Jared V. Balbona
YOU?
Author Swipe
View article: Multi-ancestral genome-wide study of chronic pain reveals widespread genetic correlations with mental and physical health traits
Multi-ancestral genome-wide study of chronic pain reveals widespread genetic correlations with mental and physical health traits Open
Chronic pain (CP) is a debilitating condition that impacts an individual’s physical and mental health. CP is common, affecting around 12-40% of individuals across the world. In this study, we conducted a genome-wide association study (GWAS…
View article: Leveraging Genomic Data to Examine the Causal Impact of Alcohol, Tobacco, Cannabis, and Opioid Use on Biological and Cognitive Ageing
Leveraging Genomic Data to Examine the Causal Impact of Alcohol, Tobacco, Cannabis, and Opioid Use on Biological and Cognitive Ageing Open
Although substance use is associated with a shortened lifespan, impeded health and accelerated biological ageing, the factors contributing to the associations between substance use and ageing are poorly understood. We used summary statisti…
View article: Multi-ancestral genome-wide association study of clinically defined nicotine dependence reveals strong genetic correlations with other substance use disorders and health-related traits
Multi-ancestral genome-wide association study of clinically defined nicotine dependence reveals strong genetic correlations with other substance use disorders and health-related traits Open
Genetic research on nicotine dependence has utilized multiple assessments that are in weak agreement. We conducted a genome-wide association study of nicotine dependence defined using the Diagnostic and Statistical Manual of Mental Disorde…
View article: Multi-ancestral genome-wide association study of clinically defined nicotine dependence reveals strong genetic correlations with other substance use disorders and health-related traits
Multi-ancestral genome-wide association study of clinically defined nicotine dependence reveals strong genetic correlations with other substance use disorders and health-related traits Open
Background Genetic research on nicotine dependence has utilized multiple assessments that are in weak agreement. Methods We conducted a genome-wide association study (GWAS) of nicotine dependence defined using the Diagnostic and Statistica…
View article: Associations between prenatal caffeine exposure and child development: Longitudinal results from the Adolescent Brain Cognitive Development (ABCD) Study
Associations between prenatal caffeine exposure and child development: Longitudinal results from the Adolescent Brain Cognitive Development (ABCD) Study Open
View article: Examining the causal genetic effects of substance use on aging
Examining the causal genetic effects of substance use on aging Open
Substance use shortens lifespan, impedes health, and accelerates the biological aging process. We found widespread genetic correlations between alcohol, tobacco, cannabis, and opioid use and use disorders with indices of aging across the l…
View article: Associations between prenatal caffeine exposure and child development: Longitudinal results from the Adolescent Brain Cognitive Development (ABCD) Study
Associations between prenatal caffeine exposure and child development: Longitudinal results from the Adolescent Brain Cognitive Development (ABCD) Study Open
Objective Though caffeine use during pregnancy is common, its longitudinal associations with child behavioral and physical health outcomes remain poorly understood. Here, we estimated associations between prenatal caffeine exposure, body m…
View article: Evidence of correlations between human partners based on systematic reviews and meta-analyses of 22 traits and UK Biobank analysis of 133 traits
Evidence of correlations between human partners based on systematic reviews and meta-analyses of 22 traits and UK Biobank analysis of 133 traits Open
View article: The estimation of environmental and genetic parental influences
The estimation of environmental and genetic parental influences Open
Parents share half of their genes with their children, but they also share background social factors and actively help shape their child’s environment – making it difficult to disentangle genetic and environmental causes of parent–offsprin…
View article: Within-sibship genome-wide association analyses decrease bias in estimates of direct genetic effects
Within-sibship genome-wide association analyses decrease bias in estimates of direct genetic effects Open
View article: Correlations between human mating partners: a comprehensive meta-analysis of 22 traits and raw data analysis of 133 traits in the UK Biobank
Correlations between human mating partners: a comprehensive meta-analysis of 22 traits and raw data analysis of 133 traits in the UK Biobank Open
Positive correlations between human mating partners are consistently observed across traits. Such correlations can increase phenotypic variation and, to the extent that they reflect genetic similarity in co-parents, can also increase preva…
View article: Within-sibship GWAS improve estimates of direct genetic effects
Within-sibship GWAS improve estimates of direct genetic effects Open
Estimates from genome-wide association studies (GWAS) represent a combination of the effect of inherited genetic variation (direct effects), demography (population stratification, assortative mating) and genetic nurture from relatives (ind…
View article: Neuroticism and reward-related ventral striatum activity: Probing vulnerability to stress-related depression.
