Jannicke Irina Nesman
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View article: A new synthetic protectin D1 analog 3-oxa-PD1<sub>n-3 DPA</sub> reduces neuropathic pain and chronic itch in mice
A new synthetic protectin D1 analog 3-oxa-PD1<sub>n-3 DPA</sub> reduces neuropathic pain and chronic itch in mice Open
The novel protectin D1 analog 3-oxa-PD1n-3 DPA was synthesized. Nanogram amounts of this analog reduces neuropathic pain and chronic itch, and shows analgesic action in a mouse model of diabetic neuropathy.
View article: Synthetic, Biosynthetic and Biological Studies of Specialized Pro-resolving Mediators: Novel Leads in Drug Discovery
Synthetic, Biosynthetic and Biological Studies of Specialized Pro-resolving Mediators: Novel Leads in Drug Discovery Open
Ny forskning har vist at omega-3 fettsyrer, som eikosapentaensyre (EPA), dokosapentaensyre (DPA), og dokosaheksaensyre (DHA), er viktige forløpere til hydroksylerte endogene forbindelser, som dannes i mennesker og dyr. En rekke biologiske …
View article: Stereoselective synthesis of the specialized pro-resolving and anti-inflammatory mediator resolvin E1
Stereoselective synthesis of the specialized pro-resolving and anti-inflammatory mediator resolvin E1 Open
The n-3 polyunsaturated fatty acids eicosapentaenoic acid, docosahexaenoic acid and n-3 docosapentaenoic acid, act as substrates for the biosynthesis of specialized pro-resolving lipid mediators. Resolvin E1, produced from eicosapentaenoic…
View article: Synthesis, Structural Confirmation, and Biosynthesis of 22-OH-PD1n-3 DPA
Synthesis, Structural Confirmation, and Biosynthesis of 22-OH-PD1n-3 DPA Open
PD1n-3 DPA belongs to the protectin family of specialized pro-resolving lipid mediators. The protectins are endogenously formed mediators that display potent anti-inflammatory properties and pro-resolving bioactivities and have attracted i…
View article: CCDC 1865776: Experimental Crystal Structure Determination
CCDC 1865776: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Synthetic studies towards one isomer of (-)-mucosin
Synthetic studies towards one isomer of (-)-mucosin Open
Denne oppgaven beskriver et forsøk på syntese av en isomer av (-)-mucosin, et bisyklisk naturprodukt isolert fra en marin svamp. Hovedfokuset i oppgaven var å utvikle en enantioselektiv totalsyntese basert på den foreslåtte strukturen (1) …