Explanipedia

Pediatric Case Report and Overview of Autochthonous Tick-Borne Encephalitis, Belgium Open

Justine De Langhe, Jo Sourbron, Robbe Van Herreweghe, Marjan Van Esbroeck, Koen Vercauteren , et al. · 2025

Prevalence of tick-borne encephalitis (TBE) is increasing in much of Europe. In May 2024, an autochthonous pediatric case of TBE was diagnosed in a 6-year-old girl in Belgium. Clinicians should recognize the symptoms and signs of TBE infec…

Outbreak of cutaneous leishmaniasis amongst militia members in a non-endemic district under conflict in the lowlands of Somali Region caused by Leishmania tropica, Eastern Ethiopia Open

Adugna Abera, Henok Tadesse, Dereje Beyene, Desalegn Geleta, Mahlet Belachew , et al. · 2025

Background Cutaneous leishmaniasis (CL) in Ethiopia has typically been linked to high-altitude regions but has recently emerged at an unusually low altitude of 500 meters in the Somali Region, raising public health concerns. Cutaneous leis…

Protracted Katayama syndrome in an immunocompromised traveller: the challenge of assessing cure Open

Steven Van Den Broucke, Rik Schrijvers, Marjan Van Esbroeck, Jasmine Coppens, Emmanuel Bottieau , et al. · 2024

We describe a case of prolonged Katayama syndrome in an immunocompromised traveller. We highlight the difficulty of evaluating a cure due to persistent polymerase chain reaction (PCR) positivity and fluctuating markers. We discuss limitati…

Outbreak ofLeishmania tropicaamongst militia members in a non-endemic district under conflict in the lowlands of Somali Region in Ethiopia Open

Adugna Abera, Henok Tadesse, Dereje Beyene, Desalegn Geleta, Ebise Abose , et al. · 2024

Following the emergence of a conflict, an outbreak of cutaneous leishmaniasis (CL) occurred in a non- endemic lowland area in the Somali Region in Ethiopia, raising public health concerns. All 1050 patients were militia members, immunologi…

Evaluation of the Allplex GI Parasite and Helminth PCR Assay in a Belgian Travel Clinic Open

Jasmine Coppens, Charlotte Drieghe, Idzi Potters, Jean-Marc Schwob, Marjan Van Esbroeck · 2024

Recently a number of broad-range stool parasite PCR assays have been developed. However, there is ongoing disagreement regarding their diagnostic performance, as various studies have produced contradictory results. In this study, we compar…

Nationwide quality assurance of high-throughput diagnostic molecular testing during the SARS-CoV-2 pandemic: role of the Belgian National Reference Centre Open

Reile Janssen, Lize Cuypers, Lies Laenen, Els Keyaerts, Kurt Beuselinck , et al. · 2024

Failure of artemether-lumefantrine therapy in travellers returning to Belgium with Plasmodium falciparum malaria: an observational case series with genomic analysis Open

Jan Pierreux, Emmanuel Bottieau, Éric Florence, Ula Maniewski, Anne Bruggemans , et al. · 2023

Background Failure of artemisinin-based combination therapy is increasingly reported in patients with Plasmodium falciparum malaria in sub-Saharan Africa. We aimed to describe the clinical and genomic characteristics of recent cases of P. …

Correction: Plasma protein biomarkers reflective of the host response in patients developing Intensive Care Unit-acquired pneumonia Open

Tjitske S. R. van Engelen, Tom D. Y. Reijnders, Fleur P. Paling, Marc J. M. Bonten, Leen Timbermont , et al. · 2023

No Varicella Zoster Virus Infection among Mpox Cases in Antwerp, Belgium Open

Jasmine Coppens, Laurens Liesenborghs, Koen Vercauteren, Marjan Van Esbroeck, Christophe Van Dijck · 2023

Several studies in tropical settings have reported that ∼20% of patients infected with Monkeypox virus (MPXV) also tested polymerase chain reaction (PCR) positive for Varicella zoster virus (VZV). Researchers have hypothesized that VZV inf…

