Jarrod W. Barnes
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View article: Wound repair and immune function in the Pseudomonas infected CF lung: before and after highly effective modulator therapy
Wound repair and immune function in the Pseudomonas infected CF lung: before and after highly effective modulator therapy Open
The leading cause of death for people with cystic fibrosis (pwCF) continues to be due to respiratory-related illnesses. Both wound repair and immune cell responses are dysregulated in the CF airways, creating a cycle of unresolved injury a…
View article: Simple and accessible methods for quantifying isolated mucins for further evaluation
Simple and accessible methods for quantifying isolated mucins for further evaluation Open
View article: Simple and Accessible Methods for Quantifying Isolated Mucins for Further Evaluation
Simple and Accessible Methods for Quantifying Isolated Mucins for Further Evaluation Open
View article: From Liver Insights to Lung Innovations: FGF21 and Idiopathic Pulmonary Fibrosis
From Liver Insights to Lung Innovations: FGF21 and Idiopathic Pulmonary Fibrosis Open
View article: Highly Effective Modulator Therapy: Implications for the Microbial Landscape in Cystic Fibrosis
Highly Effective Modulator Therapy: Implications for the Microbial Landscape in Cystic Fibrosis Open
Cystic fibrosis (CF) is an autosomal recessive multisystem disorder caused by mutations in the cystic fibrosis conductance regulator (CFTR) anion channel. In the lungs specifically, CFTR mutations lead to changes in mucus viscosity and def…
View article: Reduced sialylation of airway mucin impairs mucus transport by altering the biophysical properties of mucin
Reduced sialylation of airway mucin impairs mucus transport by altering the biophysical properties of mucin Open
Mucus stasis is a pathologic hallmark of muco-obstructive diseases, including cystic fibrosis (CF). Mucins, the principal component of mucus, are extensively modified with hydroxyl (O)-linked glycans, which are largely terminated by sialic…
View article: FGF receptors mediate cellular senescence in the cystic fibrosis airway epithelium
FGF receptors mediate cellular senescence in the cystic fibrosis airway epithelium Open
The number of adults living with cystic fibrosis (CF) has already increased significantly because of drastic improvements in life expectancy attributable to advances in treatment, including the development of highly effective modulator the…
View article: Reduced Sialylation of Airway Mucin Impairs Mucus Transport by Altering the Biophysical Properties of Mucin
Reduced Sialylation of Airway Mucin Impairs Mucus Transport by Altering the Biophysical Properties of Mucin Open
View article: O-GlcNAc transferase regulates collagen deposition and fibrosis resolution in idiopathic pulmonary fibrosis
O-GlcNAc transferase regulates collagen deposition and fibrosis resolution in idiopathic pulmonary fibrosis Open
Background Idiopathic pulmonary fibrosis (IPF) is a chronic pulmonary disease that is characterized by an excessive accumulation of extracellular matrix (ECM) proteins (e.g. collagens) in the parenchyma, which ultimately leads to respirato…
View article: 407 The OGT/O-GlcNAc Axis Regulates Fibrosis Resolution in Idiopathic Pulmonary Fibrosis
407 The OGT/O-GlcNAc Axis Regulates Fibrosis Resolution in Idiopathic Pulmonary Fibrosis Open
OBJECTIVES/GOALS: Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease characterized by dysregulated collagen accumulation in the lung parenchyma. Our goal is to investigate the role of O-linked N-Acetylglucosamine (O-GlcNAc) tran…
View article: O‐GlcNAc regulates anti‐fibrotic genes in lung fibroblasts through EZH2
O‐GlcNAc regulates anti‐fibrotic genes in lung fibroblasts through EZH2 Open
Epigenetic modifications are involved in fibrotic diseases, such as idiopathic pulmonary fibrosis (IPF), and contribute to the silencing of anti‐fibrotic genes. H3K27me3, a key repressive histone mark, is catalysed by the methyltransferase…
View article: An ex vivo rat trachea model reveals abnormal airway physiology and a gland secretion defect in cystic fibrosis
An ex vivo rat trachea model reveals abnormal airway physiology and a gland secretion defect in cystic fibrosis Open
Cystic fibrosis (CF) is a genetic disease hallmarked by aberrant ion transport that results in delayed mucus clearance, chronic infection, and progressive lung function decline. Several animal models have been developed to study the airway…
View article: Sustained Increases in Cardiomyocyte Protein <i>O</i> ‐Linked β‐N‐Acetylglucosamine Levels Lead to Cardiac Hypertrophy and Reduced Mitochondrial Function Without Systolic Contractile Impairment
Sustained Increases in Cardiomyocyte Protein <i>O</i> ‐Linked β‐N‐Acetylglucosamine Levels Lead to Cardiac Hypertrophy and Reduced Mitochondrial Function Without Systolic Contractile Impairment Open
Background Lifestyle and metabolic diseases influence the severity and pathogenesis of cardiovascular disease through numerous mechanisms, including regulation via posttranslational modifications. A specific posttranslational modification,…
View article: Fibroblast Growth Factor 23 Signaling Does Not Increase Inflammation from Pseudomonas aeruginosa Infection in the Cystic Fibrosis Bronchial Epithelium
Fibroblast Growth Factor 23 Signaling Does Not Increase Inflammation from Pseudomonas aeruginosa Infection in the Cystic Fibrosis Bronchial Epithelium Open
Background and Objectives: Chronic inflammation due to Pseudomonas aeruginosa (PA) infection in people with cystic fibrosis (CF) remains a concerning issue in the wake of modulator therapy initiation. Given the perpetuating cycle of coloni…
View article: A novel in vitro model to study prolonged Pseudomonas aeruginosa infection in the cystic fibrosis bronchial epithelium
A novel in vitro model to study prolonged Pseudomonas aeruginosa infection in the cystic fibrosis bronchial epithelium Open
Pseudomonas aeruginosa (PA) is known to chronically infect airways of people with cystic fibrosis (CF) by early adulthood. PA infections can lead to increased airway inflammation and lung tissue damage, ultimately contributing to decreased…
View article: Fibroblast Growth Factor Signaling in Development and Disease
Fibroblast Growth Factor Signaling in Development and Disease Open
Fibroblast growth factors (FGFs) and their cognate receptors (FGFRs) are important biological molecules with a wide array of pleiotropic functions [...]
