Jasmine H. Francis
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View article: Blood-Based Cell-Free DNA in Ophthalmic Oncology
Blood-Based Cell-Free DNA in Ophthalmic Oncology Open
cfDNA science bridges the gap between basic research and clinical care. Within the field of ophthalmic oncology, cfDNA may be useful as a diagnostic/prognostic tool, for surveillance of metastatic or minimally residual disease, to identify…
View article: RAF-independent MEK mutations drive refractory histiocytic neoplasms but respond to ERK inhibition
RAF-independent MEK mutations drive refractory histiocytic neoplasms but respond to ERK inhibition Open
Histiocytic neoplasms are clonal disorders of the monocyte/macrophage lineage defined by mutations activating mitogen-activated protein kinase (MAPK) signaling. Recently, the MEK1/2 inhibitor cobimetinib was FDA-approved for patients with …
View article: High-dose topotecan (90 and 180 μG) for recurrent subretinal and vitreous seeding in retinoblastoma
High-dose topotecan (90 and 180 μG) for recurrent subretinal and vitreous seeding in retinoblastoma Open
View article: Proton Therapy for Uveal Melanoma on a Pencil Beam Scanning Gantry
Proton Therapy for Uveal Melanoma on a Pencil Beam Scanning Gantry Open
View article: Intraocular Pressure Changes following Intravitreal Topotecan 90 μg/0.18 cc for the Treatment of Retinoblastoma
Intraocular Pressure Changes following Intravitreal Topotecan 90 μg/0.18 cc for the Treatment of Retinoblastoma Open
Introduction: The aim of this study was to investigate the impact of injecting Topotecan 90 μg/0.18 cc on intraocular pressure (IOP) in children with retinoblastoma. Methods: This was a retrospective study of 78 eye encounters of 37 patien…
View article: Detection and Characterization of <i>RB1</i> Mosaicism in Patients With Retinoblastoma Receiving cfDNA Test
Detection and Characterization of <i>RB1</i> Mosaicism in Patients With Retinoblastoma Receiving cfDNA Test Open
Importance Plasma cell-free DNA (cfDNA) testing is increasingly used for disease diagnosis and monitoring in retinoblastoma, with RB1 allele fraction in cfDNA actively corresponding to disease status and treatment response. However, while …
View article: Gantry-based pencil beam scanning proton therapy for uveal melanoma: IMPT versus proton arc therapy
Gantry-based pencil beam scanning proton therapy for uveal melanoma: IMPT versus proton arc therapy Open
View article: Gantry-based Pencil Beam Scanning (PBS) proton therapy for uveal melanoma: IMPT versus proton arc therapy
Gantry-based Pencil Beam Scanning (PBS) proton therapy for uveal melanoma: IMPT versus proton arc therapy Open
View article: A phase I, first-in-human trial of KO-947, an ERK1/2 inhibitor, in patients with advanced solid tumors
A phase I, first-in-human trial of KO-947, an ERK1/2 inhibitor, in patients with advanced solid tumors Open
View article: Mucocutaneous Adverse Events in Patients With Cancer Treated with the Highly Selective RET Kinase Inhibitor Selpercatinib (LOXO-292)
Mucocutaneous Adverse Events in Patients With Cancer Treated with the Highly Selective RET Kinase Inhibitor Selpercatinib (LOXO-292) Open
View article: Data from A Phase II Study Assessing Long-term Response to Ibrutinib Monotherapy in Recurrent or Refractory CNS Lymphoma
Data from A Phase II Study Assessing Long-term Response to Ibrutinib Monotherapy in Recurrent or Refractory CNS Lymphoma Open
Purpose:Ibrutinib is a first-in-class inhibitor of Bruton tyrosine kinase. We previously reported the safety and short-term antitumor activity of ibrutinib in 20 patients with relapsed or refractory (r/r) primary central nervous system (CN…
View article: Supplementary Data 1 from A Phase II Study Assessing Long-term Response to Ibrutinib Monotherapy in Recurrent or Refractory CNS Lymphoma
Supplementary Data 1 from A Phase II Study Assessing Long-term Response to Ibrutinib Monotherapy in Recurrent or Refractory CNS Lymphoma Open
Additional data
View article: Data from A Phase II Study Assessing Long-term Response to Ibrutinib Monotherapy in Recurrent or Refractory CNS Lymphoma
Data from A Phase II Study Assessing Long-term Response to Ibrutinib Monotherapy in Recurrent or Refractory CNS Lymphoma Open
Purpose:Ibrutinib is a first-in-class inhibitor of Bruton tyrosine kinase. We previously reported the safety and short-term antitumor activity of ibrutinib in 20 patients with relapsed or refractory (r/r) primary central nervous system (CN…
View article: Supplementary Data 1 from A Phase II Study Assessing Long-term Response to Ibrutinib Monotherapy in Recurrent or Refractory CNS Lymphoma
Supplementary Data 1 from A Phase II Study Assessing Long-term Response to Ibrutinib Monotherapy in Recurrent or Refractory CNS Lymphoma Open
Additional data
View article: Histiocytosis of the orbit and its association with <i>KRAS</i> mutations
Histiocytosis of the orbit and its association with <i>KRAS</i> mutations Open
View article: Improved method of dilating pupils for ophthalmic exams under anesthesia (faster and easier)
Improved method of dilating pupils for ophthalmic exams under anesthesia (faster and easier) Open
The use of a combined dilating drop that incorporated Tropicamide 1%, Phenylephrine 2.5%, Proparacaine 0.5% and Ketorolac 0.5% significantly shortened the time for exams under anesthesia for children with retinoblastoma because the pupil r…
View article: Plasma-Derived Cell-Free DNA for the Diagnosis of Ocular-Involving Histiocytosis
Plasma-Derived Cell-Free DNA for the Diagnosis of Ocular-Involving Histiocytosis Open
Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.
