Jason A. Mears
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View article: Tracing the Cancer Research Training Footprint: A Longitudinal Bibliometric Evaluation of Two NCI T32 Cancer Training Programs
Tracing the Cancer Research Training Footprint: A Longitudinal Bibliometric Evaluation of Two NCI T32 Cancer Training Programs Open
A well-trained workforce is essential to advance cancer research and improve patient outcomes. The National Cancer Institute T32 Institutional Research Training Grant programs are designed to cultivate the next generation of cancer researc…
View article: The <i>Legionella</i> effector RidL promotes mitochondrial fragmentation through phosphorylation activation of the large GTPase Drp1
The <i>Legionella</i> effector RidL promotes mitochondrial fragmentation through phosphorylation activation of the large GTPase Drp1 Open
Intracellular pathogens such as Legionella pneumophila secrete effector proteins that manipulate host cell processes to promote bacterial survival. One such effector, RidL, is known to inhibit retrograde trafficking by interacting with the…
View article: Conformational Rearrangement of Fission DSPs
Conformational Rearrangement of Fission DSPs Open
Dynamin superfamily proteins (DSPs) are large GTPases that play crucial roles in membrane remodeling processes, including vesicle uptake, mitochondrial fission, and opposing fusion events. Among them, dynamin and dynamin‐related protein 1 …
View article: The Structure of the Drp1 Lattice on Membrane
The Structure of the Drp1 Lattice on Membrane Open
Mitochondrial health relies on the membrane fission mediated by dynamin-related protein 1 (Drp1). Previous structural studies of Drp1 on remodeled membranes were hampered by heterogeneity, leaving a critical gap in the understanding of the…
View article: The Structure of the Drp1 Lattice on Membrane
The Structure of the Drp1 Lattice on Membrane Open
Mitochondrial health relies on the membrane fission mediated by dynamin-related protein 1 (Drp1). Previous structural studies of Drp1 on remodeled membranes were hampered by heterogeneity, leaving a critical gap in the understanding of the…
View article: Structural basis for regulated assembly of the mitochondrial fission GTPase Drp1
Structural basis for regulated assembly of the mitochondrial fission GTPase Drp1 Open
Mitochondrial fission is a critical cellular event to maintain organelle function. This multistep process is initiated by the enhanced recruitment and oligomerization of dynamin-related protein 1 (Drp1) at the surface of mitochondria. As s…
View article: Allosteric control of dynamin-related protein 1 through a disordered C-terminal Short Linear Motif
Allosteric control of dynamin-related protein 1 through a disordered C-terminal Short Linear Motif Open
View article: CNSC-15. MITOCHONDRIA TRANSFER VIA GLIOMA-ASTROCYTE NETWORK MICROTUBES REPROGRAMS TUMOR CELLS FOR ENHANCED TUMORIGENICITY
CNSC-15. MITOCHONDRIA TRANSFER VIA GLIOMA-ASTROCYTE NETWORK MICROTUBES REPROGRAMS TUMOR CELLS FOR ENHANCED TUMORIGENICITY Open
Glioblastoma (GBM) interaction with neural cells is critical to its pathobiology. Emerging evidence suggests that GBM cells form an interconnected network with astrocytes, facilitating tumor persistence. Given reports of intercellular tran…
View article: 230 Immunosuppression causes dynamic changes in expression QTLs in psoriatic skin
230 Immunosuppression causes dynamic changes in expression QTLs in psoriatic skin Open
View article: High-Resolution Structural Proteomics of Mitochondria Using the ‘Build and Retrieve’ Methodology
High-Resolution Structural Proteomics of Mitochondria Using the ‘Build and Retrieve’ Methodology Open
View article: Allosteric control of dynamin-related protein 1-catalyzed mitochondrial fission through a conserved disordered C-terminal Short Linear Motif
Allosteric control of dynamin-related protein 1-catalyzed mitochondrial fission through a conserved disordered C-terminal Short Linear Motif Open
The mechanochemical GTPase dynamin-related protein 1 (Drp1) catalyzes mitochondrial fission, but the regulatory mechanisms remain ambiguous. Here we found that a conserved, intrinsically disordered, six-residue S hort Li near M otif at the…
View article: Allosteric control of dynamin-related protein 1-catalyzed mitochondrial fission through a conserved disordered C-terminal Short Linear Motif
Allosteric control of dynamin-related protein 1-catalyzed mitochondrial fission through a conserved disordered C-terminal Short Linear Motif Open
The mechanochemical GTPase dynamin-related protein 1 (Drp1) catalyzes mitochondrial fission, but the regulatory mechanisms remain ambiguous. Here we found that a conserved, intrinsically disordered, six-residue S hort Li near M otif at the…
View article: Structural Basis for Regulated Assembly of the Mitochondrial Fission GTPase Drp1
Structural Basis for Regulated Assembly of the Mitochondrial Fission GTPase Drp1 Open
Mitochondrial fission is crucial for distributing cellular energy throughout cells and for isolating damaged regions of the organelle that are targeted for degradation. This multistep process is initiated by the enhanced recruitment and ol…
View article: GAP43-dependent mitochondria transfer from astrocytes enhances glioblastoma tumorigenicity
GAP43-dependent mitochondria transfer from astrocytes enhances glioblastoma tumorigenicity Open
View article: Disease-associated mutations in Drp1 have fundamentally different effects on the mitochondrial fission machinery
Disease-associated mutations in Drp1 have fundamentally different effects on the mitochondrial fission machinery Open
Patient mutations have been identified throughout dynamin-related protein 1 (Drp1), the key protein mediator of mitochondrial fission. These changes generally impact young children and often result in severe neurological defects and, in so…
