Jared Block
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View article: Bone marrow Ki‐67 index is of prognostic value in newly diagnosed multiple myeloma
Bone marrow Ki‐67 index is of prognostic value in newly diagnosed multiple myeloma Open
Background Ki‐67 is an index of proliferative activity and is an established predictive and prognostic marker in multiple malignancies. However, its prognostic relevance in multiple myeloma (MM) is unclear. We investigated the relationship…
View article: Data from Diverse and Targetable Kinase Alterations Drive Histiocytic Neoplasms
Data from Diverse and Targetable Kinase Alterations Drive Histiocytic Neoplasms Open
Histiocytic neoplasms are clonal, hematopoietic disorders characterized by an accumulation of abnormal, monocyte-derived dendritic cells or macrophages in Langerhans cell histiocytosis (LCH) and non-Langerhans cell histiocytosis (non-LCH),…
View article: Supplementary Methods, Figures 1 - 5, Tables 1 - 5 from Diverse and Targetable Kinase Alterations Drive Histiocytic Neoplasms
Supplementary Methods, Figures 1 - 5, Tables 1 - 5 from Diverse and Targetable Kinase Alterations Drive Histiocytic Neoplasms Open
Supplementary Figure 1. Somatic mutations detected in histiocytic neoplasms. Supplementary Figure 2. Frequencies of known activating kinase mutations in histiocytic neoplasms. Supplementary Figure 3. ARAF mutations and variants of unknown …
View article: Data from Diverse and Targetable Kinase Alterations Drive Histiocytic Neoplasms
Data from Diverse and Targetable Kinase Alterations Drive Histiocytic Neoplasms Open
Histiocytic neoplasms are clonal, hematopoietic disorders characterized by an accumulation of abnormal, monocyte-derived dendritic cells or macrophages in Langerhans cell histiocytosis (LCH) and non-Langerhans cell histiocytosis (non-LCH),…
View article: Supplementary Methods, Figures 1 - 5, Tables 1 - 5 from Diverse and Targetable Kinase Alterations Drive Histiocytic Neoplasms
Supplementary Methods, Figures 1 - 5, Tables 1 - 5 from Diverse and Targetable Kinase Alterations Drive Histiocytic Neoplasms Open
Supplementary Figure 1. Somatic mutations detected in histiocytic neoplasms. Supplementary Figure 2. Frequencies of known activating kinase mutations in histiocytic neoplasms. Supplementary Figure 3. ARAF mutations and variants of unknown …
View article: <i>ALK</i>Fusions in a Wide Variety of Tumor Types Respond to Anti-ALK Targeted Therapy
<i>ALK</i>Fusions in a Wide Variety of Tumor Types Respond to Anti-ALK Targeted Therapy Open
Background Genomic fusions of the anaplastic lymphoma kinase gene (ALK) are a well-established therapy target in non-small cell lung cancer (NSCLC). From a survey of 114,200 clinical cases, we determined the prevalence of ALK rearrangement…
View article: Diverse and Targetable Kinase Alterations Drive Histiocytic Neoplasms
Diverse and Targetable Kinase Alterations Drive Histiocytic Neoplasms Open
Histiocytic neoplasms are clonal, hematopoietic disorders characterized by an accumulation of abnormal, monocyte-derived dendritic cells or macrophages in Langerhans cell histiocytosis (LCH) and non-Langerhans cell histiocytosis (non-LCH),…