Jared Odegard
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View article: Oral PD-L1 inhibitor GS-4224 selectively engages PD-L1 high cells and elicits pharmacodynamic responses in patients with advanced solid tumors
Oral PD-L1 inhibitor GS-4224 selectively engages PD-L1 high cells and elicits pharmacodynamic responses in patients with advanced solid tumors Open
Background Checkpoint inhibitors targeting the programmed cell death 1 (PD-1)/programmed cell death 1 ligand 1 (PD-L1) pathway are effective therapies in a range of immunogenic cancer types. Blocking this pathway with an oral therapy could…
View article: 515 CD47 expression is upregulated in solid tumors and correlates with phagocytic tumor-associated macrophage gene signature
515 CD47 expression is upregulated in solid tumors and correlates with phagocytic tumor-associated macrophage gene signature Open
Background Immune checkpoint blockade targeting the PD-1/PD-L1 axis has revolutionized the treatment of many solid tumors. PD-L1 expression is known to be modulated by both infiltrating T cells and by tumor intrinsic mechanisms. Therapeuti…
View article: A composite immune signature parallels disease progression across T1D subjects
A composite immune signature parallels disease progression across T1D subjects Open
At diagnosis, most people with type 1 diabetes (T1D) produce measurable levels of endogenous insulin, but the rate at which insulin secretion declines is heterogeneous. To explain this heterogeneity, we sought to identify a composite signa…
View article: Longitudinal monitoring of gene expression in ultra-low-volume blood samples self-collected at home
Longitudinal monitoring of gene expression in ultra-low-volume blood samples self-collected at home Open
Summary Blood transcriptional profiles could serve as biomarkers of clinical changes in subjects at-risk for or diagnosed with diabetes. However, transcriptional variation over time is poorly understood due to the impracticality of frequen…
View article: NETosis-associated serum biomarkers are reduced in type 1 diabetes in association with neutrophil count
NETosis-associated serum biomarkers are reduced in type 1 diabetes in association with neutrophil count Open
Summary As the immune pathways involved in the pathogenesis of type 1 diabetes (T1D) are not fully understood, biomarkers implicating novel mechanisms of disease are of great interest and call for independent evaluation. Recently, it was r…
View article: Virological and Preclinical Characterization of a Dendritic Cell Targeting, Integration-deficient Lentiviral Vector for Cancer Immunotherapy
Virological and Preclinical Characterization of a Dendritic Cell Targeting, Integration-deficient Lentiviral Vector for Cancer Immunotherapy Open
Dendritic cells (DCs) are essential antigen-presenting cells for the initiation of cytotoxic T-cell responses and therefore attractive targets for cancer immunotherapy. We have developed an integration-deficient lentiviral vector termed ID…
View article: Evaluation of Candidate Biomarkers of Type 1 Diabetes via the Core for Assay Validation
Evaluation of Candidate Biomarkers of Type 1 Diabetes via the Core for Assay Validation Open
Recognizing an increasing need for biomarkers that predict clinical outcomes in type 1 diabetes (T1D), JDRF, a major funding organization for T1D research, recently instituted the Core for Assay Validation (CAV) to accelerate the translati…