View article: DRP1 mutations associated with EMPF1 encephalopathy alter mitochondrial membrane potential and metabolic programs
DRP1 mutations associated with EMPF1 encephalopathy alter mitochondrial membrane potential and metabolic programs Open
Mitochondria and peroxisomes are dynamic signaling organelles that constantly undergo fission, driven by the large GTPase dynamin-related protein 1 (DRP1; encoded by DNM1L). Patients with de novo heterozygous missense mutations in DNM1L pr…
View article: Adaptive exhaustion during prolonged intermittent hypoxia causes dysregulated skeletal muscle protein homeostasis
Adaptive exhaustion during prolonged intermittent hypoxia causes dysregulated skeletal muscle protein homeostasis Open
Nocturnal hypoxaemia, which is common in chronic obstructive pulmonary disease (COPD) patients, is associated with skeletal muscle loss or sarcopenia, which contributes to adverse clinical outcomes. In COPD, we have defined this as prolong…
View article: Drp1 and the cytoskeleton: mechanistic nexus in mitochondrial division
Drp1 and the cytoskeleton: mechanistic nexus in mitochondrial division Open
View article: Solvent accessibility of E1α and E1β residues with known missense mutations causing pyruvate dehydrogenase complex (<scp>PDC</scp>) deficiency: Impact on <scp>PDC‐E1</scp> structure and function
Solvent accessibility of E1α and E1β residues with known missense mutations causing pyruvate dehydrogenase complex (<span>PDC</span>) deficiency: Impact on <span>PDC‐E1</span> structure and function Open
Pyruvate dehydrogenase complex deficiency is a major cause of primary lactic acidemia resulting in high morbidity and mortality, with limited therapeutic options. PDHA1 mutations are responsible for >82% of cases. The E1 component of PDC i…
View article: DRP1-mediated mitochondrial fission is essential to maintain cristae morphology and bioenergetics
DRP1-mediated mitochondrial fission is essential to maintain cristae morphology and bioenergetics Open
Mitochondria and peroxisomes are both dynamic signaling organelles that constantly undergo fission. While mitochondrial fission is known to coordinate cellular metabolism, proliferation, and apoptosis, the physiological relevance of peroxi…
View article: Blocked O-GlcNAc cycling alters mitochondrial morphology, function, and mass
Blocked O-GlcNAc cycling alters mitochondrial morphology, function, and mass Open
View article: CSL112 (human apolipoprotein A-I) infusion rapidly increases apoA-I exchange rate (AER) when administered to patients post myocardial infarction
CSL112 (human apolipoprotein A-I) infusion rapidly increases apoA-I exchange rate (AER) when administered to patients post myocardial infarction Open
Background Cholesterol efflux capacity (CEC) measured using patient serum and cultured macrophages is considered a biomarker of high-density lipoprotein (HDL) functionality. This parameter is inversely related to incident cardiovascular ev…
View article: Astrocytes donate mitochondria to increase glioblastoma tumorigenicity
Astrocytes donate mitochondria to increase glioblastoma tumorigenicity Open
Glioblastoma (GBM), the most common primary brain cancer in adults1, is characterized by numerous cell-intrinsic/extrinsic interactions that drive tumorigenesis. In addition to cell-surface and secreted protein/extracellular vesicle intera…
View article: Horizontal mitochondrial transfer from the microenvironment increases glioblastoma tumorigenicity
Horizontal mitochondrial transfer from the microenvironment increases glioblastoma tumorigenicity Open
While dynamic microenvironmental interactions drive tumor growth and therapeutic resistance, the underlying direct cell-cell communication mechanisms remain poorly understood. We identified horizontal mitochondrial transfer as a mechanism …
View article: A structure and function relationship study to identify the impact of the R721G mutation in the human mitochondrial lon protease
A structure and function relationship study to identify the impact of the R721G mutation in the human mitochondrial lon protease Open
View article: Decision letter: Protective mitochondrial fission induced by stress-responsive protein GJA1-20k
Decision letter: Protective mitochondrial fission induced by stress-responsive protein GJA1-20k Open
Article Figures and data Abstract Introduction Results Discussion Materials and methods Appendix 1 Data availability References Decision letter Author response Article and author information Metrics Abstract The Connexin43 gap junction gen…
View article: GFP fluorescence tagging alters dynamin-related protein 1 oligomerization dynamics and creates disassembly-refractory puncta to mediate mitochondrial fission
GFP fluorescence tagging alters dynamin-related protein 1 oligomerization dynamics and creates disassembly-refractory puncta to mediate mitochondrial fission Open
View article: Investigating Interactions in the Drp1-Mff Copolymer that Contributes to Mitochondrial Fission
Investigating Interactions in the Drp1-Mff Copolymer that Contributes to Mitochondrial Fission Open
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View article: Conformational Changes in Solution Multimers of Dynamin-related Protein 1 (Drp1) Facilitate Functional Assembly
Conformational Changes in Solution Multimers of Dynamin-related Protein 1 (Drp1) Facilitate Functional Assembly Open
An abstract is not available for this content so a preview has been provided. As you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
View article: Affinity Purification and Functional Characterization of Dynamin-Related Protein 1
Affinity Purification and Functional Characterization of Dynamin-Related Protein 1 Open