Jar-How Lee
YOU?
Author Swipe
View article: Antigen quantity is responsible for the discrepancy between phenotype and single antigen beads for the detection of human leukocyte antigen DQ antibody: Potential clinical implications
Antigen quantity is responsible for the discrepancy between phenotype and single antigen beads for the detection of human leukocyte antigen DQ antibody: Potential clinical implications Open
De novo donor-specific human leukocyte antigen DQ antibodies detected by single antigen beads (SAB) are significantly associated with chronic antibody-mediated rejection and lower overall graft survival. However, some DQ antibodies identif…
View article: Characterisation of the <scp>HLA</scp>‐<scp>DQ</scp> alpha eplet <scp>52SK</scp> targeting the <scp><i>DQA1*01</i></scp> alleles family
Characterisation of the <span>HLA</span>‐<span>DQ</span> alpha eplet <span>52SK</span> targeting the <span><i>DQA1*01</i></span> alleles family Open
Eplet 52SK is unique in the HLA eplet registry as targeting the whole family of DQA1*01 alleles. It is proposed as an antibody‐verified eplet but has not been validated enough to deserve this label. Especially, confusion can occur with rea…
View article: HLA class I peptide polymorphisms contribute to class II DQβ0603:DQα0103 antibody specificity
HLA class I peptide polymorphisms contribute to class II DQβ0603:DQα0103 antibody specificity Open
Antibodies reactive to human leukocyte antigens (HLA) represent a barrier for patients awaiting transplantation. Based on reactivity patterns in single-antigen bead (SAB) assays, various epitope matching algorithms have been proposed to im…
View article: Multicenter Validation of a Urine CXCL10 Assay for Noninvasive Monitoring of Renal Transplants
Multicenter Validation of a Urine CXCL10 Assay for Noninvasive Monitoring of Renal Transplants Open
Background. Urine CXCL10 (C-X-C motif chemokine ligand 10, interferon gamma-induced protein 10 [IP10]) outperforms standard-of-care monitoring for detecting subclinical and early clinical T-cell–mediated rejection (TCMR) and may advance TC…
View article: Differences in Humoral and Cellular Vaccine Responses to SARS-CoV-2 in Kidney and Liver Transplant Recipients
Differences in Humoral and Cellular Vaccine Responses to SARS-CoV-2 in Kidney and Liver Transplant Recipients Open
The antibody and T cell responses after SARS-CoV-2 vaccination have not been formally compared between kidney and liver transplant recipients. Using a multiplex assay, we measured IgG levels against 4 epitopes of SARS-CoV-2 spike protein a…
View article: Development and validation of a multiplex bead based assay for the detection of antibodies directed against SARS-CoV-2 proteins
Development and validation of a multiplex bead based assay for the detection of antibodies directed against SARS-CoV-2 proteins Open
Transplant recipients who develop COVID-19 may be at increased risk for morbidity and mortality. Determining antibody status against SARS-CoV-2 in candidates and recipients will be important to understand the epidemiology and clinical cour…
View article: Reassessment of the clinical impact of preformed donor-specific anti-HLA-Cw antibodies in kidney transplantation
Reassessment of the clinical impact of preformed donor-specific anti-HLA-Cw antibodies in kidney transplantation Open
Anti-denatured HLA-Cw antibodies are highly prevalent, whereas anti-native HLA-Cw antibodies seem to lead to random flow cytometry crossmatch results. We aimed to reassess crossmatch prediction for anti-HLA-Cw using 2 types of single antig…
View article: Mapping molecular HLA typing data to UNOS antigen equivalents
Mapping molecular HLA typing data to UNOS antigen equivalents Open
Computer-assisted interpretation of molecular HLA data may aid in reducing typing discrepancies in UNet. This work also sets a foundation for molecular typing data to be utilized directly in the UNet match run as well as the virtual crossm…
View article: Mapping molecular HLA typing data to UNOS antigen equivalents for improved virtual crossmatch
Mapping molecular HLA typing data to UNOS antigen equivalents for improved virtual crossmatch Open
Background Virtual crossmatch utilizes HLA typing and antibody screen assay data as a part of organ offers in deceased donor allocation systems. Histocompatibility labs must convert molecular HLA typings to antigen equivalencies for entry …