View article: Phosphate induces inflammation and exacerbates injury from cigarette smoke in the bronchial epithelium
Phosphate induces inflammation and exacerbates injury from cigarette smoke in the bronchial epithelium Open
View article: Targeting the pentraxin 3/CD44 axis: A potential treatment for pulmonary fibrosis
Targeting the pentraxin 3/CD44 axis: A potential treatment for pulmonary fibrosis Open
Pulmonary fibrosis is characterized by progressive scarring of the lung parenchyma surrounding the alveoli that leads to respiratory failure and ultimately death. The idiopathic form of pulmonary fibrosis (or IPF), while rare in incidence,…
View article: 429 Elevated Phosphate Levels Induce Lung Inflammation and Exacerbate Pulmonary Fibrosis
429 Elevated Phosphate Levels Induce Lung Inflammation and Exacerbate Pulmonary Fibrosis Open
OBJECTIVES/GOALS: Using a cell culture model, we will determine the effects of phosphate on primary lung cell cultures and use our results to delineate a pathway through which these changes are carried out. Using animal models, we will det…
View article: The Glycobiology of Pulmonary Arterial Hypertension
The Glycobiology of Pulmonary Arterial Hypertension Open
Pulmonary arterial hypertension (PAH) is a progressive pulmonary vascular disease of complex etiology. Cases of PAH that do not receive therapy after diagnosis have a low survival rate. Multiple reports have shown that idiopathic PAH, or I…
View article: Modulation of H4K16Ac levels reduces pro-fibrotic gene expression and mitigates lung fibrosis in aged mice
Modulation of H4K16Ac levels reduces pro-fibrotic gene expression and mitigates lung fibrosis in aged mice Open
Histone H4 lysine16 acetylation (H4K16Ac) modulates chromatin structure by serving as a switch from a repressive to a transcriptionally active state. This euchromatin mark is associated with active transcription. In this study, we investig…
View article: 352: Altered mucin sialylation results in delayed mucociliary transport in CF
352: Altered mucin sialylation results in delayed mucociliary transport in CF Open
View article: ST6GAL1 and α2-6 Sialylation Regulates IL-6 Expression and Secretion in Chronic Obstructive Pulmonary Disease
ST6GAL1 and α2-6 Sialylation Regulates IL-6 Expression and Secretion in Chronic Obstructive Pulmonary Disease Open
Chronic obstructive pulmonary disease (COPD) is a systemic disease strongly associated with cigarette smoking, airway inflammation, and acute disease exacerbations. Changes in terminal sialylation and fucosylation of asparagine (N)-linked …
View article: Targeting Aging Pathways in Chronic Obstructive Pulmonary Disease
Targeting Aging Pathways in Chronic Obstructive Pulmonary Disease Open
Chronic obstructive pulmonary disease (COPD) has become a global epidemic and is the third leading cause of death worldwide. COPD is characterized by chronic airway inflammation, loss of alveolar-capillary units, and progressive decline in…
View article: Fibroblast Growth Factor Receptor 4 Deficiency Mediates Airway Inflammation in the Adult Healthy Lung?
Fibroblast Growth Factor Receptor 4 Deficiency Mediates Airway Inflammation in the Adult Healthy Lung? Open
Fibroblast growth factor receptor (FGFR) 4 has been shown to mediate pro-inflammatory signaling in the liver and airway epithelium in chronic obstructive pulmonary disease. In past reports, FGFR4 knockout (Fgfr4 -/- )<…
View article: Specific O-GlcNAc modification at Ser-615 modulates eNOS function
Specific O-GlcNAc modification at Ser-615 modulates eNOS function Open
View article: O-GlcNAc Transferase Regulates TGFb1 Signaling in Idiopathic Pulmonary Fibrosis
O-GlcNAc Transferase Regulates TGFb1 Signaling in Idiopathic Pulmonary Fibrosis Open
View article: Transcriptome Analysis of Muscularized Vessels in Pulmonary Hypertension
Transcriptome Analysis of Muscularized Vessels in Pulmonary Hypertension Open
View article: Fibroblast Growth Factor Signaling as a Mediator of Inflammation and Vascular Remodeling in Pulmonary Diseases
Fibroblast Growth Factor Signaling as a Mediator of Inflammation and Vascular Remodeling in Pulmonary Diseases Open
View article: O-GlcNac Transferase Controls Vascularization in Pulmonary Arterial Hypertension
O-GlcNac Transferase Controls Vascularization in Pulmonary Arterial Hypertension Open