Jarod A. Zepp
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View article: Stc1-expressing myofibroblasts are a developmentally distinct lineage cleared through intrinsic apoptosis in the neonatal lung
Stc1-expressing myofibroblasts are a developmentally distinct lineage cleared through intrinsic apoptosis in the neonatal lung Open
Lung myofibroblasts are necessary for early postnatal alveolar growth and develop again during pathological fibrosis. Determining the unique contributions of multiple myofibroblast lineages to development and disease is hampered by a lack …
View article: A spatiotemporal cell atlas of cardiopulmonary progenitor cell allocation during development
A spatiotemporal cell atlas of cardiopulmonary progenitor cell allocation during development Open
The heart and lung co-orchestrate their development during organogenesis. The mesoderm surrounding both the developing heart and anterior foregut endoderm provides instructive cues guiding cardiopulmonary development. Additionally, it serv…
View article: Dynamics of primary cilia in endothelial and mesenchymal cells throughout mouse lung development
Dynamics of primary cilia in endothelial and mesenchymal cells throughout mouse lung development Open
Cilia are specialized structures found on a variety of mammalian cells, with variable roles in the transduction of mechanical and biological signals (by primary cilia, PC), as well as in the generation of fluid flow (by motile cilia). Thei…
View article: Emergence of inflammatory fibroblasts with aging in Hermansky-Pudlak syndrome associated pulmonary fibrosis
Emergence of inflammatory fibroblasts with aging in Hermansky-Pudlak syndrome associated pulmonary fibrosis Open
View article: Dysregulated alveolar epithelial cell progenitor function and identity in Hermansky-Pudlak syndrome
Dysregulated alveolar epithelial cell progenitor function and identity in Hermansky-Pudlak syndrome Open
Hermansky-Pudlak syndrome (HPS) is a genetic disorder of endosomal protein trafficking associated with pulmonary fibrosis in specific subtypes, including HPS-1 and HPS-2. Single-mutant HPS1 and HPS2 mice display increased fibrotic sensitiv…
View article: Spatiotemporal dynamics of primary and motile cilia throughout lung development
Spatiotemporal dynamics of primary and motile cilia throughout lung development Open
Cilia are specialized structures found on a variety of mammalian cells, with variable roles in the transduction of mechanical and biological signals (by primary cilia, PC), as well as the generation of fluid flow (by motile cilia). Their c…
View article: Marginated Neutrophils in the Lungs Effectively Compete for Nanoparticles Targeted to the Endothelium, Serving as a Part of the Reticuloendothelial System
Marginated Neutrophils in the Lungs Effectively Compete for Nanoparticles Targeted to the Endothelium, Serving as a Part of the Reticuloendothelial System Open
Nanomedicine has long pursued the goal of targeted delivery to specific organs and cell types but has yet to achieve this goal with the vast majority of targets. One rare example of success in this pursuit has been the 25+ years of studies…
View article: Marginated neutrophils in the lungs effectively compete for nanoparticles targeted to the endothelium, serving as a part of the reticuloendothelial system
Marginated neutrophils in the lungs effectively compete for nanoparticles targeted to the endothelium, serving as a part of the reticuloendothelial system Open
Nanomedicine has long pursued the goal of targeted delivery to specific organs and cell types but has not achieved this goal with the vast majority of targets. One rare example of success in this pursuit has been the 25+ years of studies t…
View article: Dynamic Hippo pathway activity underlies mesenchymal differentiation during lung alveolar morphogenesis
Dynamic Hippo pathway activity underlies mesenchymal differentiation during lung alveolar morphogenesis Open
Alveologenesis, the final stage in lung development, substantially remodels the distal lung, expanding the alveolar surface area for efficient gas exchange. Secondary crest myofibroblasts (SCMF) exist transiently in the neonatal distal lun…
View article: Circadian regulation of lung repair and regeneration
Circadian regulation of lung repair and regeneration Open
View article: A Spatiotemporal Cell Atlas of Cardiopulmonary Progenitor Cell Allocation During Development
A Spatiotemporal Cell Atlas of Cardiopulmonary Progenitor Cell Allocation During Development Open
View article: Dynamic Hippo pathway activity underlies mesenchymal differentiation during lung alveolar morphogenesis
Dynamic Hippo pathway activity underlies mesenchymal differentiation during lung alveolar morphogenesis Open
Alveologenesis, the final stage in lung development, substantially remodels the distal lung, expanding the alveolar surface area for efficient gas exchange. Secondary crest myofibroblasts (SCMF) exist transiently in the neonatal distal lun…
View article: Circadian regulation of lung repair and regeneration
Circadian regulation of lung repair and regeneration Open
Optimal lung repair and regeneration are essential for recovery from viral infections, including influenza A virus (IAV). We have previously demonstrated that acute inflammation and mortality induced by IAV is under circadian control. Howe…
View article: Dysregulated alveolar epithelial cell progenitor function and identity in Hermansky-Pudlak syndrome
Dysregulated alveolar epithelial cell progenitor function and identity in Hermansky-Pudlak syndrome Open
