Jarmo T. Laitinen
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View article: Rapid elimination of suprachoroidally injected small molecule drugs into the systemic blood circulation
Rapid elimination of suprachoroidally injected small molecule drugs into the systemic blood circulation Open
View article: Novel in vitro model for intravitreal drug dissolution and release studies of small molecules and their long-acting formulations
Novel in vitro model for intravitreal drug dissolution and release studies of small molecules and their long-acting formulations Open
Intravitreal drug delivery is essential for multiple ocular diseases. Development of intravitreal formulations requires high-quality in vivo experiments that require a large number of animals. This development can be expedited by improving…
View article: Talousmetsien luonnonhoidon kehitys vuosina 1995‒2018 luonnonhoidon laadun arvioinnin sekä valtakunnan metsien inventoinnin tulosten perusteella
Talousmetsien luonnonhoidon kehitys vuosina 1995‒2018 luonnonhoidon laadun arvioinnin sekä valtakunnan metsien inventoinnin tulosten perusteella Open
Talousmetsien luonnonhoidon laatua on arvioitu vuodesta 1995 lähtien. Yksityismailla on arvioitu vuosittain keskimäärin noin 750 leimikkoa (vaihteluväli 350–1000 leimikkoa), joiden yhteispinta-ala on noin 2500 hehtaaria (1100–3900 ha). Tar…
View article: High-Resolution Confocal Fluorescence Imaging of Serine Hydrolase Activity in Cryosections – Application to Glioma Brain Unveils Activity Hotspots Originating from Tumor-Associated Neutrophils
High-Resolution Confocal Fluorescence Imaging of Serine Hydrolase Activity in Cryosections – Application to Glioma Brain Unveils Activity Hotspots Originating from Tumor-Associated Neutrophils Open
View article: Soiden eliölajit ja niiden uhanalaisuus
Soiden eliölajit ja niiden uhanalaisuus Open
View article: Additional file 3 of High-Resolution Confocal Fluorescence Imaging of Serine Hydrolase Activity in Cryosections – Application to Glioma Brain Unveils Activity Hotspots Originating from Tumor-Associated Neutrophils
Additional file 3 of High-Resolution Confocal Fluorescence Imaging of Serine Hydrolase Activity in Cryosections – Application to Glioma Brain Unveils Activity Hotspots Originating from Tumor-Associated Neutrophils Open
Additional file 3. Complete LC-MS/MS data of all proteins identified from the ABPP gel-pieces.
View article: Tissue-ABPP enables high-resolution confocal fluorescence imaging of serine hydrolase activity in cryosections – Application to glioma brain unveils activity hotspots originating from tumor-associated neutrophils
Tissue-ABPP enables high-resolution confocal fluorescence imaging of serine hydrolase activity in cryosections – Application to glioma brain unveils activity hotspots originating from tumor-associated neutrophils Open
Serine hydrolases (SHs) are a functionally diverse family of enzymes playing pivotal roles in health and disease and have emerged as important therapeutic targets in many clinical conditions. Activity-based protein profiling (ABPP) using f…
View article: Mire margin to expanse gradient in part relates to nutrients gradient: evidence from successional mire basins, north Finland
Mire margin to expanse gradient in part relates to nutrients gradient: evidence from successional mire basins, north Finland Open
To study the relationship between mire vegetation and ecological variables we tested the Finnish hypothesis that the mire margin to expanse gradient in vegetation composition relates to a gradient of solutes (main plant nutrients) in the s…
View article: Discovery of 12-Thiazole Abietanes as Selective Inhibitors of the Human Metabolic Serine Hydrolase hABHD16A
Discovery of 12-Thiazole Abietanes as Selective Inhibitors of the Human Metabolic Serine Hydrolase hABHD16A Open
Screening of an in-house library of compounds identified 12-thiazole abietanes as a new class of reversible inhibitors of the human metabolic serine hydrolase. Further optimization of the first hit compound lead to the 2-methylthiazole der…
View article: CCDC 1526903: Experimental Crystal Structure Determination
CCDC 1526903: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1526901: Experimental Crystal Structure Determination
CCDC 1526901: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1526900: Experimental Crystal Structure Determination
CCDC 1526900: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Synthesis and preclinical evaluation of [ 11 C]MA-PB-1 for in vivo imaging of brain monoacylglycerol lipase (MAGL)
Synthesis and preclinical evaluation of [ 11 C]MA-PB-1 for in vivo imaging of brain monoacylglycerol lipase (MAGL) Open
View article: CCDC 1526902: Experimental Crystal Structure Determination
CCDC 1526902: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: In Vivo Characterization of the Ultrapotent Monoacylglycerol Lipase Inhibitor {4-[bis-(benzo[d][1,3]dioxol-5-yl)methyl]-piperidin-1-yl}(1H-1,2,4-triazol-1-yl)methanone (JJKK-048)
In Vivo Characterization of the Ultrapotent Monoacylglycerol Lipase Inhibitor {4-[bis-(benzo[d][1,3]dioxol-5-yl)methyl]-piperidin-1-yl}(1H-1,2,4-triazol-1-yl)methanone (JJKK-048) Open
View article: Ecological, topographic and successional patterns across wetlands in a rugged land uplift coast in Nyby, northern Finland
Ecological, topographic and successional patterns across wetlands in a rugged land uplift coast in Nyby, northern Finland Open
We studied 45 mid-boreal wetlands in a rugged land uplift coast with a thin cover of till. Wetlands ranged from 1 to 53 m a.s.l. and were of highly various sizes. Our aims were to examine, if vegetation types are valid in comparing wetland…
View article: Potent and selective N-(4-sulfamoylphenyl)thiourea-based GPR55 agonists
Potent and selective N-(4-sulfamoylphenyl)thiourea-based GPR55 agonists Open
View article: Revisiting 1,3,4-Oxadiazol-2-ones: Utilization in the Development of ABHD6 Inhibitors
Revisiting 1,3,4-Oxadiazol-2-ones: Utilization in the Development of ABHD6 Inhibitors Open
View article: Increased tonic cannabinoid CB1R activity and brain region-specific desensitization of CB1R Gi/o signaling axis in mice with global genetic knockout of monoacylglycerol lipase
Increased tonic cannabinoid CB1R activity and brain region-specific desensitization of CB1R Gi/o signaling axis in mice with global genetic knockout of monoacylglycerol lipase Open
View article: Loratadine analogues as MAGL inhibitors
Loratadine analogues as MAGL inhibitors Open
View article: Vascular plant and moss species across successional mire basins on the land uplift coast of Northern Ostrobothnia, Finland
Vascular plant and moss species across successional mire basins on the land uplift coast of Northern Ostrobothnia, Finland Open
Succession of mire vegetation was studied in mire basins providing uniform chronosequences on the land uplift coast of the Bothnian Bay. The research was performed from transects crossing mire basins with similar hydrology in order to high…