Detection of mpox virus in ambient air in a sexual health clinic Open

Joren Raymenants, Liesbeth Van Gestel, Jasmine Coppens, Tessa de Block, Eugene Bangwen , et al. · 2023

Plasma protein biomarkers reflective of the host response in patients developing Intensive Care Unit-acquired pneumonia Open

Tjitske S. R. van Engelen, Tom D. Y. Reijnders, Fleur P. Paling, Marc J. M. Bonten, Leen Timbermont , et al. · 2023

Immunovirological and environmental screening reveals actionable risk factors for fatal COVID-19 during post-vaccination nursing home outbreaks Open

Lize Cuypers, Els Keyaerts, Samuel L. Hong, Sarah Gorissen, Soraya Maria Menezes , et al. · 2023

Presymptomatic viral shedding in high‐risk mpox contacts: A prospective cohort study Open

Isabel Brosius, Christophe Van Dijck, Jasmine Coppens, Leen Vandenhove, Eugene Bangwen , et al. · 2023

The risk of infection after exposure to clade IIb mpox virus (MPXV) is unknown, and potential presymptomatic shedding of MPXV remains to be demonstrated. High‐risk contacts of mpox patients were followed‐up in a prospective longitudinal co…

Characteristics of confirmed mpox cases among clinical suspects: A prospective single-centre study in Belgium during the 2022 outbreak Open

Matilde Hens, Isabel Brosius, Nicole Berens‐Riha, Jasmine Coppens, Liesbeth Van Gestel , et al. · 2023

No Evidence for Clade I Monkeypox Virus Circulation, Belgium Open

Laurens Liesenborghs, Jasmine Coppens, Christophe Van Dijck, Isabel Brosius, Irith De Baetselier , et al. · 2023

Alternative sampling specimens for the molecular detection of mpox (formerly monkeypox) virus Open

Jasmine Coppens, Fien Vanroye, Isabel Brosius, Laurens Liesenborghs, Saskia van Henten , et al. · 2022

Mpox screening in high-risk populations finds no asymptomatic cases Open

Christophe Van Dijck, Irith De Baetselier, Chris Kenyon, Laurens Liesenborghs, Koen Vercauteren , et al. · 2022

In their Correspondence, Abdullah Reda and colleagues emphasised the importance of undiagnosed mpox (formally known as monkeypox) cases and called for surveillance with rapid diagnostic or home-based tests.1 We agree that the threshold for…

Pre- and asymptomatic viral shedding in high-risk contacts of monkeypox cases: a prospective cohort study Open

Isabel Brosius, Christophe Van Dijck, Jasmine Coppens, Leen Vandenhove, Eugene Bangwen , et al. · 2022

A bstract Epidemiological data suggest that clade IIb monkeypox virus (MPXV) is readily transmitted during sexual contact, even before symptom onset. However, presymptomatic shedding of MPXV remains to be demonstrated. Here, we prospective…

Genomic analysis of methicillin-resistant Staphylococcus aureus clonal complex 239 isolated from Danish patients with and without an international travel history Open

Jasmine Coppens, Basil Britto Xavier, Jelle Vlaeminck, Jesper Larsen, Christine Lammens , et al. · 2022

Introduction International travel has been a major determinant for the introduction of pathogens such as methicillin-resistant Staphylococcus aureus (MRSA) into naïve geographic areas. MRSA clonal complex 239 (CC239) is a highly virulent c…

Retrospective detection of asymptomatic monkeypox virus infections among male sexual health clinic attendees in Belgium Open

Irith De Baetselier, Christophe Van Dijck, Chris Kenyon, Jasmine Coppens, Johan Míchiels , et al. · 2022

Asymptomatic monkeypox virus infections among male sexual health clinic attendees in Belgium Open

Irith De Baetselier, Christophe Van Dijck, Chris Kenyon, Jasmine Coppens, Dorien Van den Bossche , et al. · 2022

Background Monkeypox is transmitted by close contact with symptomatic cases, and those infected are assumed to be uniformly symptomatic. Evidence of subclinical monkeypox infection is limited to a few immunological studies which found evid…

