Jarrett Smith
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The G3BP stress-granule proteins reinforce the integrated stress response translation programme Open
When mammalian cells are exposed to stress, they co-ordinate the condensation of stress granules (SGs) through the action of proteins G3BP1 and G3BP2 (G3BPs) and, simultaneously, undergo a massive reduction in translation. Although SGs and…
The G3BP stress-granule proteins reinforce the integrated-stress-response translation program Open
When mammalian cells are exposed to stress, they coordinate the condensation of stress granules (SGs) through the action of proteins G3BP1 and G3BP2 (G3BPs) and, simultaneously, undergo a massive reduction in translation. Although SGs and …
Single-molecule dynamics of the P granule scaffold MEG-3 in the<i>Caenorhabditis elegans</i>zygote Open
During the asymmetric division of the Caenorhabditis elegans zygote, germ (P) granules are disassembled in the anterior cytoplasm and stabilized/assembled in the posterior cytoplasm, leading to their inheritance by the germline daughter ce…
Analysis of P granules <i>in vivo</i> and <i>ex vivo</i> Open
Corrected version -This version can be cited . RNA granules are dynamic sub-cellular compartments that lack enveloping membranes. RNA granules have been proposed to form by liquid-liquid phase separation, a thermodynamic process that parti…
Spatial patterning of P granules by RNA-induced phase separation of the intrinsically-disordered protein MEG-3 Open
RNA granules are non-membrane bound cellular compartments that contain RNA and RNA binding proteins. The molecular mechanisms that regulate the spatial distribution of RNA granules in cells are poorly understood. During polarization of the…
Author response: Spatial patterning of P granules by RNA-induced phase separation of the intrinsically-disordered protein MEG-3 Open
Full text Figures and data Side by side Abstract eLife digest Introduction Results Discussion Materials and methods References Decision letter Author response Article and author information Metrics Abstract RNA granules are non-membrane bo…
Spatial patterning of P granules by RNA-induced phase separation of the intrinsically-disordered protein MEG-3 Open
RNA granules are non-membrane bound cellular compartments that contain RNA and RNA binding proteins. The molecular mechanisms that regulate the spatial distribution of RNA granules in cells are poorly understood. During polarization of the…