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View article: Supplementary Figure 7 from Defining the Ovarian Cancer Precancerous Landscape through Modeling Fallopian Tube Epithelium Reprogramming Driven by Extracellular Vesicles
Supplementary Figure 7 from Defining the Ovarian Cancer Precancerous Landscape through Modeling Fallopian Tube Epithelium Reprogramming Driven by Extracellular Vesicles Open
EVs from OVCAR3 do not induce detectable DNA damage relative to controls in short term exposure.
View article: Supplementary Figure 15 from Defining the Ovarian Cancer Precancerous Landscape through Modeling Fallopian Tube Epithelium Reprogramming Driven by Extracellular Vesicles
Supplementary Figure 15 from Defining the Ovarian Cancer Precancerous Landscape through Modeling Fallopian Tube Epithelium Reprogramming Driven by Extracellular Vesicles Open
Key IFN-γ pathway genes are upregulated by OVCAR3 EV treatment.
View article: Supplementary Data File 3 from Defining the Ovarian Cancer Precancerous Landscape through Modeling Fallopian Tube Epithelium Reprogramming Driven by Extracellular Vesicles
Supplementary Data File 3 from Defining the Ovarian Cancer Precancerous Landscape through Modeling Fallopian Tube Epithelium Reprogramming Driven by Extracellular Vesicles Open
Comparison of expression in hFTE with different EV treatments.
View article: Figure 6 from Defining the Ovarian Cancer Precancerous Landscape through Modeling Fallopian Tube Epithelium Reprogramming Driven by Extracellular Vesicles
Figure 6 from Defining the Ovarian Cancer Precancerous Landscape through Modeling Fallopian Tube Epithelium Reprogramming Driven by Extracellular Vesicles Open
Fallopian tube alters sEVs protein cargo after treatment with OVCAR3 EVs for 14 days. A, Diagram showing EV treatment of hFTE tissue and production of secondary-release EVs. B, Volcano plot showing proteomic changes in EVs derived from tis…
View article: Supplementary Table 2 from Defining the Ovarian Cancer Precancerous Landscape through Modeling Fallopian Tube Epithelium Reprogramming Driven by Extracellular Vesicles
Supplementary Table 2 from Defining the Ovarian Cancer Precancerous Landscape through Modeling Fallopian Tube Epithelium Reprogramming Driven by Extracellular Vesicles Open
Segments collected using GeoMx DSP before and after quality control
View article: Supplementary Figure 11 from Defining the Ovarian Cancer Precancerous Landscape through Modeling Fallopian Tube Epithelium Reprogramming Driven by Extracellular Vesicles
Supplementary Figure 11 from Defining the Ovarian Cancer Precancerous Landscape through Modeling Fallopian Tube Epithelium Reprogramming Driven by Extracellular Vesicles Open
GO Biological pathways downregulated by FT240 EVs.
View article: Figure 1 from Defining the Ovarian Cancer Precancerous Landscape through Modeling Fallopian Tube Epithelium Reprogramming Driven by Extracellular Vesicles
Figure 1 from Defining the Ovarian Cancer Precancerous Landscape through Modeling Fallopian Tube Epithelium Reprogramming Driven by Extracellular Vesicles Open
Experimental design and characterization of PREDICT-MOS–cultured FTE. A, Diagram showing culture of hFTE and experimental setup including culture on platform (time course and exposures), EV purification, and proteomic and spatial transcrip…
View article: Supplementary Figure 8 from Defining the Ovarian Cancer Precancerous Landscape through Modeling Fallopian Tube Epithelium Reprogramming Driven by Extracellular Vesicles
Supplementary Figure 8 from Defining the Ovarian Cancer Precancerous Landscape through Modeling Fallopian Tube Epithelium Reprogramming Driven by Extracellular Vesicles Open
EVs from OVCAR3 do not induce detectable DNA damage relative to controls in long term exposure.
View article: Supplementary Figure 14 from Defining the Ovarian Cancer Precancerous Landscape through Modeling Fallopian Tube Epithelium Reprogramming Driven by Extracellular Vesicles
Supplementary Figure 14 from Defining the Ovarian Cancer Precancerous Landscape through Modeling Fallopian Tube Epithelium Reprogramming Driven by Extracellular Vesicles Open
Unsupervised clustering of Figure 5E.
View article: Supplementary Data File 1 from Defining the Ovarian Cancer Precancerous Landscape through Modeling Fallopian Tube Epithelium Reprogramming Driven by Extracellular Vesicles
Supplementary Data File 1 from Defining the Ovarian Cancer Precancerous Landscape through Modeling Fallopian Tube Epithelium Reprogramming Driven by Extracellular Vesicles Open
OVCAR3-FT240 EV Proteome Profile
View article: Supplementary Figure 16 from Defining the Ovarian Cancer Precancerous Landscape through Modeling Fallopian Tube Epithelium Reprogramming Driven by Extracellular Vesicles
Supplementary Figure 16 from Defining the Ovarian Cancer Precancerous Landscape through Modeling Fallopian Tube Epithelium Reprogramming Driven by Extracellular Vesicles Open
Transcripts upregulated by OVCAR3 EVs are also upregulated in progression from precursor lesion to invasive cancer.
