Jason A. Collett
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View article: IL-17A Levels and Progression of Kidney Disease Following Hospitalization with and without Acute Kidney Injury
IL-17A Levels and Progression of Kidney Disease Following Hospitalization with and without Acute Kidney Injury Open
Key Points IL-17A was higher in patients with AKI versus without AKI during hospitalization and up to 1-year postdischarge. IL-17A was higher in patients with progression of kidney disease but not independently associated with subsequent p…
View article: Subcutaneous injection of adipose stromal cell-secretome improves renal function and reduces inflammation in established acute kidney injury
Subcutaneous injection of adipose stromal cell-secretome improves renal function and reduces inflammation in established acute kidney injury Open
View article: Impaired hemodynamic renal reserve response following recovery from established acute kidney injury and improvement by hydrodynamic isotonic fluid delivery
Impaired hemodynamic renal reserve response following recovery from established acute kidney injury and improvement by hydrodynamic isotonic fluid delivery Open
Despite the apparent recovery of renal filtration function following acute kidney injury (AKI) in rats, the renal hemodynamic reserve response is significantly attenuated, suggesting that clinical evaluation of this parameter may provide i…
View article: Serum IL-17 levels are higher in critically ill patients with AKI and associated with worse outcomes
Serum IL-17 levels are higher in critically ill patients with AKI and associated with worse outcomes Open
View article: Orai1: A New Therapeutic Target for the Acute Kidney Injury-to-Chronic Kidney Disease Transition
Orai1: A New Therapeutic Target for the Acute Kidney Injury-to-Chronic Kidney Disease Transition Open
This review focuses on the potential mediation in the acute kidney injury (AKI)-to-chronic kidney disease (CKD) transition by lymphocytes. We highlight evidence that lymphocytes, particularly Th17 cells, modulate the severity of both acute…
View article: The anti‐dipsogenic and anti‐natriorexigenic effects of estradiol, but not the anti‐pressor effect, are lost in aged female rats
The anti‐dipsogenic and anti‐natriorexigenic effects of estradiol, but not the anti‐pressor effect, are lost in aged female rats Open
Estradiol (E2) inhibits fluid intake in several species, which may help to defend fluid homeostasis by preventing excessive extracellular fluid volume. Although this phenomenon is well established using the rat model, it has only been stud…
View article: In-vitro Stimulation of CD4+ Lymphocytes Following Renal Ischemia/Reperfusion Injury
In-vitro Stimulation of CD4+ Lymphocytes Following Renal Ischemia/Reperfusion Injury Open
To explore the Th-17 activation mechanism, renal CD4+ cells were isolated from post ischemic rats and stimulated in-vitro with varying conditions. These conditions focused on the effect of adenosine on IL-17 response using RT-PCR. Addition…
View article: Mutation of RORγT reveals a role for Th17 cells in both injury and recovery from renal ischemia-reperfusion injury
Mutation of RORγT reveals a role for Th17 cells in both injury and recovery from renal ischemia-reperfusion injury Open
To investigate T helper type 17 (Th17) cells in the setting of acute kidney injury, the gene encoding the master regulator of Th17 cell differentiation, that is, RAR-related orphan receptor-γ (RORγT), was mutated in Lewis rats using CRISPR…
View article: Exogenous Gene Transmission of Isocitrate Dehydrogenase 2 Mimics Ischemic Preconditioning Protection
Exogenous Gene Transmission of Isocitrate Dehydrogenase 2 Mimics Ischemic Preconditioning Protection Open
Ischemic preconditioning confers organ-wide protection against subsequent ischemic stress. A substantial body of evidence underscores the importance of mitochondria adaptation as a critical component of cell protection from ischemia. To id…
View article: Th17 cells contribute to pulmonary fibrosis and inflammation during chronic kidney disease progression after acute ischemia
Th17 cells contribute to pulmonary fibrosis and inflammation during chronic kidney disease progression after acute ischemia Open
Acute kidney injury (AKI) is associated with high mortality rates and predisposes development of chronic kidney disease (CKD). Distant organ damage, particularly in the lung, may contribute to mortality in AKI patients. Animal models of AK…
View article: Human adipose stromal cell therapy improves survival and reduces renal inflammation and capillary rarefaction in acute kidney injury
Human adipose stromal cell therapy improves survival and reduces renal inflammation and capillary rarefaction in acute kidney injury Open
Damage to endothelial cells contributes to acute kidney injury (AKI) by causing impaired perfusion, while the permanent loss of the capillary network following AKI has been suggested to promote chronic kidney disease. Therefore, strategies…
View article: Endothelial colony-forming cells ameliorate endothelial dysfunction via secreted factors following ischemia-reperfusion injury
Endothelial colony-forming cells ameliorate endothelial dysfunction via secreted factors following ischemia-reperfusion injury Open
Damage to endothelial cells contributes to acute kidney injury (AKI) by leading to impaired perfusion. Endothelial colony-forming cells (ECFC) are endothelial precursor cells with high proliferative capacity, pro-angiogenic activity, and i…
View article: Hydrodynamic Isotonic Fluid Delivery Ameliorates Moderate-to-Severe Ischemia-Reperfusion Injury in Rat Kidneys
Hydrodynamic Isotonic Fluid Delivery Ameliorates Moderate-to-Severe Ischemia-Reperfusion Injury in Rat Kidneys Open
Highly aerobic organs like the kidney are innately susceptible to ischemia-reperfusion (I/R) injury, which can originate from sources including myocardial infarction, renal trauma, and transplant. Therapy is mainly supportive and depends o…
View article: IL-17 mediates neutrophil infiltration and renal fibrosis following recovery from ischemia reperfusion: compensatory role of natural killer cells in athymic rats
IL-17 mediates neutrophil infiltration and renal fibrosis following recovery from ischemia reperfusion: compensatory role of natural killer cells in athymic rats Open
T cells have been implicated in the pathogenesis of acute kidney injury (AKI) and its progression to chronic kidney disease (CKD). Previous studies suggest that Th17 cells participate during the AKI-to-CKD transition, and inhibition of T c…
View article: Quantitative Real-Time PCR mt-genes across 4 complexes of ETC.
Quantitative Real-Time PCR mt-genes across 4 complexes of ETC. Open
A:mt-ND1 was reduced ~3.7 fold in HT BN/SHR-mtSHR (*P<0.05). mt-ND3 was reduced ~2.6 fold in HT SHR/BN-mtSHR (**P<0.01). mt-ND4 was reduced ~10.8 fold in HT SHR/BN-mtSHR (*P<0.05…
View article: Open problem-based instruction impacts understanding of physiological concepts differently in undergraduate students
Open problem-based instruction impacts understanding of physiological concepts differently in undergraduate students Open
Student populations are diverse such that different types of learners struggle with traditional didactic instruction. Problem-based learning has existed for several decades, but there is still controversy regarding the optimal mode of inst…
View article: Kidney-Specific Reduction of Oxidative Phosphorylation Genes Derived from Spontaneously Hypertensive Rat
Kidney-Specific Reduction of Oxidative Phosphorylation Genes Derived from Spontaneously Hypertensive Rat Open
Mitochondrial (Mt) dysfunction contributes to the pathophysiology of renal function and promotes cardiovascular disease such as hypertension. We hypothesize that renal Mt-genes derived from female spontaneously hypertensive rats (SHR) that…
View article: Th-17 cell activation in response to high salt following acute kidney injury is associated with progressive fibrosis and attenuated by AT-1R antagonism
Th-17 cell activation in response to high salt following acute kidney injury is associated with progressive fibrosis and attenuated by AT-1R antagonism Open