Explanipedia

Total cell N-glycosylation is altered during differentiation of induced pluripotent stem cells to neural stem cells and is disturbed by trisomy 21 Open

Ana Cindrić, Frano Vučković, Aoife Murray, Thomas Klarić, Ivan Alić , et al. · 2024

Down syndrome (DS), a genetic condition caused by trisomy 21 (T21), manifests various neurological symptoms, including intellectual disability, early neurodegeneration, and early-onset dementia. N-glycosylation is a protein modification th…

The importance of <span>IgG</span> glycosylation—What did we learn after analyzing over 100,000 individuals Open

Jasminka Krištić, Gordan Lauc · 2024

Summary All four subclasses of immunoglobulin G (IgG) antibodies have glycan structures attached to the protein part of the IgG molecules. Glycans linked to the Fc portion of IgG are found in all IgG antibodies, while about one‐fifth of Ig…

Glycosylation Research in Bovines-the Significance and Recent Updates Open

Anđelo Beletić, Ivana Duvnjak Orešković, Tea Pribić, Jasminka Krištić, Gordan Lauc · 2024

Glycosylation is an enzymatic process of attaching carbohydrate chains, glycans, to bi-omolecules, thereby influencing their biological features. Understanding the glycosyla-tion patterns and mechanisms in bovines (Bos taurus) has the pote…

Mapping of the gene network that regulates glycan clock of ageing Open

Azra Frkatović-Hodžić, Anika Mijakovac, Karlo Miškec, Arina Nostaeva, Sodbo Sharapov , et al. · 2023

Glycans are an essential structural component of immunoglobulin G (IgG) that modulate its structure and function. However, regulatory mechanisms behind this complex posttranslational modification are not well known. Previous genome-wide as…

Long-Term Culturing of FreeStyle 293-F Cells Affects Immunoglobulin G Glycome Composition Open

Fran Lukšić, Anika Mijakovac, Goran Josipović, Vedrana Vičić Bočkor, Jasminka Krištić , et al. · 2023

Glycosylation of IgG regulates the effector function of this antibody in the immune response. Glycosylated IgG is a potent therapeutic used for both research and clinical purposes. While there is ample research on how different cell cultur…

Dose imbalance of DYRK1A kinase causes systemic progeroid status in Down syndrome by increasing the un-repaired DNA damage and reducing LaminB1 levels Open

Aoife Murray, Gillian Gough, Ana Cindrić, Frano Vučković, David Koschut , et al. · 2023

Main funding came from the "Research Cooperability" Program of the Croatian Science Foundation funded by the European Union from the European Social Fund under the Operational Programme Efficient Human Resources 2014-2020, Project PZS-2019…

Total cell N-glycosylation is altered during neuronal differentiation of iPSC to NSC and is disturbed by trisomy 21 Open

Ana Cindrić, Frano Vučković, Aoife Murray, Thomas Klarić, Ivan Alić , et al. · 2023

Down syndrome (DS) is a genetic condition caused by trisomy 21 (T21) and characterized by a range of neurological symptoms including intellectual disability, early onset of neurodegeneration and dementia, some of which can be attributed to…

Mapping of the gene network that regulates glycan clock of ageing Open

Azra Frkatović-Hodžić, Karlo Miškec, Anika Mijakovac, Arina Nostaeva, Sodbo Sharapov , et al. · 2023

Glycans are an essential structural component of Immunoglobulin G (IgG) that modulate its structure and function. However, regulatory mechanisms behind this complex posttranslational modification are not well known. Previous genome-wide as…

Genome-Wide Methylation Profiling in 229 Patients With Crohn’s Disease Requiring Intestinal Resection: Epigenetic Analysis of the Trial of Prevention of Post-operative Crohn’s Disease (TOPPIC) Open

Nicholas T. Ventham, Nicholas A. Kennedy, Rahul Kalla, Alex Adams, Alexandra Noble , et al. · 2023

We demonstrate differential methylation and differentially variable methylation in patients developing clinical recurrence within 3 years of surgery. Moreover, we report replication of the CD-associated methylome, previously characterized …

A Transient Expression System with Stably Integrated CRISPR-dCas9 Fusions for Regulation of Genes Involved in Immunoglobulin G Glycosylation Open