Detection of SARS-CoV-2 in young children attending day-care centres in Belgium, May 2020 to February 2022 Open

Liesbet Van Heirstraeten, Esra Ekinci, Mathias Smet, Matilda Berkell, Laura Willen , et al. · 2022

Presence of SARS-CoV-2 was monitored in nasopharyngeal samples from young children aged 6−30 months attending day-care centres (DCCs) in Belgium from May 2020−February 2022. SARS-CoV-2 carriage among DCC children was only detected from Nov…

Asymptomatic Monkeypox Virus Infections Among Male Sexual Health Clinic Attendees in Belgium Open

Irith De Baetselier, Christophe Van Dijck, Chris Kenyon, Jasmine Coppens, Dorien Van den Bossche , et al. · 2022

Monitoring the SARS-CoV-2 pandemic: screening algorithm with single nucleotide polymorphism detection for the rapid identification of established and emerging variants Open

Joachim C. Mertens, Jasmine Coppens, Katherine Loens, Marie Le Mercier, Basil Britto Xavier , et al. · 2021

Novel vancomycin resistance gene cluster in Enterococcus faecium ST1486, Belgium, June 2021 Open

Basil Britto Xavier, Jasmine Coppens, Sien De Koster, Sahaya Glingston Rajakani, Sam Van Goethem , et al. · 2021

We identified a novel van gene cluster in a clinical Enterococcus faecium isolate with vancomycin minimum inhibitory concentration (MIC) of 4 µg/mL. The ligase gene, vanP , was part of a van operon cluster of 4,589 bp on a putative novel i…

Evaluation of GeneXpert PA assay compared to genomic and (semi-)quantitative culture methods for direct detection of Pseudomonas aeruginosa in endotracheal aspirates Open

Thomas van der Schalk, Jasmine Coppens, Leen Timbermont, Agata Turlej-Rogacka, Liesbet Van Heirstraeten , et al. · 2021

Introduction Pseudomonas aeruginosa is a common cause of ventilator-associated pneumonia (VAP). Rapid and accurate detection of lower respiratory tract colonization and/or infection with P. aeruginosa may advise targeted preventive (antibo…

1486. Phylogenetic and alpha toxin variant analyses of Staphylococcus aureus strains isolated from patients during the SAATELLITE study Open

David E. Tabor, Christine Tkaczyk, Andrey Tovchigrechko, Bret R. Sellman, Michael McCarthy , et al. · 2020

Background Suvratoxumab is a human monoclonal antibody that neutralizes S. aureus (SA) alpha toxin (AT). SAATELLITE, a phase 2 study of the safety and efficacy of suvratoxumab for reducing the incidence of SA pneumonia (NCT02296320), was c…

ResFinder 4.0 for predictions of phenotypes from genotypes Open

Valeria Bortolaia, Rolf Sommer Kaas, Étienne Ruppé, Marilyn C. Roberts, Štefan Schwarz , et al. · 2020

Objectives WGS-based antimicrobial susceptibility testing (AST) is as reliable as phenotypic AST for several antimicrobial/bacterial species combinations. However, routine use of WGS-based AST is hindered by the need for bioinformatics ski…

Comparison of commercial realtime reverse transcription PCR assays for the detection of SARS-CoV-2 Open

Zsὁfia Iglὁi, M Leven, Zain Abdel-Karem Abou-Nouar, Babette Weller, Veerle Matheeussen , et al. · 2020

The emergence of a new coronavirus in Wuhan China has triggered a global need for accurate diagnostic assays. Initially, mostly laboratory developed molecular tests were available but shortly thereafter different commercial assays started …

Remarkable Genome Stability among emm1 Group A Streptococcus in Belgium over 19 Years Open

Jasmine Coppens, Basil Britto Xavier, Katherine Loens, Christine Lammens, Margareta Ieven , et al. · 2019

During the last two decades, there has been a public health concern of severe invasive infections caused by Group A Streptococcus (GAS) of the emm1 genotype. This study investigated the dynamics of emm1 GAS during 1994-2013 in Belgium. emm…

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