Neuroticism and reward-related ventral striatum activity: Probing vulnerability to stress-related depression. Open
Elevated neuroticism may confer vulnerability to the depressogenic effects of stressful life events (SLEs). However, the mechanisms underlying this susceptibility remain poorly understood. Accumulating evidence suggests that stress-related…
View article: Estimation of Parental Effects Using Polygenic Scores
Estimation of Parental Effects Using Polygenic Scores Open
Offspring resemble their parents for both genetic and environmental reasons. Understanding the relative magnitude of these alternatives has long been a core interest in behavioral genetics research, but traditional designs, which compare p…
View article: Bias and Precision of Parameter Estimates from Models Using Polygenic Scores to Estimate Environmental and Genetic Parental Influences
Bias and Precision of Parameter Estimates from Models Using Polygenic Scores to Estimate Environmental and Genetic Parental Influences Open
In a companion paper Balbona et al. (Behav Genet, in press), we introduced a series of causal models that use polygenic scores from transmitted and nontransmitted alleles, the offspring trait, and parental traits to estimate the variation …
View article: Estimation of parental effects using polygenic scores
Estimation of parental effects using polygenic scores Open
Offspring resemble their parents for both genetic and environmental reasons. Understanding the relative magnitude of these alternatives has long been a core interest in behavioral genetics research, but traditional designs, which compare p…
View article: Bias and precision of parameter estimates from models using polygenic scores to estimate environmental and genetic parental influences
Bias and precision of parameter estimates from models using polygenic scores to estimate environmental and genetic parental influences Open
In a companion paper (Balbona et al. (2020)), we introduced a series of causal models that use polygenic scores from transmitted and nontransmitted alleles, the offspring trait, and parental traits to estimate the variation due to the envi…
View article: Neuroticism and reward-related ventral striatum activity: Probing vulnerability to stress-related depression
Neuroticism and reward-related ventral striatum activity: Probing vulnerability to stress-related depression Open
Background: Elevated neuroticism may confer vulnerability to the depressogenic effects of stressful life events (SLEs). Vulnerability to stress-related disruption of neural reward processing is a promising neural mechanism undergirding lin…
View article: The crude ostracism detection system: Pupils react to minimal cues of exclusion
The crude ostracism detection system: Pupils react to minimal cues of exclusion Open
When people are rejected by others, they typically feel an immediate sense of pain – referred to as social pain. Social pain is hypothesized to be the alarm response of a “quick and crude” ostracism detection system, a system that is highl…
View article: Neuroticism as a Moderator of the Depressogenic Effects of Stress: Examining the Role of Neural Reward Processing
Neuroticism as a Moderator of the Depressogenic Effects of Stress: Examining the Role of Neural Reward Processing Open
From the Washington University Senior Honors Thesis Abstracts (WUSHTA), Spring 2018. Published by the Office of Undergraduate Research. Joy Zalis Kiefer, Director of Undergraduate Research and Associate Dean in the College of Arts & Scienc…
View article: Pupillometric Response to Implicit Social Exclusion
Pupillometric Response to Implicit Social Exclusion Open
Previous research suggests that people are highly sensitive to rejection, and may even display physiological reactions, such as increased pupil dilation, when they are explicitly rejected by others compared to when they are accepted (Silk …
View article: Studying Implicit Social Exclusion Using Pupillometric Analysis
Studying Implicit Social Exclusion Using Pupillometric Analysis Open
From the Washington University Office of Undergraduate Research Digest (WUURD), Vol. 12, 05-01-2017. Published by the Office of Undergraduate Research. Joy Zalis Kiefer, Director of Undergraduate Research and Associate Dean in the College …