Anika Mijakovac, Karlo Miškec, Jasminka Krištić, Vedrana Vičić Bočkor, Vanja Tadić , et al. · 2022

Alternative glycosylation of immunoglobulin G (IgG) is functionally important in multiple human physiological and pathological states. Our understanding of molecular mechanisms that regulate IgG glycosylation is vague because of the comple…

Accelerated biological aging in people with Down syndrome with full and segmental trisomy 21 begins in childhood as revealed by immunoglobulin G glycosylation Open

Ana Cindrić, Frano Vučković, David Koschut, Vincenzo Borelli, Julija Jurić , et al. · 2021

Cells from people with Down syndrome (DS) show faster accumulation of DNA damage and epigenetic aging marks. Causative mechanisms remain un-proven and hypotheses range from amplified chromosomal instability to actions of several supernumer…

Targeting B cells in the pre-phase of systemic autoimmunity globally interferes with autoimmune pathology Open

Anja Werner, Simon T. Schafer, Olga O. Zaytseva, Heike Albert, Anja Lux , et al. · 2021

Effects of Estradiol on Immunoglobulin G Glycosylation: Mapping of the Downstream Signaling Mechanism Open

Anika Mijakovac, Julija Jurić, Wendy M. Kohrt, Jasminka Krištić, Domagoj Kifer , et al. · 2021

Glycans attached to immunoglobulin G (IgG) directly affect this antibody effector functions and regulate inflammation at several levels. The composition of IgG glycome changes significantly with age. In women, the most notable change coinc…

Replication of 15 loci involved in human plasma protein N-glycosylation in 4802 samples from four cohorts Open

Sodbo Sharapov, Alexandra S. Shadrina, Yakov A. Tsepilov, Elizaveta E. Elgaeva, Evgeny Tiys , et al. · 2020

Human protein glycosylation is a complex process, and its in vivo regulation is poorly understood. Changes in glycosylation patterns are associated with many human diseases and conditions. Understanding the biological determinants of prote…

Genetic Variants of the MGAT5 Gene Are Functionally Implicated in the Modulation of T Cells Glycosylation and Plasma IgG Glycome Composition in Ulcerative Colitis Open

Márcia S. Pereira, Cecília Durães, Telmo Catarino, José Luís Costa, Isabelle Cleynen , et al. · 2020

OBJECTIVES: The impact of genetic variants (single nucleotide polymorphisms [SNPs]) in the clinical heterogeneity of ulcerative colitis (UC) remains unclear. We showed that patients with UC exhibit a deficiency in MGAT5 glycogene transcrip…

Fc-Linked IgG N-Glycosylation in FcγR Knock-Out Mice Open

Olga O. Zaytseva, Michaela Seeling, Jasminka Krištić, Gordan Lauc, Marija Pezer , et al. · 2020

Immunoglobulin G (IgG) is the most abundant immunoglobulin isotype in the blood and is involved in the pathogenesis and progression of various diseases. Glycosylation of the IgG fragment crystallizable (Fc) region is shown to vary in diffe…

Glycosylation of immunoglobulin G is regulated by a large network of genes pleiotropic with inflammatory diseases Open

Lucija Klarić, Yakov A. Tsepilov, Chloë M. Stanton, Massimo Mangino, Timo Tõnis Sikka , et al. · 2020

Variation in key transcription factors and glycogenes modifies IgG glycosylation and has an influence on inflammatory diseases.

Minimal B Cell Extrinsic IgG Glycan Modifications of Pro- and Anti-Inflammatory IgG Preparations in vivo Open

Anja Werner, Maja Hanić, Mislav Novokmet, Olga O. Zaytseva, Jasminka Krištić , et al. · 2020

Select residues in the biantennary sugar moiety attached to the fragment crystallizable of immunoglobulin G (IgG) antibodies can modulate IgG effector functions. Thus, afucosylated IgG glycovariants have enhanced cytotoxic activity, wherea…

Glycosylation of immunoglobulin G is regulated by a large network of genes pleiotropic with inflammatory diseases Open

