Jason C. Bell
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View article: BRCA2 chaperones RAD51 to single molecules of RPA-coated ssDNA
BRCA2 chaperones RAD51 to single molecules of RPA-coated ssDNA Open
Mutations in the breast cancer susceptibility gene, BRCA2 , greatly increase an individual’s lifetime risk of developing breast and ovarian cancers. BRCA2 suppresses tumor formation by potentiating DNA repair via homologous recombination. …
View article: Assembly mechanism and cryoEM structure of RecA recombination nucleofilaments from<i>Streptococcus pneumoniae</i>
Assembly mechanism and cryoEM structure of RecA recombination nucleofilaments from<i>Streptococcus pneumoniae</i> Open
RecA-mediated homologous recombination (HR) is a key mechanism for genome maintenance and plasticity in bacteria. It proceeds through RecA assembly into a dynamic filament on ssDNA, the presynaptic filament, which mediates DNA homology sea…
View article: BRCA2 chaperones RAD51 to single molecules of RPA-coated ssDNA
BRCA2 chaperones RAD51 to single molecules of RPA-coated ssDNA Open
Mutations in the breast cancer susceptibility gene, BRCA2, greatly increase an individual’s lifetime risk of developing breast and ovarian cancers. BRCA2 suppresses tumor formation by potentiating DNA repair via homologous recombination. C…
View article: Massively parallel single-cell chromatin landscapes of human immune cell development and intratumoral T cell exhaustion
Massively parallel single-cell chromatin landscapes of human immune cell development and intratumoral T cell exhaustion Open
Understanding complex tissues requires single-cell deconstruction of gene regulation with precision and scale. Here we present a massively parallel droplet-based platform for mapping transposase-accessible chromatin in tens of thousands of…
View article: Chromatin‐Associated RNA Sequencing (ChAR‐seq)
Chromatin‐Associated RNA Sequencing (ChAR‐seq) Open
RNA is a fundamental component of chromatin. Noncoding RNAs (ncRNAs) can associate with chromatin to influence gene expression and chromatin state; many also act at long distances from their transcriptional origin. Yet we know almost nothi…
View article: Chromatin-associated RNA sequencing (ChAR-seq) maps genome-wide RNA-to-DNA contacts
Chromatin-associated RNA sequencing (ChAR-seq) maps genome-wide RNA-to-DNA contacts Open
RNA is a critical component of chromatin in eukaryotes, both as a product of transcription, and as an essential constituent of ribonucleoprotein complexes that regulate both local and global chromatin states. Here, we present a proximity l…
View article: RNA-dependent stabilization of SUV39H1 at constitutive heterochromatin
RNA-dependent stabilization of SUV39H1 at constitutive heterochromatin Open
Heterochromatin formed by the SUV39 histone methyltransferases represses transcription from repetitive DNA sequences and ensures genomic stability. How SUV39 enzymes localize to their target genomic loci remains unclear. Here, we demonstra…
View article: Author response: RNA-dependent stabilization of SUV39H1 at constitutive heterochromatin
Author response: RNA-dependent stabilization of SUV39H1 at constitutive heterochromatin Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Heterochromatin formed by the…
View article: Intramolecular dynamics of single molecules in free diffusion
Intramolecular dynamics of single molecules in free diffusion Open
Biomolecular systems such as multiprotein complexes or biopolymers can span several tens to several hundreds of nanometers, but the dynamics of such “mesocale” molecules remain challenging to probe. We have developed a single-molecule tech…
View article: Chromatin-associated RNA sequencing (ChAR-seq) maps genome-wide RNA-to-DNA contacts
Chromatin-associated RNA sequencing (ChAR-seq) maps genome-wide RNA-to-DNA contacts Open
RNA is a critical component of chromatin in eukaryotes, both as a product of transcription, and as an essential constituent of ribonucleoprotein complexes that regulate both local and global chromatin states. Here we present a proximity li…
View article: Mechanics and Single-Molecule Interrogation of DNA Recombination
Mechanics and Single-Molecule Interrogation of DNA Recombination Open
The repair of DNA by homologous recombination is an essential, efficient, and high-fidelity process that mends DNA lesions formed during cellular metabolism; these lesions include double-stranded DNA breaks, daughter-strand gaps, and DNA c…