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6-Chloro-3-[4-(hexyloxy)phenyl]-[1,2,4]triazolo[4,3-<i>b</i>]pyridazine Open
Molecules of the title compound, C 17 H 19 ClN 4 O, are essentially planar, the dihedral angles between the planes of the tetraazaindene ring system and the benzene ring and between the benzene ring and the hexyloxy chain being 1.56 (10)° …
View article: CCT196969 effectively inhibits growth and survival of melanoma brain metastasis cells
CCT196969 effectively inhibits growth and survival of melanoma brain metastasis cells Open
Melanomas frequently metastasize to the brain. Despite recent progress in the treatment of melanoma brain metastasis, therapy resistance and relapse of disease remain unsolved challenges. CCT196969 is a SRC family kinase (SFK) and Raf prot…