Lucija Klarić, Yakov A. Tsepilov, Chloë M. Stanton, Massimo Mangino, Timo Tõnis Sikka , et al. · 2020

Effector functions of immunoglobulin G (IgG) are regulated by the composition of a glycan moiety, thus affecting activity of the immune system. Aberrant glycosylation of IgG has been observed in many diseases, but little is understood abou…

Fc-linked N-glycosylation of murine IgG1 variants Open

Olga Zaitseva, Jasminka Krištić, Marija Pezer, Grant Morahan, Gordan Lauc · 2019

Defining the genetic control of human blood plasma N-glycome using genome-wide association study Open

Sodbo Sharapov, Yakov A. Tsepilov, Lucija Klarić, Massimo Mangino, Gaurav Thareja , et al. · 2019

Glycosylation is a common post-translational modification of proteins. Glycosylation is associated with a number of human diseases. Defining genetic factors altering glycosylation may provide a basis for novel approaches to diagnostic and …

Defining the genetic control of human blood plasma N-glycome using genome-wide association study Open

Sodbo Sharapov, Yakov A. Tsepilov, Lucija Klarić, Massimo Mangino, Gaurav Thareja , et al. · 2018

Glycosylation is a common post-translational modification of proteins. It is known, that glycans are directly involved in the pathophysiology of every major disease. Defining genetic factors altering glycosylation may provide a basis for n…

Plasma N-glycome composition associates with chronic low back pain Open

Irena Trbojević‐Akmačić, Frano Vučković, Marija Vilaj, Andrea Skelin, Lennart C. Karssen , et al. · 2018

To our knowledge, this is a first large clinical study on CLBP patients and plasma N-glycome providing a new glycomics perspective on potential disease pathology.

Genome-wide association summary statistics for human blood plasma glycome Open

Sodbo Sharapov, Yakov A. Tsepilov, Lucija Klarić, Massimo Mangino, Gaurav Thareja , et al. · 2018

The dataset contains results of genome-wide association study of human blood plasma glycome. The 113 files contain association summary statistics for 113 glycome traits, of which 36 were directly measured by UPLC technology and 77 were der…

Genome-wide association summary statistics for human blood plasma glycome Open

Sodbo Sharapov, Yakov A. Tsepilov, Lucija Klarić, Massimo Mangino, Gaurav Thareja , et al. · 2018

The dataset contains results of genome-wide association study of human blood plasma glycome. The 113 files contain association summary statistics for 113 glycome traits, of which 36 were directly measured by UPLC technology and 77 were der…

Plasma N-Glycan Signatures Are Associated With Features of Inflammatory Bowel Diseases Open

Florent Clerc, Mislav Novokmet, Viktoria Dotz, Karli R. Reiding, Noortje de Haan , et al. · 2018

Glycosylation of Immunoglobulin G Associates With Clinical Features of Inflammatory Bowel Diseases Open

Mirna Šimurina, Noortje de Haan, Frano Vučković, Nicholas A. Kennedy, Jerko Štambuk , et al. · 2018

IgG glycosylation and DNA methylation are interconnected with smoking Open

Annika Wahl, Silva Kasela, Elena Carnero‐Montoro, Maarten van Iterson, Jerko Štambuk , et al. · 2017

An epigenome-wide analysis conducted in four population-based cohorts revealed an association between DNA methylation and IgG glycosylation patterns. Presumably, DNA methylation mediates the effect of smoking on IgG glycosylation.

The N-Glycosylation of Mouse Immunoglobulin G (IgG)-Fragment Crystallizable Differs Between IgG Subclasses and Strains Open

Noortje de Haan, Karli R. Reiding, Jasminka Krištić, Agnes L. Hipgrave Ederveen, Gordan Lauc , et al. · 2017

N-linked glycosylation of the fragment crystallizable (Fc)-region of immunoglobulin G (IgG) is known to have a large influence on the activity of the antibody, an effect reported to be IgG subclass specific. This situation applies both to …

Integrative epigenome-wide analysis demonstrates that DNA methylation may mediate genetic risk in inflammatory bowel disease Open

Nicholas T. Ventham, Nicholas A. Kennedy, Alex Adams, Rahul Kalla, Simon Heath , et al. · 2016

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