Janssen M. Kotah
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View article: Beyond the nuclear border: single-cell analysis of in situ sequenced human brain tissue using cellular features
Beyond the nuclear border: single-cell analysis of in situ sequenced human brain tissue using cellular features Open
Spatial transcriptomics has advanced our understanding of cellular heterogeneity at single-cell resolution. Here, we assess the suitability of in situ sequencing (ISS) for analyzing formalin-fixed, paraffin-embedded (FFPE) postmortem human…
View article: Microglial lipid phosphatase SHIP1 limits complement-mediated synaptic pruning in the healthy developing hippocampus
Microglial lipid phosphatase SHIP1 limits complement-mediated synaptic pruning in the healthy developing hippocampus Open
View article: Spatially resolved gene signatures of white matter lesion progression in multiple sclerosis
Spatially resolved gene signatures of white matter lesion progression in multiple sclerosis Open
View article: An anti-aging vaccine: BCG turns back the clock on remyelination failure
An anti-aging vaccine: BCG turns back the clock on remyelination failure Open
View article: Early‐life stress and amyloidosis in mice share pathogenic pathways involving synaptic mitochondria and lipid metabolism
Early‐life stress and amyloidosis in mice share pathogenic pathways involving synaptic mitochondria and lipid metabolism Open
INTRODUCTION Early‐life stress (ES) increases the risk for Alzheimer's disease (AD). We and others have shown that ES aggravates amyloid‐beta (Aβ) pathology and promotes cognitive dysfunction in APP/PS1 mice, but underlying mechanisms rema…
View article: Early-life stress exposure impacts the hippocampal synaptic proteome in a mouse model of Alzheimer’s disease: age- and pathology-dependent effects on mitochondrial proteins
Early-life stress exposure impacts the hippocampal synaptic proteome in a mouse model of Alzheimer’s disease: age- and pathology-dependent effects on mitochondrial proteins Open
Epidemiological evidence indicates that early life stress (ES) exposure increases the risk for later-life diseases, such as Alzheimer’s disease (AD). Accordingly, we and others have shown that ES aggravates the development of, and response…
View article: Early-life stress and early diet modulate the risk for Alzheimer’s disease: focus on microglia and polyunsaturated fatty acids in APP/PS1 mice
Early-life stress and early diet modulate the risk for Alzheimer’s disease: focus on microglia and polyunsaturated fatty acids in APP/PS1 mice Open
View article: Early-life stress lastingly impacts microglial transcriptome and function under basal and immune-challenged conditions
Early-life stress lastingly impacts microglial transcriptome and function under basal and immune-challenged conditions Open
View article: Early-life stress lastingly impacts microglial transcriptome and function under basal and immune-challenged conditions
Early-life stress lastingly impacts microglial transcriptome and function under basal and immune-challenged conditions Open
Early-life stress (ELS) leads to increased vulnerability to psychiatric disorders including depression later in life. Neuroinflammatory processes have been implicated in ELS-induced negative health outcomes, but how ELS impacts microglia, …
View article: Early-life stress lastingly impacts microglial transcriptome and function under basal and immune-challenged conditions
Early-life stress lastingly impacts microglial transcriptome and function under basal and immune-challenged conditions Open
Early-life stress (ELS) leads to increased vulnerability to psychiatric disorders including depression later in life. Neuroinflammatory processes have been implicated in ELS-induced negative health outcomes, but how ELS impacts microglia, …
View article: Sex-dependence and comorbidities of the early-life adversity induced mental and metabolic disease risks: Where are we at?
Sex-dependence and comorbidities of the early-life adversity induced mental and metabolic disease risks: Where are we at? Open
View article: Early-life brain lipids as a potential biomarker and target for intervention in Alzheimer’s disease
Early-life brain lipids as a potential biomarker and target for intervention in Alzheimer’s disease Open
View article: Early-life stress does not alter spatial memory performance, hippocampal neurogenesis, neuroinflammation, or telomere length in 20-month-old male mice
Early-life stress does not alter spatial memory performance, hippocampal neurogenesis, neuroinflammation, or telomere length in 20-month-old male mice Open
View article: Adult food choices depend on sex and exposure to early-life stress: Underlying brain circuitry, adipose tissue adaptations and metabolic responses
Adult food choices depend on sex and exposure to early-life stress: Underlying brain circuitry, adipose tissue adaptations and metabolic responses Open
View article: Characterization of astrocytes throughout life in wildtype and APP/PS1 mice after early-life stress exposure
Characterization of astrocytes throughout life in wildtype and APP/PS1 mice after early-life stress exposure Open
View article: Characterization of astrocytes throughout life in wildtype and APP/PS1 mice after early-life stress exposure
Characterization of astrocytes throughout life in wildtype and APP/PS1 mice after early-life stress exposure Open
Background Early-life stress (ES) is an emerging risk factor for later-life development of Alzheimer’s disease (AD). We have previously shown that ES modulates amyloid-beta pathology and the microglial response to it in the APPswe/PS1dE9 m…
View article: Characterization of astrocytes throughout life in wildtype and APP/PS1 mice after early-life stress exposure
Characterization of astrocytes throughout life in wildtype and APP/PS1 mice after early-life stress exposure Open
Background Early-life stress (ES) is an emerging risk factor for later-life development of Alzheimer’s disease (AD). We have previously shown that ES modulates amyloid-beta pathology and the microglial response to it in the APPswe/PS1dE9 m…
View article: Characterization of astrocytes throughout life in wildtype and APP/PS1 mice after early-life stress exposure
Characterization of astrocytes throughout life in wildtype and APP/PS1 mice after early-life stress exposure Open
Background Early-life stress (ES) is an emerging risk factor for later-life development of Alzheimer’s disease (AD). We have previously shown that ES modulates amyloid-beta pathology and the microglial response to it in the APPswe/PS1dE9 m…
View article: Early-Life Stress Does Not Aggravate Spatial Memory or the Process of Hippocampal Neurogenesis in Adult and Middle-Aged APP/PS1 Mice
Early-Life Stress Does Not Aggravate Spatial Memory or the Process of Hippocampal Neurogenesis in Adult and Middle-Aged APP/PS1 Mice Open
Life-time experiences are thought to influence the risk to develop the neurodegenerative disorder Alzheimer's disease (AD). In particular, early-life stress (ES) may modulate the onset and progression of AD. There is recent evidence by our…