Jared Allan Sewell
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View article: Widespread variation in molecular interactions and regulatory properties among transcription factor isoforms
Widespread variation in molecular interactions and regulatory properties among transcription factor isoforms Open
Summary Most human Transcription factors (TFs) genes encode multiple protein isoforms differing in DNA binding domains, effector domains, or other protein regions. The global extent to which this results in functional differences between i…
View article: 392 Engineering CD70-directed CAR-NK cells for the treatment of hematological and solid malignancies
392 Engineering CD70-directed CAR-NK cells for the treatment of hematological and solid malignancies Open
Background While effective, CAR-T therapies are limited by a lack of scalability for patient-derived starting material. Alternatively, allogeneic CAR-NK cell therapies have the potential to overcome these limitations by providing an off-th…
View article: A functional screen identifies transcriptional networks that regulate HIV-1 and HIV-2
A functional screen identifies transcriptional networks that regulate HIV-1 and HIV-2 Open
Significance Understanding mechanisms that control HIV expression will provide insight into HIV replication, latency, and pathogenesis. In particular, HIV latency, which is a major barrier to a cure, is maintained by combinatorial mechanis…
View article: Comprehensive mapping of the human cytokine gene regulatory network
Comprehensive mapping of the human cytokine gene regulatory network Open
Proper cytokine gene expression is essential in development, homeostasis and immune responses. Studies on the transcriptional control of cytokine genes have mostly focused on highly researched transcription factors (TFs) and cytokines, res…
View article: Discovering human transcription factor physical interactions with genetic variants, novel DNA motifs, and repetitive elements using enhanced yeast one-hybrid assays
Discovering human transcription factor physical interactions with genetic variants, novel DNA motifs, and repetitive elements using enhanced yeast one-hybrid assays Open
Identifying transcription factor (TF) binding to noncoding variants, uncharacterized DNA motifs, and repetitive genomic elements has been technically and computationally challenging. Current experimental methods, such as chromatin immunopr…
View article: Discovering human transcription factor interactions with genetic variants, novel DNA motifs, and repetitive elements using enhanced yeast one-hybrid assays
Discovering human transcription factor interactions with genetic variants, novel DNA motifs, and repetitive elements using enhanced yeast one-hybrid assays Open
Identifying transcription factor (TF) binding to noncoding variants, uncharacterized DNA motifs, and repetitive genomic elements has been technically and computationally challenging. Current experimental methods, such as chromatin immunopr…
View article: Global landscape of mouse and human cytokine transcriptional regulation
Global landscape of mouse and human cytokine transcriptional regulation Open
Cytokines are cell-to-cell signaling proteins that play a central role in immune development, pathogen responses, and diseases. Cytokines are highly regulated at the transcriptional level by combinations of transcription factors (TFs) that…
View article: Global landscape of mouse and human cytokine transcriptional regulation
Global landscape of mouse and human cytokine transcriptional regulation Open
Cytokines play a central role in immune development, pathogen responses, and diseases. Cytokines are highly regulated at the transcriptional level by combinations of transcription factors (TFs) that recruit cofactors and the transcriptiona…
View article: Identification of Single Nucleotide Non-coding Driver Mutations in Cancer
Identification of Single Nucleotide Non-coding Driver Mutations in Cancer Open
Recent whole-genome sequencing studies have identified millions of somatic variants present in tumor samples. Most of these variants reside in non-coding regions of the genome potentially affecting transcriptional and post-transcriptional …
View article: The Molecular Mechanisms Governing Shoot Stem Cell Maintenance and Organ Patterning by a Family of Transcription Factors in Arabidopsis thaliana
The Molecular Mechanisms Governing Shoot Stem Cell Maintenance and Organ Patterning by a Family of Transcription Factors in Arabidopsis thaliana Open
Genome duplication in eukaryotes and particularly in plant species has led to gene families with both redundant and specialized functions. How closely related transcription factor families compete to alter gene expression and ultimately ma…