View article: Supplementary Figure 3 from Defining the Ovarian Cancer Precancerous Landscape through Modeling Fallopian Tube Epithelium Reprogramming Driven by Extracellular Vesicles
Supplementary Figure 3 from Defining the Ovarian Cancer Precancerous Landscape through Modeling Fallopian Tube Epithelium Reprogramming Driven by Extracellular Vesicles Open
Uncropped western blot images.
View article: Figure 5 from Defining the Ovarian Cancer Precancerous Landscape through Modeling Fallopian Tube Epithelium Reprogramming Driven by Extracellular Vesicles
Figure 5 from Defining the Ovarian Cancer Precancerous Landscape through Modeling Fallopian Tube Epithelium Reprogramming Driven by Extracellular Vesicles Open
EV treatment with ovarian cancer EVs induced immune responsive and chemokine signaling pathways. A and B, GO analysis showing pathways upregulated (B) and downregulated (C) by OVCAR3 EVs in secretory cells. C and D, GO analysis showing (C)…
View article: Figure 4 from Defining the Ovarian Cancer Precancerous Landscape through Modeling Fallopian Tube Epithelium Reprogramming Driven by Extracellular Vesicles
Figure 4 from Defining the Ovarian Cancer Precancerous Landscape through Modeling Fallopian Tube Epithelium Reprogramming Driven by Extracellular Vesicles Open
Transcriptomics analysis of hFTE after long-term EV exposure (14 days). A and B, Volcano plots showing differentially expressed transcripts in secretory cells in (A) OVCAR3 EV–treated and (B) FT240 EV–treated hFTE compared with PBS control…
View article: Figure 2 from Defining the Ovarian Cancer Precancerous Landscape through Modeling Fallopian Tube Epithelium Reprogramming Driven by Extracellular Vesicles
Figure 2 from Defining the Ovarian Cancer Precancerous Landscape through Modeling Fallopian Tube Epithelium Reprogramming Driven by Extracellular Vesicles Open
Purified EV characterization and confirmation of sEV uptake in tissue. A and B, transmission electron micrograph of sEVs from OVCAR3 (A) and FT240 (B) cells under 30,000× magnification. C, Western blots comparing the expression of sEV mark…
View article: Supplementary Methods from Defining the Ovarian Cancer Precancerous Landscape through Modeling Fallopian Tube Epithelium Reprogramming Driven by Extracellular Vesicles
Supplementary Methods from Defining the Ovarian Cancer Precancerous Landscape through Modeling Fallopian Tube Epithelium Reprogramming Driven by Extracellular Vesicles Open
Supplementary Methods
View article: Supplementary Figure 9 from Defining the Ovarian Cancer Precancerous Landscape through Modeling Fallopian Tube Epithelium Reprogramming Driven by Extracellular Vesicles
Supplementary Figure 9 from Defining the Ovarian Cancer Precancerous Landscape through Modeling Fallopian Tube Epithelium Reprogramming Driven by Extracellular Vesicles Open
PAX2 expression is downregulated by OVCAR3 EVs
View article: Supplementary Figure 10 from Defining the Ovarian Cancer Precancerous Landscape through Modeling Fallopian Tube Epithelium Reprogramming Driven by Extracellular Vesicles
Supplementary Figure 10 from Defining the Ovarian Cancer Precancerous Landscape through Modeling Fallopian Tube Epithelium Reprogramming Driven by Extracellular Vesicles Open
GO Biological pathways upregulated by FT240 EVs.
View article: Supplementary Figure 5 from Defining the Ovarian Cancer Precancerous Landscape through Modeling Fallopian Tube Epithelium Reprogramming Driven by Extracellular Vesicles
Supplementary Figure 5 from Defining the Ovarian Cancer Precancerous Landscape through Modeling Fallopian Tube Epithelium Reprogramming Driven by Extracellular Vesicles Open
Measurement of CCL2 production in cell line models of the fallopian tube shows no significant differences following EV exposure.
