigenic epitope markers predicting multiple sclerosis in optic neuritis patients
Identification of two highly antigenic epitope markers predicting multiple sclerosis in optic neuritis patients Open
View article: Food composition data and labelling – A challenging dialogue
Food composition data and labelling – A challenging dialogue Open
This report describes the activities of two projects that were carried out us-ing the infrastructure of the Nordic Food Analysis Network, i.e. the ‘Nordic Food Composition Data for Labelling (NordCoLa)’ project carried out between 2018 and…
View article: Maturation of Gut Microbiota and Circulating Regulatory T Cells and Development of IgE Sensitization in Early Life
Maturation of Gut Microbiota and Circulating Regulatory T Cells and Development of IgE Sensitization in Early Life Open
Recent studies suggest that the cross-talk between the gut microbiota and human immune system during the first year of life is an important regulator of the later development of atopic diseases. We explored the changes in the gut microbiot…
View article: Muutokset kotimaisen luonnonkalan ympäristömyrkkypitoisuuksissa (EU-kalat III)
Muutokset kotimaisen luonnonkalan ympäristömyrkkypitoisuuksissa (EU-kalat III) Open
Lisäksi kalvosarja (25 s., pdf), jossa esitelty Valtioneuvoston rahoittaman hankkeen EU-kalat III keskeisimmät tulokset tiiviisti.
View article: Exploring the risk factors for differences in the cumulative incidence of coeliac disease in two neighboring countries: the prospective DIABIMMUNE study
Exploring the risk factors for differences in the cumulative incidence of coeliac disease in two neighboring countries: the prospective DIABIMMUNE study Open
View article: Circulating Dendritic Cells, Farm Exposure and Asthma at Early Age
Circulating Dendritic Cells, Farm Exposure and Asthma at Early Age Open
Farm environment has been shown to protect from childhood asthma. Underlying immunological mechanisms are not clear yet, including the role of dendritic cells ( DC s). The aim was to explore whether asthma and farm exposures are associated…
View article: Predisposition to Childhood Otitis Media and Genetic Polymorphisms within the Toll-Like Receptor 4 (TLR4) Locus
Predisposition to Childhood Otitis Media and Genetic Polymorphisms within the Toll-Like Receptor 4 (TLR4) Locus Open
The TLR4 gene locus, regulating the innate immune response, influences the genetic predisposition to childhood OM in a subpopulation of patients. Environmental factors likely modulate the genetic components contributing to the risk of OM.