Hermansky-Pudlak syndrome (HPS) is a genetic disorder of endosomal protein trafficking associated with pulmonary fibrosis in specific subtypes, including HPS-1 and HPS-2. Single mutant HPS1 and HPS2 mice display increased fibrotic sensitiv…
View article: CXCL12 defines lung endothelial heterogeneity and promotes distal vascular growth
CXCL12 defines lung endothelial heterogeneity and promotes distal vascular growth Open
There is a growing amount of data uncovering the cellular diversity of the pulmonary circulation and mechanisms governing vascular repair after injury. However, the molecular and cellular mechanisms contributing to the morphogenesis and gr…
View article: A CXCL12 morphogen gradient uncovers lung endothelial heterogeneity and promotes distal vascular growth
A CXCL12 morphogen gradient uncovers lung endothelial heterogeneity and promotes distal vascular growth Open
In adults, there is a growing amount of data uncovering the cellular diversity of the pulmonary circulation and mechanisms governing vascular repair after injury, however, molecular and cellular mechanisms contributing to the morphogenesis…
View article: A census of the lung: CellCards from LungMAP
A census of the lung: CellCards from LungMAP Open
The human lung plays vital roles in respiration, host defense, and basic physiology. Recent technological advancements such as single-cell RNA sequencing and genetic lineage tracing have revealed novel cell types and enriched functional pr…
View article: Genomic, epigenomic, and biophysical cues controlling the emergence of the lung alveolus
Genomic, epigenomic, and biophysical cues controlling the emergence of the lung alveolus Open
Transitioning lung for postnatal life The lung is a complex organ composed of multiple cell types, and its alveolus serves as the functional unit of gas exchange. The alveolar type 1 cell (AT1) serves as an active signaling hub in the deve…
View article: STAT3–BDNF–TrkB signalling promotes alveolar epithelial regeneration after lung injury
STAT3–BDNF–TrkB signalling promotes alveolar epithelial regeneration after lung injury Open
View article: <i>p16</i> <sup><i>INK4a</i></sup> and the Alveolar Niche Take Center Stage in Bronchopulmonary Dysplasia
<i>p16</i> <sup><i>INK4a</i></sup> and the Alveolar Niche Take Center Stage in Bronchopulmonary Dysplasia Open
View article: Nanoparticle Delivery of Angiogenic Gene Therapy. Save the Vessels, Save the Lung!
Nanoparticle Delivery of Angiogenic Gene Therapy. Save the Vessels, Save the Lung! Open
View article: Defining the role of pulmonary endothelial cell heterogeneity in the response to acute lung injury
Defining the role of pulmonary endothelial cell heterogeneity in the response to acute lung injury Open
Pulmonary endothelial cells (ECs) are an essential component of the gas exchange machinery of the lung alveolus. Despite this, the extent and function of lung EC heterogeneity remains incompletely understood. Using single-cell analytics, w…
View article: Author response: Defining the role of pulmonary endothelial cell heterogeneity in the response to acute lung injury
Author response: Defining the role of pulmonary endothelial cell heterogeneity in the response to acute lung injury Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Pulmonary endothelial cells (…
View article: Dnmt1 is required for proximal-distal patterning of the lung endoderm and for restraining alveolar type 2 cell fate
Dnmt1 is required for proximal-distal patterning of the lung endoderm and for restraining alveolar type 2 cell fate Open
View article: Cellular crosstalk in the development and regeneration of the respiratory system
Cellular crosstalk in the development and regeneration of the respiratory system Open
View article: IL-17A Recruits Rab35 to IL-17R to Mediate PKCα-Dependent Stress Fiber Formation and Airway Smooth Muscle Contractility
IL-17A Recruits Rab35 to IL-17R to Mediate PKCα-Dependent Stress Fiber Formation and Airway Smooth Muscle Contractility Open
IL-17A is a critical proinflammatory cytokine for the pathogenesis of asthma including neutrophilic pulmonary inflammation and airway hyperresponsiveness. In this study, by cell type–specific deletion of IL-17R and adaptor Act1, we demonst…
View article: Regeneration of the lung alveolus by an evolutionarily conserved epithelial progenitor
Regeneration of the lung alveolus by an evolutionarily conserved epithelial progenitor Open
View article: IL-17A–Induced PLET1 Expression Contributes to Tissue Repair and Colon Tumorigenesis
IL-17A–Induced PLET1 Expression Contributes to Tissue Repair and Colon Tumorigenesis Open
This study identifies a novel mechanism linking IL-17A with colon tissue repair and tumor development. Abrogation of IL-17A signaling in mice attenuated tissue repair of dextran sulfate sodium (DSS)-induced damage in colon epithelium and m…
View article: Distinct Mesenchymal Lineages and Niches Promote Epithelial Self-Renewal and Myofibrogenesis in the Lung
Distinct Mesenchymal Lineages and Niches Promote Epithelial Self-Renewal and Myofibrogenesis in the Lung Open
View article: Emergence of a Wave of Wnt Signaling that Regulates Lung Alveologenesis by Controlling Epithelial Self-Renewal and Differentiation
Emergence of a Wave of Wnt Signaling that Regulates Lung Alveologenesis by Controlling Epithelial Self-Renewal and Differentiation Open
Alveologenesis is the culmination of lung development and involves the correct temporal and spatial signals to generate the delicate gas exchange interface required for respiration. Using a Wnt-signaling reporter system, we demonstrate the…