Jasmin Imran Alsous
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View article: The physical consequences of sperm gigantism
The physical consequences of sperm gigantism Open
The male fruit fly produces ∼ 1.8 mm long sperm, thousands of which can be stored until mating in a ∼ 200 µ m sac, the seminal vesicle [1, 2]. While the evolutionary pressures driving such extreme sperm (flagellar) lengths have long been i…
View article: The physical consequences of sperm gigantism
The physical consequences of sperm gigantism Open
The male fruit fly produces ~1.8 mm long sperm, thousands of which can be stored until mating in a ~200 micron sac, the seminal vesicle. While the evolutionary pressures driving such extreme sperm (flagellar) lengths have long been investi…
View article: To be or not to be: <i>orb</i>, the fusome and oocyte specification in <i>Drosophila</i>
To be or not to be: <i>orb</i>, the fusome and oocyte specification in <i>Drosophila</i> Open
In the fruit fly Drosophila melanogaster, two cells in a cyst of 16 interconnected cells have the potential to become the oocyte, but only one of these will assume an oocyte fate as the cysts transition through regions 2a and 2b of the ger…
View article: Fusome topology and inheritance during insect gametogenesis
Fusome topology and inheritance during insect gametogenesis Open
From insects to mammals, oocytes and sperm develop within germline cysts comprising cells connected by intercellular bridges (ICBs). In numerous insects, formation of the cyst is accompanied by growth of the fusome—a membranous organelle t…
View article: Scaling behaviour and control of nuclear wrinkles
Scaling behaviour and control of nuclear wrinkles Open
This repository contains some of the data presented in the article 'Scaling behaviour and control of nuclear wrinkles' by the same authors in Nature Physics (2023). For more details on the methods, see the accompanying manuscript.plotData_…
View article: Dynamics, scaling behavior, and control of nuclear wrinkling
Dynamics, scaling behavior, and control of nuclear wrinkling Open
The cell nucleus is enveloped by a complex membrane, whose wrinkling has been implicated in disease and cellular aging. The biophysical dynamics and spectral evolution of nuclear wrinkling during multicellular development remain poorly und…
View article: Quantitative models for building and growing fated small cell networks
Quantitative models for building and growing fated small cell networks Open
Small cell clusters exhibit numerous phenomena typically associated with complex systems, such as division of labour and programmed cell death. A conserved class of such clusters occurs during oogenesis in the form of germline cysts that g…
View article: Fusome topology and inheritance during insect gametogenesis
Fusome topology and inheritance during insect gametogenesis Open
From insects to mammals, oocytes ad sperm develop within germline cysts comprising cells connected by intercellular bridges (ICBs). In numerous insects, formation of the cyst is accompanied by growth of the fusome – a membranous that perme…
View article: Size scaling in collective cell growth
Size scaling in collective cell growth Open
Size is a fundamental feature of living entities and is intimately tied to their function. Scaling laws, which can be traced to D'Arcy Thompson and Julian Huxley, have emerged as a powerful tool for studying regulation of the growth dynami…
View article: Dynamics of hydraulic and contractile wave-mediated fluid transport during<i>Drosophila</i>oogenesis
Dynamics of hydraulic and contractile wave-mediated fluid transport during<i>Drosophila</i>oogenesis Open
Significance Fluid flow plays an important role during oogenesis. From insects to mice, oocytes mature by acquiring cytoplasm from sister germ cells, yet the biological and physical mechanisms underlying this transport process remain poorl…
View article: Mapping parameter spaces of biological switches
Mapping parameter spaces of biological switches Open
Since the seminal 1961 paper of Monod and Jacob, mathematical models of biomolecular circuits have guided our understanding of cell regulation. Model-based exploration of the functional capabilities of any given circuit requires systematic…
View article: Dynamics of hydraulic and contractile wave-mediated fluid transport during<i>Drosophila</i>oogenesis
Dynamics of hydraulic and contractile wave-mediated fluid transport during<i>Drosophila</i>oogenesis Open
From insects to mice, oocytes develop within cysts alongside nurse-like sister germ cells. Prior to fertilization, the nurse cells’ cytoplasmic contents are transported into the oocyte, which grows as its sister cells regress and die. Alth…
View article: A process engineering approach to increase organoid yield
A process engineering approach to increase organoid yield Open
Temporal manipulation of the in vitro environment and growth factors can direct differentiation of human pluripotent stem cells into organoids, aggregates with multiple tissue-specific cell types and three-dimensional structure mimicking n…