Explanipedia

Myocardial sympathetic distal axon loss in subjects with Lewy pathology in three autopsy cohorts Open

Ville Kivistö, Benjamin Englert, Jarno Tuimala, Eloise Kok, Henri Puttonen , et al. · 2025

Cardiac manifestations are associated with Lewy body disease, but studies addressing the underlying histopathological mechanisms at the myocardial level are sparse. Here, we generated an artificial intelligence-based algorithm to quantify …

Hippocampal tau distribution in primary age‐related tauopathy: The Vantaa 85+ Study Open

Sara Savola, Jarno Tuimala, Ville Kivistö, Mia Kero, Anna Raunio , et al. · 2025

INTRODUCTION In contrast to Alzheimer's disease (AD), in which initial neurofibrillary tangles (NFT) are mainly limited to the (trans)entorhinal region (EC) and CA1/prosubiculum, primary age‐related tauopathy (PART) has been suggested to e…

LATE‐NC IN THE VERY ELDERLY– THE POPULATION‐BASED VANTAA 85+ ‐STUD Open

Elizaveta Mikhailenko, Kia Colangelo, Jarno Tuimala, Mia Kero, Sara Savola , et al. · 2024

Background Population‐based cohort studies play a crucial role in unraveling the underlying causes of dementia among older individuals. While previous research has indicated an increase in limbic‐predominant age‐related TDP‐43 encephalopat…

Limbic-predominant age-related TDP-43 encephalopathy in the oldest old: a population-based study Open

Elizaveta Mikhailenko, Kia Colangelo, Jarno Tuimala, Mia Kero, Sara Savola , et al. · 2024

Population-based cohort studies are essential for understanding the pathological basis of dementia in older populations. Previous studies have shown that limbic-predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-NC)…

Distribution of Lewy-related pathology in the brain, spinal cord, and periphery: the population-based Vantaa 85 + study Open

Anna Raunio, Ville Kivistö, Mia Kero, Jarno Tuimala, Sara Savola , et al. · 2022

Evolving evidence has supported the existence of two anatomically distinct Lewy-related pathology (LRP) types. Investigation of spinal cord and peripheral LRP can elucidate mechanisms of Lewy body disorders and origins of synuclein accumul…

Glutamine synthetase in human carotid plaque macrophages associates with features of plaque vulnerability: An immunohistological study Open

Pia Sorto, Mikko I. Mäyränpää, Jani Saksi, Krista Nuotio, Petra Ijäs , et al. · 2022

Our results link connect macrophage GLUL expression with carotid plaque features characterizing plaque vulnerability.

Enhancing the adoption of digital public services: Evidence from a large-scale field experiment Open

Ari Hyytinen, Jarno Tuimala, Markus Hammar · 2022

Governments increasingly digitalize the provision of their public services, but these efforts fail to generate expected social benefits if the services remain underutilized. We use a large-scale field experiment to provide causal evidence …

Primary age‐related tauopathy in a Finnish population‐based study of the oldest old (Vantaa 85+) Open

Sara Savola, Karri Kaivola, Anna Raunio, Mia Kero, Mira Mäkelä , et al. · 2021

Aims Few studies have investigated primary age‐related tauopathy (PART) in a population‐based setting. Here, we assessed its prevalence, genetic background, comorbidities and features of cognitive decline in an unselected elderly populatio…

APOE ε4 associates with increased risk of severe COVID-19, cerebral microhaemorrhages and post-COVID mental fatigue: a Finnish biobank, autopsy and clinical study Open

Samu Kurki, Jonas Kantonen, Karri Kaivola, Laura Hokkanen, Mikko I. Mäyränpää , et al. · 2021

Phytoplankton Morpho-Functional Trait Variability along Coastal Environmental Gradients Open

Sirpa Lehtinen, Sanna Suikkanen, Heidi Hällfors, Jarno Tuimala, Harri Kuosa · 2021

We utilized the trait-based approach in a novel way to examine how specific phytoplankton traits are related to physical features connected to global change, water quality features connected to catchment change, and nutrient availability c…

Alpha-synuclein pathology of olfactory bulbs/peduncles in the Vantaa85+ cohort exhibit two divergent patterns: a population-based study Open

Eloise Kok, Sara Savola, Anna Raunio, Minna Oinas, Jarno Tuimala , et al. · 2021

Erratum to: Optimising sampling frequency for monitoring heterotrophic protists in a marine ecosystem Open

