Philip R. Jansen
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Polygenic Childhood Obesity: Integrating Genetics and Environment for Early Intervention Open
Background: Childhood obesity is a global health challenge driven by a complex interplay of genetic predispositions and environmental exposures. Genome-wide association studies (GWAS) have identified many obesity-associated loci, and polyg…
View article: Transcriptomic and Metabolomic Analyses in Monozygotic and Dizygotic Twins
Transcriptomic and Metabolomic Analyses in Monozygotic and Dizygotic Twins Open
Monozygotic (MZ) and dizygotic (DZ) twins are studied to understand genetic and environmental influences on complex traits, however the mechanisms behind twinning are not completely understood. (Epi)genomic studies identified SNPs associat…
The utility of obesity polygenic risk scores from research to clinical practice: A review Open
Summary Obesity represents a major public health emergency worldwide, and its etiology is shaped by a complex interplay of environmental and genetic factors. Over the last decade, polygenic risk scores (PRS) have emerged as a promising too…
View article: Genome-Wide Analyses of Vocabulary Size in Infancy and Toddlerhood: Associations With Attention-Deficit/Hyperactivity Disorder, Literacy, and Cognition-Related Traits
Genome-Wide Analyses of Vocabulary Size in Infancy and Toddlerhood: Associations With Attention-Deficit/Hyperactivity Disorder, Literacy, and Cognition-Related Traits Open
The genetic architecture of early-life vocabulary changes during development, shaping polygenic association patterns with later-life ADHD, literacy, and cognition-related traits.
Genetic Burden of <i>TNNI3K</i> in Diagnostic Testing of Patients With Dilated Cardiomyopathy and Supraventricular Arrhythmias Open
BACKGROUND: Genetic variants in TNNI3K (troponin-I interacting kinase) have previously been associated with dilated cardiomyopathy (DCM), cardiac conduction disease, and supraventricular tachycardias. However, the link between TNNI3K varia…
View article: Genome-wide analyses of individual differences in quantitatively assessed reading- and language-related skills in up to 34,000 people
Genome-wide analyses of individual differences in quantitatively assessed reading- and language-related skills in up to 34,000 people Open
The use of spoken and written language is a fundamental human capacity. Individual differences in reading- and language-related skills are influenced by genetic variation, with twin-based heritability estimates of 30 to 80% depending on th…
View article: Genome-wide analyses of vocabulary size in infancy and toddlerhood: associations with Attention-Deficit/Hyperactivity Disorder and cognition-related traits
Genome-wide analyses of vocabulary size in infancy and toddlerhood: associations with Attention-Deficit/Hyperactivity Disorder and cognition-related traits Open
Background The number of words children produce (expressive vocabulary) and understand (receptive vocabulary) changes rapidly during early development, partially due to genetic factors, although mechanisms are not well understood. Here, we…
Exploring the genetic overlap between 12 psychiatric disorders Open
The widespread comorbidity among psychiatric disorders (PDs) demonstrated in epidemiological studies 1–5 is mirrored by non-zero, positive genetic correlations from large scale genetic studies 6–10 . We employed several strategies to uncov…
View article: Genome-wide association analyses of individual differences in quantitatively assessed reading- and language-related skills in up to 34,000 people
Genome-wide association analyses of individual differences in quantitatively assessed reading- and language-related skills in up to 34,000 people Open
The use of spoken and written language is a capacity that is unique to humans. Individual differences in reading- and language-related skills are influenced by genetic variation, with twin-based heritability estimates of 30-80%, depending …
Multivariate analysis reveals shared genetic architecture of brain morphology and human behavior. Open
Human variation in brain morphology and behavior are related and highly heritable. Yet, it is largely unknown to what extent specific features of brain morphology and behavior are genetically related. Here, we introduce a computationally e…
White matter microstructural differences in children and genetic risk for multiple sclerosis: A population-based study Open
Background: MS patients show abnormalities in white matter (WM) on brain imaging, with heterogeneity in the location of WM lesions. The “pothole” method can be applied to diffusion-weighted images to identify spatially distinct clusters of…
Brain morphology, autistic traits, and polygenic risk for autism: A p<span>opulation‐based</span>neuroimaging study Open
Autism spectrum disorders (ASD) are associated with widespread brain alterations. Previous research in our group linked autistic traits with altered gyrification, but without pronounced differences in cortical thickness. Herein, we aim to …