View article: Figure 3 from Defining the Ovarian Cancer Precancerous Landscape through Modeling Fallopian Tube Epithelium Reprogramming Driven by Extracellular Vesicles
Figure 3 from Defining the Ovarian Cancer Precancerous Landscape through Modeling Fallopian Tube Epithelium Reprogramming Driven by Extracellular Vesicles Open
Transcriptomics analysis of hFTE after short-term EV exposure (1 day). A and B, Volcano plots showing differentially expressed transcripts in secretory cells in (A) OVCAR3 EV–treated and (B) FT240 EV–treated hFTE compared with PBS controls…
View article: Supplementary Data File 2 from Defining the Ovarian Cancer Precancerous Landscape through Modeling Fallopian Tube Epithelium Reprogramming Driven by Extracellular Vesicles
Supplementary Data File 2 from Defining the Ovarian Cancer Precancerous Landscape through Modeling Fallopian Tube Epithelium Reprogramming Driven by Extracellular Vesicles Open
Transcript expression in ciliated vs secretory cells.
View article: Supplementary Figure 6 from Defining the Ovarian Cancer Precancerous Landscape through Modeling Fallopian Tube Epithelium Reprogramming Driven by Extracellular Vesicles
Supplementary Figure 6 from Defining the Ovarian Cancer Precancerous Landscape through Modeling Fallopian Tube Epithelium Reprogramming Driven by Extracellular Vesicles Open
qPCR analysis shows inconsistent responses in FT cell line models to OVCAR3 EV stimulation.
View article: Figure 7 from Defining the Ovarian Cancer Precancerous Landscape through Modeling Fallopian Tube Epithelium Reprogramming Driven by Extracellular Vesicles
Figure 7 from Defining the Ovarian Cancer Precancerous Landscape through Modeling Fallopian Tube Epithelium Reprogramming Driven by Extracellular Vesicles Open
Validation of 1-day and 14-day treatment transcriptomics data using IHC. A, Left, CCL2 transcript expression in OVCAR3-, FT240-, and PBS-treated secretory cells after 1 day. Right, IHC staining for upregulated CCL2 in FTE from three indivi…
View article: Supplementary Data File 4 from Defining the Ovarian Cancer Precancerous Landscape through Modeling Fallopian Tube Epithelium Reprogramming Driven by Extracellular Vesicles
Supplementary Data File 4 from Defining the Ovarian Cancer Precancerous Landscape through Modeling Fallopian Tube Epithelium Reprogramming Driven by Extracellular Vesicles Open
Differential protein expression in hFTE derived eVs.
View article: Data from Defining the Ovarian Cancer Precancerous Landscape through Modeling Fallopian Tube Epithelium Reprogramming Driven by Extracellular Vesicles
Data from Defining the Ovarian Cancer Precancerous Landscape through Modeling Fallopian Tube Epithelium Reprogramming Driven by Extracellular Vesicles Open
Serous tubal intraepithelial carcinomas (lesions) in the human fallopian tube epithelium (hFTE) are theorized to give rise to high-grade serous ovarian cancers. Small extracellular vesicles (sEV) are known to mediate key signaling in both …
View article: Supplementary Figure 1 from Defining the Ovarian Cancer Precancerous Landscape through Modeling Fallopian Tube Epithelium Reprogramming Driven by Extracellular Vesicles
Supplementary Figure 1 from Defining the Ovarian Cancer Precancerous Landscape through Modeling Fallopian Tube Epithelium Reprogramming Driven by Extracellular Vesicles Open
EV proteome comparison and yield analysis.
View article: Supplementary Figure 4 from Defining the Ovarian Cancer Precancerous Landscape through Modeling Fallopian Tube Epithelium Reprogramming Driven by Extracellular Vesicles
Supplementary Figure 4 from Defining the Ovarian Cancer Precancerous Landscape through Modeling Fallopian Tube Epithelium Reprogramming Driven by Extracellular Vesicles Open
Validation of segmentation of ciliated and secretory segments in short-term and long-term culture.
View article: Supplementary Figure 13 from Defining the Ovarian Cancer Precancerous Landscape through Modeling Fallopian Tube Epithelium Reprogramming Driven by Extracellular Vesicles
Supplementary Figure 13 from Defining the Ovarian Cancer Precancerous Landscape through Modeling Fallopian Tube Epithelium Reprogramming Driven by Extracellular Vesicles Open
Kegg and reactome pathways upregulated and downregulated by FT240 EVs.
View article: Supplementary Figure 12 from Defining the Ovarian Cancer Precancerous Landscape through Modeling Fallopian Tube Epithelium Reprogramming Driven by Extracellular Vesicles
Supplementary Figure 12 from Defining the Ovarian Cancer Precancerous Landscape through Modeling Fallopian Tube Epithelium Reprogramming Driven by Extracellular Vesicles Open
KEGG and reactome pathways upregulated and downregulated by OVCAR3 EVs.
View article: Supplementary Figure 2 from Defining the Ovarian Cancer Precancerous Landscape through Modeling Fallopian Tube Epithelium Reprogramming Driven by Extracellular Vesicles
Supplementary Figure 2 from Defining the Ovarian Cancer Precancerous Landscape through Modeling Fallopian Tube Epithelium Reprogramming Driven by Extracellular Vesicles Open
GeoMx DSP quality control analysis.