Maiju Lehtiniemi, Elaine S. Fileman, Heidi Hällfors, Harri Kuosa, Sirpa Lehtinen , et al. · 2021

Warfarin Treatment Is Associated to Increased Internal Carotid Artery Calcification Open

Krista Nuotio, Suvi Koskinen, Laura Mäkitie, Jarno Tuimala, Petra Ijäs , et al. · 2021

Background: Long-term treatment with the vitamin K antagonist warfarin is widely used for the prevention of venous thrombosis and thromboembolism. However, vitamin K antagonists may promote arterial calcification, a phenomenon that has bee…

Optimising sampling frequency for monitoring heterotrophic protists in a marine ecosystem Open

Maiju Lehtiniemi, Elaine S. Fileman, Heidi Hällfors, Harri Kuosa, Sirpa Lehtinen , et al. · 2021

Heterotrophic protists are essential components of the marine ecosystem, yet they are often excluded from monitoring programmes. With limited resources, monitoring strategies need to be optimised considering both scientific knowledge and a…

Perioperative changes in hemoglobin levels during major hepatopancreatic surgery in transfused and non-transfused patients Open

Jukka-Pekka Lammi, Matti Eskelinen, Jarno Tuimala, Tuomas Selander, Juha Saarnio , et al. · 2020

Background: Several studies have shown that restrictive transfusion policies are safe. However, in clinical practice, transfusion policies seem to be inappropriate. In order to assist in decision-making concerning red blood cell transfusio…

Lewy-related pathology exhibits two anatomically and genetically distinct progression patterns: a population-based study of Finns aged 85+ Open

Anna Raunio, Karri Kaivola, Jarno Tuimala, Mia Kero, Minna Oinas , et al. · 2019

P1‐423: ALZHEIMER'S DISEASE ASSOCIATED LEWY RELATED PATHOLOGY ARISES FROM AMYGDALA Open

Anna Raunio, Karri Kaivola, Jarno Tuimala, Mia Kero, Minna Oinas , et al. · 2019

Lewy related pathology (LRP) follows hierarchical caudo-rostral progression in dementia with Lewy bodies, according to the Braak hypothesis (Braak & Braak, 1991). LRP is also frequently present in combination with Alzheimer's disease (AD).…

Approach for Supporting Food Web Assessments with Multi-Decadal Phytoplankton Community Analyses—Case Baltic Sea Open

Sirpa Lehtinen, Sanna Suikkanen, Heidi Hällfors, Pirkko Kauppila, Maiju Lehtiniemi , et al. · 2016

Combining the existing knowledge on links between functional characteristics of phytoplankton taxa and food web functioning with the methods from long-term data analysis, we present an approach for using phytoplankton monitoring data to dr…

Maternal <span>HLA</span> genotyping is not useful for predicting severity of fetal and neonatal alloimmune thrombocytopenia Open

Susanna Sainio, Kaija Javela, Jarno Tuimala, Katri Haimila · 2016

Summary Lack of reliable laboratory parameters is the main challenge in the management of fetal and neonatal alloimmune thrombocytopenia ( FNAIT ). Despite the long‐known association between the HLA ‐ DRB 3* 01:01 allele and human platelet…

The Use of Blood Products in Adult Patients with Burns Open

Virve Koljonen, Jarno Tuimala, Caj Haglund, Erkki Tukiainen, Jyrki Vuola , et al. · 2016

Introduction: Burn anemia represents a common complication following a burn injury. Burn anemia etiology carries distinct features occurring at each stage of the post-injury and treatment periods resulting from different causes. We aimed t…

Bleeding complications in cholecystectomy: a register study of over 22 000 cholecystectomies in Finland Open

Satu Suuronen, Antti Kivivuori, Jarno Tuimala, Hannu Paajanen · 2015

Laparoscopic cholecystectomy was associated with lower transfusion rates of blood components compared to open surgery. The severity of bleeding complications may not differ substantially between LC and OC.

Diagnosis and treatment of severe hemolytic disease of the fetus and newborn: a 10‐year nationwide retrospective study Open

Susanna Sainio, Irmeli Nupponen, Malla Kuosmanen, Ansa Aitokallio‐Tallberg, Eeva Ekholm , et al. · 2015

Objective Outcome after intrauterine transfusions due to severe hemolytic disease of the fetus and newborn. Design Nationwide population‐based retrospective cohort study. Setting All women treated with intrauterine transfusions for hemolyt…

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