View article: Mixed histiocytic neoplasms: A multicentre series revealing diverse somatic mutations and responses to targeted therapy
Mixed histiocytic neoplasms: A multicentre series revealing diverse somatic mutations and responses to targeted therapy Open
Summary Histiocytic neoplasms are diverse clonal haematopoietic disorders, and clinical disease is mediated by tumorous infiltration as well as uncontrolled systemic inflammation. Individual subtypes include Langerhans cell histiocytosis (…
View article: Clearance of plasma cell free DNA in metastatic uveal melanoma with radiographic response to immune checkpoint inhibitors
Clearance of plasma cell free DNA in metastatic uveal melanoma with radiographic response to immune checkpoint inhibitors Open
Clearance of cell free DNA in metastatic uveal melanoma may be associated with radiographic response to immune checkpoint inhibitors.
View article: Circulating Tumor DNA Posttreatment Measurements and Clinical Correlates in Retinoblastoma
Circulating Tumor DNA Posttreatment Measurements and Clinical Correlates in Retinoblastoma Open
Importance Plasma measurements of RB1 circulating tumor DNA (ctDNA) after completion of treatment may be associated with the development of metastases in patients with retinoblastoma. Objective To determine if the absence of previously det…
View article: Non-RB1 germline cancer predisposing variants found in retinoblastoma patients
Non-RB1 germline cancer predisposing variants found in retinoblastoma patients Open
View article: How Much Time Do Focal Treatments for Retinoblastoma Add to Anesthetic Exposure?
How Much Time Do Focal Treatments for Retinoblastoma Add to Anesthetic Exposure? Open
Introduction: Children with retinoblastoma have anesthesia for exams and treatment, but there is little information about how long treatment interventions (laser, cryotherapy, and intravitreal injections) add to routine exams…
View article: MEK Inhibitor-Associated Ocular Hypertension
MEK Inhibitor-Associated Ocular Hypertension Open
Introduction: Mitogen-activated protein kinase kinase (MEK) inhibitors are targeted anticancer agents that are prescribed to treat a broad range of cancers. Despite their strong efficacy profile, MEK inhibitors have been asso…
View article: INNV-42. INTRA-ARTERIAL MELPHALAN FOR HISTIOCYTIC NEOPLASMS INVOLVING NEUROLOGIC, OCULAR, AND HEAD AND NECK STRUCTURES
INNV-42. INTRA-ARTERIAL MELPHALAN FOR HISTIOCYTIC NEOPLASMS INVOLVING NEUROLOGIC, OCULAR, AND HEAD AND NECK STRUCTURES Open
BACKGROUND Histiocytic neoplasms are clonal hematopoietic disorders of myeloid lineage. Involvement of neurologic structures by histiocytic infiltration or disease-associated neurodegeneration (ND) represents a severe disease phenotype ass…
View article: An Evaluation of Urease A Subunit Nanocapsules as a Vaccine in a Mouse Model of Helicobacter pylori Infection
An Evaluation of Urease A Subunit Nanocapsules as a Vaccine in a Mouse Model of Helicobacter pylori Infection Open
Using removable silica templates, protein nanocapsules comprising the A subunit of Helicobacter pylori urease (UreA) were synthesised. The templates were of two sizes, with solid core mesoporous shell (SC/MS) silica templates giving rise t…
View article: Pharmacokinetics of Orbital Topotecan After Ophthalmic Artery Chemosurgery and Intravenous Infusion in the Swine Model
Pharmacokinetics of Orbital Topotecan After Ophthalmic Artery Chemosurgery and Intravenous Infusion in the Swine Model Open
OAC of topotecan resulted in higher orbital exposure than after IV infusion and was a more selective route for local drug delivery. Patients with orbital retinoblastoma may benefit from a multimodal treatment strategy including OAC therapy.
View article: Conjunctival Melanoma and Cell-Free DNA Regression With Ipilimumab/Nivolumab and Stereotactic Radiosurgery
Conjunctival Melanoma and Cell-Free DNA Regression With Ipilimumab/Nivolumab and Stereotactic Radiosurgery Open
A woman in her 50s presented with right upper fornix conjunctival melanocytic mass extending from the bulbar onto the palpebral conjunctiva (Fig. 1), visual acuity 20/25 right eye. Outside incisional biopsy confirmed epithelioid melanoma (…
View article: Outcomes after interruption of targeted therapy in patients with histiocytic neoplasms
Outcomes after interruption of targeted therapy in patients with histiocytic neoplasms Open
Summary Little is known about outcomes following interruption of targeted therapy in adult patients with histiocytic neoplasms. This is an IRB‐approved study of patients with histiocytic neoplasms whose BRAF and MEK inhibitors were interru…
View article: Determinants of overall survival in patients with metastatic uveal melanoma
Determinants of overall survival in patients with metastatic uveal melanoma Open
Background Despite improvements in the treatment of primary uveal melanoma (UM), patients with metastatic disease continue to exhibit poor survival. Methods A retrospective review of metastatic UM patients at Yale (initial cohort) and Memo…
View article: CSF1R inhibition for histiocytic neoplasm with CBL mutations refractory to MEK1/2 inhibition
CSF1R inhibition for histiocytic neoplasm with CBL mutations refractory to MEK1/2 inhibition Open
Histiocytic neoplasms are rare clonal hematopoietic disorders occupying a wide clinical spectrum amongst adults and children.Identification of recurrent somatic mutations in the mitogen activated protein kinase (MAPK) pathway has reframed …